Online specific recognition of mycotoxins using aptamer-grafted ionic affinity monolith with mixed-mode mechanism

Chi, Jinxin; Zhu, Dandan; Chen, Yiqiong; Huang, Guihua; Lin, Xucong

doi:10.1016/j.chroma.2021.461930

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Especially nowadays, university microcourses, mooc, spoc, flipped classrooms, deep learning and so on have become popular. Independent learning, personalized learning and lifelong learning are more and more important, and blended teaching has become the most suitable teaching mode in the era of "Internet +" [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Exploration and Practice of Online-Offline Hybrid Teaching Mode in Teaching Higher Education Courses under the Background of Internet+

Wang

2023

Applied Mathematics and Nonlinear Sciences

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In this paper, a Bayesian approach and a recommendation algorithm are used to construct a method for evaluating students’ competence in a hybrid teaching model. The Bayesian method is used to create a mathematical description of the student’s ability level. The purpose of classification is achieved by extracting features of students’ learning results and preference directions using the simple Bayesian method. According to the recommendation algorithm, the recommended objects’ content features are retrieved, and teaching resources with high matching degrees are recommended for students. The recommendation algorithm in this paper can effectively determine the ability level of students, as demonstrated by the results. The probability of the highest P1 mastery rate among A-E students is 0.3179 for B students, and the probability of the highest P2 mastery rate is 0.1409 for D students. The average score of the experimental class that implements blended teaching is 76.631, while the average score of the control class is 73.7841, and the experimental class is 2.8469 points higher than the control class. 2.8469 points. This study promotes the development and progress of blended teaching to a certain extent.

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Section: Introductionmentioning

confidence: 99%

Exploration and Practice of Online-Offline Hybrid Teaching Mode in Teaching Higher Education Courses under the Background of Internet+

Wang

2023

Applied Mathematics and Nonlinear Sciences

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“…Monolith is a 3D porous structured material with micrometer- to nanometer-sized continuous interconnected fluidic channel networks. − As the traditional stationary phase in liquid chromatography, monolith not only has a unique characteristic of supporting the rapid permeation of the aqueous phase while offering short characteristic diffusion lengths, but also provides a high specific surface area and active sites for enhancing analyte–monolith interactions . Monolith has the potential advantage that the unique porous network provides a high surface area, resulting in much more active sites participating in Raman scattering.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticle-Decorated Porous Silica for Surface-Enhanced Raman Scattering-Based Detection of Trace Molecules in Liquid Phase

Chi

Xia

Guo

et al. 2022

ACS Appl. Nano Mater.

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Development of a facile and cost-effective surface-enhanced Raman scattering (SERS) sensor with high sensitivity for the on-site rapid detection of trace molecules is a compelling need. Here we report how a capillary-based three-dimensional network porous silica material decorated with gold nanoparticles (3D-PSM@AuNPs) serves as an ideal platform for the rapid static liquidphase detection of trace molecules. The SERS sensor is prepared by an in situ polymerization method to form a 3D continuous interconnected porous network in an ultraviolet transparent quartz capillary with a facile fabrication process. The unique porous network of the silica, which could provide a high specific surface area in a focus volume, endows the resultant material with a high density of SERS enhancement sites and a "hot-spot", which has precisely guaranteed the detection sensitivity. More importantly, the unique structure of the capillary could also present an aid to reduce the energy loss of the laser via multiple reflections and thus effectively improve the utilization rate of the laser beam. Using 4-mercaptopyridine (4-MPY) in aqueous solution as a model molecule, the porous silica material exhibits a high detection sensitivity (10 −11 M), excellent stability, and repeatability. Moreover, the obtained 3D-PSM@AuNP sensor is applied for the analysis of phosmet residues on orange peel and vegetables. The results demonstrate that this 3D-PSM@AuNP sensor can successfully realize Raman reporter-free and rapid on-site detection of trace molecules in liquids, which provides a promising platform in various fields of micro-volume liquid sample analysis, especially in liquid biopsy analysis.

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In situ photo-initiated polymerized oligonucleotide-functionalized hydrophilic capillary affinity monolith for highly selective in-tube microextraction of ochratoxin A mycotoxin

et al. 2021

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Online specific recognition of mycotoxins using aptamer-grafted ionic affinity monolith with mixed-mode mechanism

Cited by 6 publications

References 35 publications

Exploration and Practice of Online-Offline Hybrid Teaching Mode in Teaching Higher Education Courses under the Background of Internet+

Exploration and Practice of Online-Offline Hybrid Teaching Mode in Teaching Higher Education Courses under the Background of Internet+

Gold Nanoparticle-Decorated Porous Silica for Surface-Enhanced Raman Scattering-Based Detection of Trace Molecules in Liquid Phase

In situ photo-initiated polymerized oligonucleotide-functionalized hydrophilic capillary affinity monolith for highly selective in-tube microextraction of ochratoxin A mycotoxin

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