The pandemic has had a multifaceted impact on individuals of all age groups, giving rise to a myriad of psychological challenges and problems. This effect has been particularly pronounced among university students who harbor concerns about their education and future prospects. In these trying times of COVID-19, it is of paramount importance to discern the factors that bolster or impede the mental health and overall well-being of college students. This knowledge serves as the foundation for delivering preventive and interventional support services. The objective of this study was to identify the biopsychosocial, spiritual, and economic factors that either enhance or hinder the lives of students specializing in Islamic sciences during the COVID-19 pandemic. To achieve this, the Online Photovoice (OPV) method was employed. The study engaged 108 participants (68 female and 40 male) from an Islamic Studies Department in Turkey. The findings revealed 27 factors that facilitated well-being, including elements such as the beauty of nature, positive emotions, and the support of family and relatives. Conversely, 27 factors were identified as non-facilitating, including issues like inadequate planning and communication, confinement indoors, and the experience of negative emotions. Professionals working with college students can leverage these insights to better serve their needs and address the challenges they face. In conclusion, understanding the diverse factors that impact the lives of university students during the pandemic, both positively and negatively, is essential for guiding effective support and intervention strategies. By recognizing these facets, this study provides important implications for promoting the mental health and well-being of students, ensuring a brighter and more resilient future in the face of unprecedented challenges.