Network virtualization is considered as a key technology for the future network. The emergence of software-defined network (SDN) provides a platform for the research and development of network virtualization. One of the key challenges in network virtualization is virtual network embedding (VNE). Some of the previous VNE algorithms perform virtual node embedding, which combines the nodes’ resource attributes and local topology attributes by arithmetic operations. On the one hand, it is not easy to distinguish the topological differences between SN and VN only by simple topology metrics. On the other hand, it is easy to ignore the different weight impacts of different metrics using only arithmetic operations, which will lead to an unbalanced embedding solution. To deal with these issues, we propose a novel node-ranking approach based on topology-differentiating (VNE-NRTD) for SDN-based virtual network embedding. Owing to the topological difference between SN and VN, different node metrics are used to quantify the substrate nodes and virtual nodes, respectively. Then, the nodes are ranked using the modified set pair analysis (SPA) method to avoid the unbalanced embedding solution. On this basis, we introduce the global bandwidth of the network topology into node-ranking to further improve the efficiency of node embedding. The simulation results show that the VNE-NRTD algorithm proposed in this paper outperforms other latest heuristic algorithms in terms of the VNR acceptance ratio, long-term average R/C ratio, substrate node utilization, and substrate link utilization.