This pilot study focuses on employment of hybrid LMS-ICA system for in-vehicle background noise reduction. Modern vehicles are nowadays increasingly supporting voice commands, which are one of the pillars of autonomous and SMART vehicles. Robust speaker recognition for contextaware in-vehicle applications is limited to a certain extent by in-vehicle background noise. This article presents the new concept of a hybrid system, which is implemented as a virtual instrument. The highly modular concept of the virtual car used in combination with real recordings of various driving scenarios enables effective testing of the investigated methods of in-vehicle background noise reduction. The study also presents a unique concept of an adaptive system using intelligent clusters of distributed next generation 5G data networks, which allows the exchange of interference information and/or optimal hybrid algorithm settings between individual vehicles. On average, the unfiltered voice commands were successfully recognized in 29.34% of all scenarios, while the LMS reached up to 71.81%, and LMS-ICA hybrid improved the performance further to 73.03%.