Onodera's Prognostic Nutritional Index as an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma

Broggi, Matthew S.; Patil, Dattatraya; Baum, Yoram; Nieh, Peter T.; Alemozaffar, Mehrdad; Pattaras, John; Ogan, Kenneth; Master, Viraj A.

doi:10.1016/j.urology.2016.05.064

Cited by 47 publications

(50 citation statements)

References 28 publications

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“…The O-PNI uses albumin and lymphocyte levels as nutrition-related factors, and was developed as a nutritional prognostic indicator [8], while it has also been used as a prognostic marker in cases with peritoneal dialysis [9], colectomy in ulcerative colitis [10], and renal cell carcinoma [11]. Onodera reported that resection and anastomosis of the gastrointestinal tract can be performed safely when the O-PNI is >45, while the same procedure may be dangerous when the value is between 45 and 40, and possibly contraindicated when ≤40 [8].…”

Section: Discussionmentioning

confidence: 99%

“…Onodera proposed Onodera's prognostic nutritional index (O-PNI), which is easily calculated with a formula that includes the serum albumin level and lymphocyte count, as a nutritional prognostic indicator in a report on 189 patients undergoing gastrointestinal surgery [8]. Thereafter, the O-PNI has been reported to be useful as a prognostic marker for patients undergoing peritoneal dialysis [9] or colectomy in ulcerative colitis [10], as well as for renal cell carcinoma patients [11].…”

Section: Introductionmentioning

confidence: 99%

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Nutritional Index as Prognostic Indicator in Patients Receiving Lenvatinib Treatment for Unresectable Hepatocellular Carcinoma

et al. 2020

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Background/Aim: Few studies have examined the details of nutritional status in patients with unresectable hepatocellular carcinoma (u-HCC) undergoing systemic chemotherapy with lenvatinib. We evaluated the prognostic/predictive value of nutritional status using Onodera's prognostic nutri-tional index (O-PNI) for overall survival among patients with u-HCC treated with lenvatinib. Methods: Three-hundred and seventy-five u-HCC patients treated with lenvatinib were enrolled (median age 72 years; Child-Pugh class A/B/C: n = 312/60/3; BCLC stage A/B/C/D: n = 2/159/212/2). We examined median survival time (MST) and time to progression (TTP) in all patients (n = 375), prognosis according to the O-PNI (high/low: >40/≤40) in 298 patients with lymphocyte findings, and the prognostic/predictive values of Child-Pugh stage, albumin-bilirubin (ALBI)/modified ALBI (mALBI) grade, and O-PNI for Chemotherapy grade (OPNIC grade 1/2/3: O-PNI >40/≤40 to >36/≤36). Results: The MST and TTP were

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nutritional Index as Prognostic Indicator in Patients Receiving Lenvatinib Treatment for Unresectable Hepatocellular Carcinoma

et al. 2020

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“…Table summarizes the results of recent reports evaluating the prognostic value of PNI . The primary sites of cancer reported were kidney in five studies, UUT in one study, urinary bladder in one study and prostate in one study.…”

Section: Combination Markers Of Serum Proteins and Differential Bloodmentioning

confidence: 99%

“…Table 14 summarizes the results of recent reports evaluating the prognostic value of PNI. [158][159][160][161][162][163][164][165][166] The primary sites of cancer reported were kidney in five studies, UUT in one study, urinary bladder in one study and prostate in one study. The cut-off value for high versus low PNI varied from 41 to 51.…”

Section: Pni In Urological Cancersmentioning

confidence: 99%

Role of systemic inflammatory response markers in urological malignancy

Ohno

2018

Int J of Urology

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The systemic inflammatory response is associated with survival in patients with a variety of cancers. This inflammatory response is measured in the peripheral blood, and can be monitored using two categories of indices: concentration of specific serum proteins (albumin, C‐reactive protein) and differential blood cell count (neutrophils, lymphocytes and platelets). Furthermore, combinations of these indices, such as the Glasgow Prognostic Score, which consists of the serum C‐reactive protein and albumin level; the neutrophil‐to‐lymphocyte ratio; the platelet‐to‐lymphocyte ratio; and the prognostic nutritional index, which is based on peripheral blood lymphocyte count and serum albumin level, have also been evaluated and compared in cancer research. To date, there are hundreds of studies that have shown the prognostic value of systemic inflammatory response markers in patients with urological cancer. Most studies have evaluated the prognostic and predictive role of the pretreatment value of the markers, although some have focused on the role of the post‐treatment value at specific points during the clinical course. The advantages of systemic inflammatory response markers are that they are easily measurable and inexpensive in the clinical setting. However, it is important to consider how clinicians use these markers in clinical practice. The present review provides a concise overview regarding systemic inflammatory markers in urological cancers, specifically C‐reactive protein, Glasgow Prognostic Score/modified Glasgow Prognostic Score, neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio and prognostic nutritional index.

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“…Onodera and colleagues [8] simplified the PNI using serum albumin levels and peripheral lymphocyte count and reported that a low PNI score was significantly associated with major postoperative complications and poor prognosis after gastrointestinal surgery. To date, low PNI status has been reported as a predictor of both postoperative complications and poor prognosis in various types of malignancies [9][10][11][12][13][14][15]. However, few studies have been performed with respect to NSCLC [16][17][18][19], and the clinical significance of PNI remains uncertain.…”

mentioning

confidence: 99%

Clinical Significance of Prognostic Nutritional Index After Surgical Treatment in Lung Cancer

Okada

Shimada

Kato

et al. 2017

The Annals of Thoracic Surgery

118

103

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Onodera's Prognostic Nutritional Index as an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma

Cited by 47 publications

References 28 publications

Nutritional Index as Prognostic Indicator in Patients Receiving Lenvatinib Treatment for Unresectable Hepatocellular Carcinoma

Nutritional Index as Prognostic Indicator in Patients Receiving Lenvatinib Treatment for Unresectable Hepatocellular Carcinoma

Role of systemic inflammatory response markers in urological malignancy

Clinical Significance of Prognostic Nutritional Index After Surgical Treatment in Lung Cancer

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