Only physical aspects of quality of life are significantly improved by bilateral subthalamic stimulation in Parkinson’s disease

Drapier, Sophie; Raoul, Sylvie; Drapier, Dominique; Leray, Emmanuelle; Lallement, François; Rivier, I.; Sauleau, Paul; Lajat, Youen; Edan, Gilles; Vérin, Marc

doi:10.1007/s00415-005-0704-4

Cited by 85 publications

(74 citation statements)

References 30 publications

(36 reference statements)

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“…Quality of life improves after STN DBS, 56,[63][64][65][66][67] and this improvement correlates with motor benefit. 65 In support of this finding, the physical markers for quality of life are reported to improve significantly, but other aspects such as mental, emotional well-being, social support, cognition, and communication show no improvement.…”

Section: Beneficial Effectmentioning

confidence: 93%

“…65 In support of this finding, the physical markers for quality of life are reported to improve significantly, but other aspects such as mental, emotional well-being, social support, cognition, and communication show no improvement. 66,67 The improvement in quality of life is maintained over time. 64,65 The caregiver's quality of life can also improve.…”

Section: Beneficial Effectmentioning

confidence: 99%

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Deep Brain Stimulation for Parkinson’s Disease

2008

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Summary:The surgical treatment of Parkinson's disease has been through a revival phase over the last 20 years with the development of deep brain stimulation (DBS). Thalamic DBS was developed first and has proven to be a very effective treatment for tremor. The limitation is the lack of effect on other symptoms. Other targets were therefore investigated, and the procedure was applied to the subthalamic nucleus (STN) and the internal globus pallidus (GPi). STN stimulation can improve a wide range of symptoms and is currently the preferred target for many patients. Nevertheless, the morbidity seems higher than with other targets, and the selection criteria have to be quite strict. When STN DBS is not advised, thalamic DBS remains an option for patients with severe tremor, and GPi stimulation for those with severe dyskinesias. DBS remains a symptomatic treatment for a limited number of patients; it does not seem to alter the disease progression, and many patients are not suitable. There is, therefore, the need for further research into other targets and other approaches.

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Section: Beneficial Effectmentioning

confidence: 93%

Section: Beneficial Effectmentioning

confidence: 99%

Deep Brain Stimulation for Parkinson’s Disease

2008

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“…STN stimulation could have a direct effect on affective disorders through its limbic connections. Our group has already demonstrated that some affective disorder can follow STN-DBS in PD, particularly in the emotional domain [5,10]. Current estimates of the prevalence of apathy in Parkinson's Disease vary between 16.5% [1] to 42% [41], depending upon the instrument used for assessment and the samples examined.…”

Section: Introductionmentioning

confidence: 99%

Does subthalamic nucleus stimulation induce apathy in Parkinson’s disease?

et al. 2006

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“…However, improvement in quality of life after bilateral STN stimulation can be related to only physical aspects. 42 Neuropsychological decline was not associated with improvement in motor scores. This implies that patients who did not show much improvement in motor functioning were not necessarily the ones who showed cognitive decline.…”

Section: Methodsmentioning

confidence: 90%

Solitary pyogenic abscess of the medulla oblongata: Survival after aspiration and antibiotics

Kniss¹,

Sivakumar²

2006

Neurology

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Abstract-Objective:To evaluate the cognitive and behavioral effects of bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease (PD). Methods: The authors included 103 patients; 99 patients were evaluated 6 months after surgery. A control group of 39 patients with PD was formed and 36 patients were evaluated 6 months later. At baseline and at follow-up we administered neuropsychological tests of language, memory, visuospatial function, mental speed, and executive functions. A depression rating scale, a quality of life scale, self and proxy ratings of memory and dysexecutive symptoms, and a neuropsychiatric interview were also administered. Results: Six months after surgery, the STN group showed a larger decline than the control group on measures of verbal fluency, color naming, selective attention, and verbal memory. Moreover, the STN group showed a decrease in positive affect, and an increase in emotional lability and cognitive complaints. On the other hand, the STN group showed an increase in quality of life and a slight decrease in depressive symptoms. Nine percent of the STN patients had psychiatric complications (vs 3% of controls). Conclusions: Bilateral subthalamic nucleus stimulation has an adverse effect on executive functions with implications for daily life of the patients and their relatives.

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Only physical aspects of quality of life are significantly improved by bilateral subthalamic stimulation in Parkinson’s disease

Cited by 85 publications

References 30 publications

Deep Brain Stimulation for Parkinson’s Disease

Deep Brain Stimulation for Parkinson’s Disease

Does subthalamic nucleus stimulation induce apathy in Parkinson’s disease?

Solitary pyogenic abscess of the medulla oblongata: Survival after aspiration and antibiotics

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