Abstract. In this PhD tutorial article, we present experiments with quantum degenerate mixtures of fermionic and bosonic atoms in 3-dimensional optical lattices. This heteronuclear quantum gas mixture offers a wide range of possibilities for quantum simulation, implementation of condensed matter Hamiltonians, quantum chemistry and ultimately dense and quantum degenerate dipolar molecular samples.We When loaded into a 3D optical lattice, a whole zoo of novel quantum phases has been predicted for Fermi-Bose mixtures. We present the first realization of Fermi-Bose mixtures in 3D optical lattices as a novel quantum many body system [3]. We study the phase coherence of the bosonic cloud in the 3D optical lattice as a function of the amount of fermionic atoms simultaneously trapped in the lattice. We observe a loss of phase coherence at much lower lattice depth than for a pure bosonic cloud and discuss possible theoretical scenarios including adiabatic processes, mean field FermiBose Hubbard scenarios, and disorder-enhanced localization scenarios.After considering this many-body limit of mixtures in lattices, we show how fermionic heteronuclear Feshbach molecules can be created in the optical lattice [4] as a crucial step towards all ground state dense dipolar molecular samples. We develop rf association as a novel molecule association technique, measure the binding energy, lifetime, and association efficiency of the molecules. We develop a simple theoretical single channel model of the molecules trapped in the lattice [5] which gives excellent quantitative agreement with the experimental data.