Onset of Crohnʼs Disease After Bariatric Surgery in 3 Patients

Sonpal, Niket; Vinod, Jeevan; Felder, Joseph B.; Korelitz, Burton I.

doi:10.14309/00000434-201010001-00996

Cited by 1 publication

(3 citation statements)

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“…None of these patients experienced symptoms prior to the surgery, nor did they have a family history of inflammatory bowel disease [9], as is the same with our patient. All of the patients experienced improved symptoms with immune suppressant and salicylate treatment [10].…”

Section: Discoverance Of Inflammatory Bowel Diseasementioning

confidence: 98%

“…The combination of afferent limb stasis and decreased gastric acidity following Roux-en-Y gastric bypass is felt to predispose to bacterial over growth [3]. It has been suggested that this altered bacterial microbiome of the gut, activates the immune system, triggering chronic intestinal inflammation in the form of Crohn's disease [9,10]. Since this phenomenon is only apparent in a small minority of bariatric patients, it is possible that genetic predisposition may play a role in susceptibility [10].…”

Section: Discoverance Of Inflammatory Bowel Diseasementioning

confidence: 99%

“…It has been suggested that this altered bacterial microbiome of the gut, activates the immune system, triggering chronic intestinal inflammation in the form of Crohn's disease [9,10]. Since this phenomenon is only apparent in a small minority of bariatric patients, it is possible that genetic predisposition may play a role in susceptibility [10]. Further workup will be necessary for a definite diagnosis of Crohn's disease.…”

Section: Discoverance Of Inflammatory Bowel Diseasementioning

confidence: 99%

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Heterotopic gastric mucosa and possible new onset Crohn’s disease causing stricture in bariatric patient

Stalin¹

2018

Ann Bariatr Metab Surg

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A 51-year old Caucasian female had presented with intractable Gastroesophageal Reflux Disease (GERD), chronic dysphagia and food intolerance over a period of 6 years following a sleeve gastrectomy. With conservative management options having failed she underwent a Revisional Roux-en-Y gastric bypass. Although the patient did well initially, she developed dysphagia once again with her BMI falling to 17.7 (initial BMI 44.6). Upper endoscopy showed a patent anastomosis but with a stricture in the roux limb and an ulcer distal to that stricture with no marginal ulceration at the anastomosis itself. Workup resulted in increased suspicion for carcinoid tumor and Inflammatory Bowel Disease (IBD) due to elevated chromogranin A, Single Photon Emission Computed Tomography (SPECT) study and elevated fecal calprotectin respectively. Final pathology of the stricture was positive for gastric mucosa which was subsequently excised. Two months later, abdominal pain and signs of dehydration led to a small bowel series X-ray with barium showing high suspicion for Crohn's disease.

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Section: Discoverance Of Inflammatory Bowel Diseasementioning

confidence: 98%