Onset of Action and Efficacy of Ibuprofen Liquigel as Compared to Solid Tablets: A Systematic Review and Meta-Analysis

Lawati, Hanan Al; Jamali, Fakhreddin

doi:10.18433/j3b897

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…Finally, the oral meloxicam used in the current study was in liquid suspension formulation compared with previous research that employed tabular meloxicam. Relative to tablet formulations, liquid NSAIDs may offer faster absorption and earlier onset of action [23].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Delivery Method on the Pharmacokinetic Properties of Meloxicam in Pre-Weaned Dairy Calves with Diarrhea

Shock¹,

Roche²,

Nagel³

et al. 2020

OJVM

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The non-steroidal anti-inflammatory drug meloxicam is commonly used as adjunct therapy for neonatal calf diarrhea to control pain and inflammation. The objective of this study was to compare the pharmacokinetics of meloxicam in diarrheic pre-ruminant dairy calves dosed either orally or subcutaneously. Twelve pre-ruminant male dairy calves with mild to moderate diarrhea were randomly assigned to receive one of four treatments (three per group): subcutaneous meloxicam (SM, 0.5 mg/kg body weight); an oral bolus meloxicam suspension (OM, 1 mg/kg body weight); an oral meloxicam suspension added to a feeding of oral electrolytes (EM, 1 mg/kg body weight); and an oral meloxicam suspension added to a feeding of milk replacer (MM, 1 mg/kg body weight). The predicted pharmacokinetic parameters for OM, MM, EM, and SM groups were: half-life (56.8 ± 21.7 vs. 136.0 ± 26.6 vs. 85.2 ± 21.7 vs. 36.3 ± 21.7 h), Cmax (4.3 ± 0.4 vs. 3.7 ± 0.4 vs. 3.9 ± 0.4 vs. 2.1 ± 0.4 µg/mL), Tmax (13.3 ± 4.0 vs. 10.7 ± 4.0 vs. 13.3 ± 4.0 vs. 2.7 ± 4.0 h), and AUC 0-∞ (383.4 ± 126.8 vs. 877.8 ± 155.3 vs. 457.1 ± 126.8 vs. 126.4 ± 126.8 h * µg/mL). Oral meloxicam, especially MM, had extended elimination phases relative to SM. All meloxicam therapies provided effective therapeutic levels but all oral therapies (1 mg/kg) provided longer durations of activity than injectable meloxicam (0.5 mg/kg).

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Section: Discussionmentioning

confidence: 99%

The Effect of Delivery Method on the Pharmacokinetic Properties of Meloxicam in Pre-Weaned Dairy Calves with Diarrhea

Shock¹,

Roche²,

Nagel³

et al. 2020

OJVM

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“…The age of onset was atypical, but primary CH has been reported in all age groups [8]. The patient did not notice a significant response to ibuprofen, which was not surprising, since CH attacks are short-lived and, therefore, oral routes of administration are not expected to be effective (ibuprofen onset of action is usually thirty minutes to one hour after administration [9], corresponding to the duration of the untreated attacks). Concerning prophylactic therapy, the patient did not present response to verapamil, but the administered dose (40 mg, three times a day) was the lowest effective in preventing this type of headache, and higher doses are usually required [10].…”

Section: Discussionmentioning

confidence: 99%

Cluster-Like Headache Secondary to Sphenoid Sinus Mucocele

Branco

Rodrigues

Lopes

et al. 2018

Case Reports in Neurological Medicine

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Background The great majority of cases of cluster headache (CH) are primary, but there are several reported cases of CH secondary to underlying structural lesions. The identification of these lesions is crucial for the achievement of an effective treatment and favorable outcome, although the determination of a cause-effect relationship between the two entities may be challenging. Case Report We present the first case of CH secondary to sphenoid sinus mucocele. Discussion This case reinforces the need to perform neuroimaging studies in CH patients in order to identify lesions that can constitute its cause, especially if atypical features are present. Activation of the trigeminovascular system due to direct contact between the lesion and the trigeminal nerve or by local edema and inflammation possibly plays a role in the pathophysiology of this CH secondary to sphenoid sinus mucocele.

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“…The propensity of drug precipitation during various stages of the dilution process which takes place during passage in the gut was investigated in various reports (Hasan et al, 2015;Hasan, 2019a;Mohsin and Alanazi, 2012;Mohsin et al, 2009;Porter et al, 2004). Despite the in vitro substantiated evidence of the propensity of the drug to come out of solution due to the hydrophilic nature of lipid vehicle, we have marketed products based on cosolvent systems such as Ibuprofen liquigel (Nurofen ® by GSK or Advil ® by Pfizer) (Al Lawati and Jamali, 2016) and free oil system as in Agenerase ® (Rahman et al, 2012). These hydrophilic systems have shown reasonable bioavailability profiles albeit with the high possible inclination of drug crashing out during in vitro assessment studies.…”

Section: Solvent Capacity Of Self-microemulsifying Systemsmentioning

confidence: 99%

Impact of a formulation design on resultant dispersions of self-microemulsifying lipid systems

Hasan¹

2021

J Appl Pharm Sci

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There is growing interest in the field of self-emulsifying lipid-based technology (SELBT) as an approach to enhance the bioavailability of poorly water-soluble drugs. As a result, the market has witnessed the introduction of more than 30 commercial products based on SELBT. In this investigation, key elements in the formulation design of oil systems which influence vehicle polarity and thus resultant dispersion profiles were optimized. Self-emulsification studies, particle size analysis, and phase behavior studies were carried out with and without drugs. Profiles were compared with commercial Ibuprofen liquigel capsules. Various factors including type of oil, cosurfactant, surfactant, cosolvent, and amount of loaded drug were found to influence dispersion profiles of the self-emulsifying lipid-based system. Furthermore, a significant correlation between total HLB of oil mix and mean emulsion droplet size of resultant aqueous dispersion was established. Also, emulsification of commercial Ibuprofen liquigel capsules has revealed drug precipitation, while self-microemulsifying lipid systems kept the drug in a dissolved state. In conclusion, despite the in vitro apparent failure of cosolvent-based formulation as in commercial Ibuprofen liquigel, these systems still have valid pharmacokinetic profiles.

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Onset of Action and Efficacy of Ibuprofen Liquigel as Compared to Solid Tablets: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 45 publications

The Effect of Delivery Method on the Pharmacokinetic Properties of Meloxicam in Pre-Weaned Dairy Calves with Diarrhea

The Effect of Delivery Method on the Pharmacokinetic Properties of Meloxicam in Pre-Weaned Dairy Calves with Diarrhea

Cluster-Like Headache Secondary to Sphenoid Sinus Mucocele

Impact of a formulation design on resultant dispersions of self-microemulsifying lipid systems

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