Online versus paper-based screening for depression and anxiety in adults with cystic fibrosis in Ireland: a cross-sectional exploratory study

Cronly, Jennifer; Duff, Alistair; Riekert, Kristin A.; Perry, Ivan J.; Fitzgerald, Anthony P.; Horgan, Áine; Lehane, Elaine; Howe, Barbara; Chróinín, Muireann Ní; Savage, Eileen

doi:10.1136/bmjopen-2017-019305

Cited by 30 publications

(25 citation statements)

References 37 publications

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“…35 Although data from nonresponders were not available for comparison, data analysis conducted on the online and clinic samples yielded comparable findings. 21 Second, the physical health predictors used, FEV 1 % and BMI, were self-reported, and cross-checking with medical notes was not feasible due to resource constraints. In addition, these predictors may not have fully captured physical health status for all the participants because previous studies have indicated recent pulmonary exacerbations may also predict HRQOL in people with cystic fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Challenges associated with access and data collection in clinics resulted in slow recruitment, and, consequently, the decision was made to also recruit online. 21 An e-mail link to the questionnaire was sent by the charity Cystic Fibrosis Ireland to its community network of 345 adults with cystic fibrosis. The online version of the questionnaire was developed and administered by using the cloud-based software SurveyMonkey (at SurveyMonkey.com, San Mateo, California).…”

Section: Methodsmentioning

confidence: 99%

“…However, due to challenges in recruitment, this sample size could not be attained. 21 The sample size of 141 adults and 33 adolescents (14 -18 y old) included in the HRQOL analysis represented 23.7% of the adult and 9.6% of the adolescent cystic fibrosis population in Ireland, respectively.…”

Section: Participantsmentioning

confidence: 99%

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Health-Related Quality of Life in Adolescents and Adults With Cystic Fibrosis: Physical and Mental Health Predictors

Cronly

Duff

Riekert³

et al. 2018

Respir Care

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BACKGROUND: People with cystic fibrosis face substantial physical, psychological, and social challenges as they move into adolescence and adulthood, which are likely to impact on their health-related quality of life. This study sought to examine the relative importance of physical and mental health variables associated with health-related quality of life in this group. METHODS: Adults and adolescents (N ‫؍‬ 174; >14 y old) from across 11 adult or pediatric cystic fibrosis clinics in the Republic of Ireland, completed a background questionnaire that contained self-reported physical health variables, pulmonary function (ie, FEV 1 %) and body mass index. Questionnaire packs also contained the Hospital Anxiety and Depression Scale (HADS) and the Cystic Fibrosis Questionnaire-Revised, which has been specifically designed to assess health-related quality of life in patients with cystic fibrosis. RESULTS: HADS depression and/or anxiety scores were negatively associated with 11 of the 12 Cystic Fibrosis Questionnaire-Revised domain scores. FEV 1 % was positively associated with 8 domains when controlling for HADS anxiety but only 4 domains when controlling for HADS depression. HADS anxiety and depression scores demonstrated larger effect sizes and explained a greater proportion of the variance than pulmonary function in 8 of the 12 Cystic Fibrosis Questionnaire-Revised domain scores. CONCLUSIONS: Mental health variables, depression and anxiety, were strongly associated with health-related quality of life in subjects with cystic fibrosis and demonstrated greater effect sizes and explained a higher proportion of the variance overall than the physical health indicators, FEV 1 % and body mass index, which highlighted the importance of screening for, and treating, depression and anxiety symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Health-Related Quality of Life in Adolescents and Adults With Cystic Fibrosis: Physical and Mental Health Predictors

Cronly

Duff

Riekert³

et al. 2018

Respir Care

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“…The strengths of this study include being the first study we are aware of to explore general community views on DURC, and the use of a before-and-after design to measure baseline views and changes following provision of information. The use of an established online community surveying methodology with a representative community sample is also a strength, as it is more convenient for participants and provides similar representativeness and results to paper-based surveys 48. The limitations of this study include the potential of bias in the framing of the survey, but we aimed to minimise this in our design.…”

Section: Discussionmentioning

confidence: 99%

Public awareness, acceptability and risk perception about infectious diseases dual-use research of concern: a cross-sectional survey

et al. 2020

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ObjectivesIn this study, we aimed to measure the awareness, acceptability and perceptions of current issues in biosecurity posed by infectious diseases dual-use research of concern (DURC) in the community. DURC is conducted today in many locations around the world for the benefit of humanity but may also cause harm through either a laboratory accident or deliberate misuse. Most DURC is approved by animal ethics committees, which do not typically consider harm to humans. Given the unique characteristics of contagion and the potential for epidemics and pandemics, the community is an important stakeholder in DURC.DesignSelf-administered web-based cross-sectional survey.ParticipantsParticipants over the age of 18 in Australia and 21 in the USA were included in the survey. A total of 604 participants completed the study. The results of 52 participants were excluded due to potential biases about DURC stemming from their employment as medical researchers, infectious diseases researchers or law enforcement professionals, leaving 552 participants. Of those, 274 respondents resided in Australia and 278 in the USA.OutcomesBaseline awareness, acceptability and perceptions of current issues surrounding DURC. Changes in perception from baseline were measured after provision of information about DURC.ResultsPresurvey, 77% of respondents were unaware of DURC and 64% found it unacceptable or were unsure. Two-thirds of respondents did not change their views. The baseline perception of high risk for laboratory accidents (29%) and deliberate bioterrorism (34%) was low but increased with increasing provision of information (42% and 44% respectively, p<0.001), with men more accepting of DURC (OR=1.79, 95% CI 1.25 to 2.57, p=0.002). Postsurvey, higher education predicted lower risk perception of laboratory accidents (OR=0.56, 95% CI 0.34 to 0.93, p=0.02) and bioterrorism (OR=0.48, 95% CI 0.29 to 0.80, p=0.004).ConclusionThe community is an important stakeholder in infectious diseases DURC but has a low awareness of this kind of research. Only a minority support DURC, and this proportion decreased with increasing provision of knowledge. There were differences of opinion between age groups, gender and education levels. The community should be informed and engaged in decisions about DURC.

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“…There are some publications about the possibilities of using online-HADS-D for assessing depressive symptoms, but only in specific cohorts: in patients with cystic fibrosis [12] and in patients with tinnitus [13]. The potential of the online version of HADS as a screening tool for the detection and phenotyping of depression in the general population has not yet been explored.…”

mentioning

confidence: 99%

Evaluation of applicability of the online version of HADS-D for depression phenotype screening in the general population

Kibitov

Rakitko

Kasyanov

et al. 2020

Preprint

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One of the most promising areas of research into the biological underpinnings of depression is genetic studies. However, the absence of generally accepted phenotyping methods leads to the difficulties in generalizing their results due to the heterogeneity of the samples. Thus, the development of a reliable and convenient phenotyping method that allows large sample sizes to be included in studies remains a top priority for the further development of genetic studies of depression. The aim of this study was to evaluate the applicability of the online version of the depression subscale of Hospital Anxiety and Depression Scale (HADS-D) for depression phenotype screening in the general population. Using online HADS-D we performed screening of depressive symptoms and compared results with known population patterns of depression. We conducted an online survey of 2610 Russian-speaking respondents over the age of 18. The overall HADS-D score was higher in women (p=0.003), in individuals under 30 y.o compared to participants over 42 y.o.(p=0.004) and in individuals reporting cardiovascular diseases (CVD) symptoms (p<0.0001). Linear regression showed that the presence of CVD leads to higher HADS-D scores (p<0.001), male gender (p=0.002) and older age (p<0.001) led to lower scores. Logistic regression showed that CVD increases the risk of having depression symptoms by HADS-D (p=0.033, OR=1.29), older age (p=0.015, OR=0.87) and male sex (as a trend, p=0.052, OR=0.80) decrease this risk. These results are consistent with the known data on the association of sex, age, and the presence of CVD with the prevalence of depression. The online version of HADS-D, given the ease of its usage, can be regarded as an effective tool for phenotyping depression in the general population.

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Online versus paper-based screening for depression and anxiety in adults with cystic fibrosis in Ireland: a cross-sectional exploratory study

Cited by 30 publications

References 37 publications

Health-Related Quality of Life in Adolescents and Adults With Cystic Fibrosis: Physical and Mental Health Predictors

Health-Related Quality of Life in Adolescents and Adults With Cystic Fibrosis: Physical and Mental Health Predictors

Public awareness, acceptability and risk perception about infectious diseases dual-use research of concern: a cross-sectional survey

Evaluation of applicability of the online version of HADS-D for depression phenotype screening in the general population

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