Onset of Depression in Elderly Persons After Hip Fracture: Implications for Prevention and Early Intervention of Late‐Life Depression

Lenze, Eric J.; Munin, Michael C.; Skidmore, Elizabeth R.; Dew, Mary Amanda; Rogers, Joan C.; Whyte, Ellen M.; Quear, Tanya; Begley, Amy; Reynolds, Charles F.

doi:10.1111/j.1532-5415.2006.01017.x

Cited by 97 publications

(133 citation statements)

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“…66 In the period after a hip fracture, 15% of older adults meet criteria for major depression, and half will have elevated depressive symptoms. 67 In some individuals, a high level of distress immediately after the injury improves over time. 68 In a smaller proportion, depressive symptoms seem to arise as their recovery plateaus and they are faced with enduring deficits.…”

Section: Depression Antidepressants and Fracturesmentioning

confidence: 99%

“…71 Age, medical comorbidity, level of disability before and after the fracture, apathy, delirium, cognitive impairment, and poor social support are all risk factors for the development of depression after hip fracture. 67 Use of an antidepressant at baseline, perhaps an indicator of a history of depression, is also a risk factor. 67 Gene polymorphisms in serotonin transporter and 5HT-1A receptor, markers of vulnerability to stress, have also been implicated in the development of depression and impaired function after a hip fracture.…”

Section: Depression Antidepressants and Fracturesmentioning

confidence: 99%

“…67 Use of an antidepressant at baseline, perhaps an indicator of a history of depression, is also a risk factor. 67 Gene polymorphisms in serotonin transporter and 5HT-1A receptor, markers of vulnerability to stress, have also been implicated in the development of depression and impaired function after a hip fracture. 72,73 The presence of depressive symptoms prefracture may also be a risk factor for loss of functional status.…”

Section: Depression Antidepressants and Fracturesmentioning

confidence: 99%

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The Complex Interplay of Depression and Falls in Older Adults: A Clinical Review

Iaboni

Flint

2013

The American Journal of Geriatric Psychiatry

227

178

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Depression and falls have a significant bidirectional relationship. Excessive fear of falling, which is frequently associated with depression, also increases the risk of falls. Both depression and fear of falling are associated with impairment of gait and balance, an association that is mediated through cognitive, sensory, and motor pathways. The management of depression in fall-prone individuals is challenging, since antidepressant medications can increase the risk of falls, selective serotonin reuptake inhibitors may increase the risk of fragility fractures, and data are lacking about the effect of fall rehabilitation programs on clinically significant depression. Based on the current state of knowledge, exercise (particularly Tai Chi) and cognitive-behavioral therapy should be considered for the first-line treatment of mild depression in older fallers. Antidepressant medications are indicated to treat moderate to severe depression in fall-prone individuals, but with appropriate precautions including low starting dose and slow dose titration, use of psychotropic monotherapy whenever possible, and monitoring for orthostatic hypotension and hyponatremia. To date, there have been no recommendations for osteoporosis monitoring and treatment in individuals prescribed antidepressant medications, beyond the usual clinical guidelines. However, treatment of the older depressed person who is at risk of falls provides the opportunity to inquire about his or her adherence with osteoporosis and fracture-prevention guidelines. KeywordsAntidepressants; depression; falls; fear of falling; fractures One-third of community-dwelling seniors fall each year, with half of these individuals falling more than once. Ten percent of all falls result in a major injury, which can lead to institutionalization and death. 1 Falls often result in a fear of further falls, leading to fearrelated restriction of activities: this activity restriction has been associated with subsequent impairment in balance, mobility, and disability. 2,3 Send correspondence and reprint requests to Alastair

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Section: Depression Antidepressants and Fracturesmentioning

confidence: 99%

Section: Depression Antidepressants and Fracturesmentioning

confidence: 99%

Section: Depression Antidepressants and Fracturesmentioning

confidence: 99%

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The Complex Interplay of Depression and Falls in Older Adults: A Clinical Review

Iaboni

Flint

2013

The American Journal of Geriatric Psychiatry

227

178

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“…Additionally, 11 domain-specific measures were reviewed: three measures of emotional wellbeing -Geriatric Depression Scale (GDS) [42], Hamilton Rating Scale for Depression (HAM-D) [43] and the Zung Depression Inventory (ZungDI) [44]; and eight measures of (instrumental) activities of daily living (I/ADL): Barthel Index (BI) [45], Modified-Barthel Index [46], Functional Activities Index (FAI) [47], Functional Independence Measure (FIM) [48], Functional Status Questionnaire (FSQ) [49], Lawton IADL scale (Lawton-IADL) [50], Katz Index of Independence in ADL (Katz ADL) [51] and the OARS Multi-dimensional Functional Assessment Questionnaire (OMFAQ) [52]. One of these measures (Katz ADL) is clinician-completed but was included in the review due to its wide-spread use in this patient population.…”

Section: [Type Here]mentioning

confidence: 99%

Patient-reported outcome measures in older people with hip fracture: a systematic review of quality and acceptability

et al. 2016

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Purpose: Hip fracture is the most common serious injury of older people, often resulting in reduced mobility and loss of independence. However, guidance for the use of patient-reported outcome measures (PROMs) does not exist: we describe the first review to apply internationally endorsed criteria in support of PROM quality and acceptability in this group, and make recommendations for future applications.Methods: Systematic literature searches of major databases to identify published evidence of the application and quality of clearly defined measures. Evidence of measurement and practical properties, and the extent of active patient involvement, was sought. Study and PROM quality was assessed against recommended criteria.Results: 71 articles relating to 28 PROMs (Generic n=12; Specific n=16) were included. The SF-36 (v1) and EuroQoL EQ-5D 3L were the most widely evaluated measures with acceptable evidence of measurement properties, but limited evaluations of practical properties or relevance to this group. Evidence was mostly limited for the remaining measures. Hypothesized associations between variables were infrequently evaluated. Evidence of data quality, test-retest reliability, responsiveness, interpretation, acceptability and feasibility was also limited. Active patient involvement in PROM development or evaluation was not reported. There was limited evaluation of proxy completions. Conclusions:The paucity of robust evaluations is disappointing and prevents clear recommendations for PROM-based assessment. Further research must urgently seek to identify which outcomes really matter to this group. Future PROM selection must be underpinned by research which focuses on methodological quality, including issues of acceptability, relevance, feasibility of application, and proxy completion, whilst seeking to actively incorporate the perspective of patients and their advocates. Authors:Haywood KL, Brett J, Tutton E, Staniszewska S. Title:Patient-reported outcome measures in older people with hip fracture: a systematic review of quality and acceptability. Affiliation(s) and addresse(s):Haywood Abstract (257/250)Purpose: Hip fracture is the most common serious injury of older people, often resulting in reduced mobility and loss of independence. However, guidance for the use of patient-reported outcome measures (PROMs) does not exist: we describe the first review to apply internationally endorsed criteria in support of PROM quality and acceptability in this group, and make recommendations for future applications.Methods: Systematic literature searches of major databases to identify published evidence of the application and quality of clearly defined measures. Evidence of measurement and practical properties, and the extent of active patient involvement, was sought. Study and PROM quality was assessed against recommended criteria.Results: 71 articles relating to 28 PROMs (Generic n=12; Specific n=16) were included. The and EuroQoL EQ-5D 3L were the most widely evaluated measures with acceptable evidence of ...

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“…Isso ocorre provavelmente pelo efeito estressante associado à fratura incluindo sequelas, dor, imobilização, hospitalização e cirurgias. Um estudo prospectivo com 126 idosos revelou que o período de maior risco para surgimento da depressão foi nas primeiras 10 semanas após a fratura 15 .…”

Section: Fratura De Quadril Como Fator De Risco Para a Depressãounclassified

Prevalência de depressão em mulheres idosas com fratura de quadril

Demetrio

Gattaz

et al. 2009

Rev. psiquiatr. clín.

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Onset of Depression in Elderly Persons After Hip Fracture: Implications for Prevention and Early Intervention of Late‐Life Depression

Cited by 97 publications

References 54 publications

The Complex Interplay of Depression and Falls in Older Adults: A Clinical Review

The Complex Interplay of Depression and Falls in Older Adults: A Clinical Review

Patient-reported outcome measures in older people with hip fracture: a systematic review of quality and acceptability

Prevalência de depressão em mulheres idosas com fratura de quadril

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