“…Indeed, recent studies have documented a staggering increase in a variety of risk factors for substance use and overdose, including worsening psychiatric outcomes (e.g., stress, anxiety, depression), loneliness, economic distress, and disruptions to daily living and routine PLOS ONE (e.g., childcare burden, poor sleep quality) [35][36][37][38][39], increased likelihood of using drugs alone, changes to illicit drug supplies [23], and reduced physical access to treatment services. On the other hand, mitigating influences could have included the relaxation of restrictions on dispensation of methadone and buprenorphine, disruption to supply chains for illicit drugs, and adherence to stay-at-home mandates and physical-distancing guidelines, which might reduce drug-acquisition behaviors [40][41][42][43][44][45].…”