2013
DOI: 10.1021/ac402382d
|View full text |Cite
|
Sign up to set email alerts
|

Online NMR and HPLC as a Reaction Monitoring Platform for Pharmaceutical Process Development

Abstract: Detector response is not always equivalent between detectors or instrument types. Factors that impact detector response include molecular structure and detection wavelength. In liquid chromatography (LC), ultraviolet (UV) is often the primary detector; however, without determination of UV response factors for each analyte, chromatographic results are reported on an area percent rather than a weight percent. In extreme cases, response factors can differ by several orders of magnitude for structurally dissimilar… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
67
0

Year Published

2014
2014
2024
2024

Publication Types

Select...
6
3

Relationship

1
8

Authors

Journals

citations
Cited by 86 publications
(67 citation statements)
references
References 18 publications
0
67
0
Order By: Relevance
“…Three modes of NMR spectroscopy reaction monitoring were investigated; online NMR spectroscopy, NMR tube reaction monitoring with and without periodic agitation of the reaction mixture. The online NMR method, using our custom reaction monitoring system, was directly compared with the basic method of reaction monitoring in an NMR tube . A third method was also used involving periodic inversion by inverting a standard NMR tube three times during the interval between each NMR spectrum acquisition.…”
Section: Resultsmentioning
confidence: 99%
“…Three modes of NMR spectroscopy reaction monitoring were investigated; online NMR spectroscopy, NMR tube reaction monitoring with and without periodic agitation of the reaction mixture. The online NMR method, using our custom reaction monitoring system, was directly compared with the basic method of reaction monitoring in an NMR tube . A third method was also used involving periodic inversion by inverting a standard NMR tube three times during the interval between each NMR spectrum acquisition.…”
Section: Resultsmentioning
confidence: 99%
“…Such portable systems would enable the application of NMR spectroscopy to situations where large, expensive conventional NMR spectrometers cannot be installed, yet online or on-demand analysis is ideal or necessary. For example, portable systems can be used in an industrial production line to inspect the product quality (34) may also facilitate, and lower the cost of, multimodal analysis where NMR spectroscopy is combined with and complemented by other analytical methods such as liquid chromatography (12), capillary electrophoresis (13), mass spectrometry, and Fourier transform infrared spectroscopy. The NMR sensitivity of these miniaturized systems can be further enhanced by techniques such as parahydrogen polarization transfer (36).…”
Section: Discussionmentioning
confidence: 99%
“…In this case, portable, affordable, and low-maintenance NMR spectrometers built with a permanent magnet can make the benefits of NMR spectroscopy more broadly available and enable new applications. Bulky superconducting systems have to be permanently placed in dedicated laboratories, but portable systems can enable in-field, on-demand, or online applications such as quality control and chemical reaction monitoring (4), and can greatly facilitate co-use of NMR spectroscopy with other analytical methods such as liquid chromatography (12) and capillary electrophoresis (13). Thus, much effort has been devoted to miniaturizing NMR spectrometers, leading to the critical development of small permanent magnets with high field homogeneity (10,14,15).…”
mentioning
confidence: 99%
“…Among various analytical techniques, mass spectrometry is most commonly used to complement HPLC. Other useful techniques include ion mobility spectrometry, nuclear magnetic resonance spectroscopy, and surface plasmon resonance 110,111 .…”
Section: Ease Of Coupling To Other Techniquesmentioning
confidence: 99%