Onset of oral lichen planus following dental treatments: A nested case–control study

Sheng‐Kai, Kevin; Thota, Eshwar; Huang, Jing‐Yang; Huang, Yu‐Feng; Wei, James Cheng‐Chung

doi:10.1111/odi.14115

Cited by 13 publications

(9 citation statements)

References 57 publications

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“…That being said, in relation to the previous studies, our major strengths include a fairly large sample size from a real‐world population‐based setting. Also, propensity score matching was adopted in this study to minimize the effect of potential confounding factors on the presented association 39,40 . On the other hand, because the findings of this study were validated through verifying the findings in a subpopulation that had received periodontal therapy, we accordingly proposed a significant time‐dependent association between tonsillectomy and subsequent risk of aggressive or acute periodontitis that led to surgical or mechanical treatments.…”

Section: Discussionmentioning

confidence: 93%

Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Sheng‐Kai

Thota

et al. 2022

Journal of Periodontology

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Background To determine whether patients who had undergone tonsillectomy would have higher risks of postoperative periodontitis. Methods Data were collected from the Taiwan Longitudinal Health Insurance Dataset from 1999 to 2013, a population‐based cohort study consisting of cases of newly‐onset sleep apnoea, chronic diseases of tonsils and adenoids, peritonsillar abscess, and periodontal diseases. A total of 1482 tonsillectomy cases and 14,796 non‐tonsillectomy controls were selected. Propensity score matching37 between the tonsillectomy group and the non‐tonsillectomy group was conducted to exclude the confounding effect resulting from indications of tonsillectomy. Cox proportional hazard model and subgroup analyses were conducted to identify subpopulations at risk of tonsillectomy‐associated periodontitis, and a sub‐outcome analysis was applied to identify the subtype of tonsillectomy‐associated periodontitis. Results A total of 648 patients who had undergone tonsillectomy and 648 out of 6509 propensity score‐matched controls were retrieved, among which 230 cases in the tonsillectomy group were associated with post‐surgical periodontitis (adjusted HR = 1.31, 95% CI = 1.08 to 1.59). The association persisted in a subpopulation of patients with periodontitis who received mechanical and surgical treatments for periodontitis (adjusted HR = 1.33, 95% CI = 1.09 to 1.63). The incidence of periodontitis was significantly high in the individuals who underwent tonsillectomy and was particularly high in those that were below 12 years of age (HR = 1.58, 95% CI = 1.10 to 2.27). The risk of periodontitis increased 4 years after tonsillectomy (HR = 1.82; 95% CI = 1.29 to 2.59). The majority of post‐tonsillectomy periodontitis was aggressive and acute periodontitis (HR = 1.37; 95% CI = 1.10 to 1.71). Conclusions Tonsillectomy performed in pediatric patients of < 12 years old, increased the risk of developing periodontitis. Aggressive and acute periodontitis as a long‐term, postoperative adverse event took place at 4 years or longer after tonsillectomy.

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Section: Discussionmentioning

confidence: 93%

Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Sheng‐Kai

Thota

et al. 2022

Journal of Periodontology

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“…In this cohort study, we employed a nationwide population-based registry to provide epidemiological evidence on the risks of new-onset ED in patients with HPV infection. The effect of measurable confounders was minimized by PS matching [ 71 , 72 , 73 , 74 , 75 ]. Sensitivity and negative control analyses were conducted to manage residual confounding and to ascertain the impact of HPV infection on ED development.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection and the Risk of Erectile Dysfunction: A Nationwide Population-Based Matched Cohort Study

Juang

Sheng‐Kai

Kao

et al. 2022

JPM

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Background: Male patients with genital warts are known for higher rates of sexual dysfunction. This study was conducted to investigate whether human papillomaviruses (HPV) infection is associated with an increased risk of erectile dysfunction (ED). Methods: Patients aged over 18 with HPV infection (n = 13,296) and propensity score-matched controls (n = 53,184) were recruited from the Longitudinal Health Insurance Database (LHID). The primary endpoint was the diagnosis of ED. Chi-square tests were used to analyze the distribution of demographic characteristics. The Cox proportional hazards regression was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the development of ED in both groups, after adjusting for sex, age, relevant comorbidities, co-medication, and surgery. Results: ED developed in 181 patients of the study group. The incidence density of ED was 2.53 per 1000 person-years for the HPV group and 1.51 per 1000 person-years for the non-HPV group, with an adjusted HR (95% CI) of 1.63 (1.37–1.94). In stratification analysis, adjusted HR of diabetes-, chronic obstructive pulmonary disease (COPD-), and stroke-subgroup were 2.39, 2.51, and 4.82, with significant p values for interaction, respectively. Sensitivity analysis yields consistent findings. Conclusions: The patients with HPV infection had a higher risk of subsequent ED in comparison to the non-HPV controls. The mechanism behind such association and its possible role in ED prevention deserves further study in the future.

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“…The diagnosis of osteoarthritis, which was the primary outcome of the periodontitis cohort, was made following the American College of Rheumatology (ACR) diagnostic criteria for osteoarthritis of the hand ( 26 ), hip ( 27 ), and knee ( 28 , 29 ). A sensitivity analysis restricting the outcome of interest to only severe osteoarthritis that resulted in TKR or total hip replacement (THR) was conducted, for which osteoarthritis had to be the main diagnosis in the discharge notes of TKR/THR.…”

Section: Methodsmentioning

confidence: 99%

“…The propensity score match using strata was performed by adjusting for age, gender, socioeconomic variables, including income, occupation, and healthcare accessibility in the residential area, underlying comorbidities, including systemic lupus erythematosus (SLE), RA, obesity, DM, hypertension, hyperlipidaemia, chronic liver disease, osteonecrosis, Paget's disease, and hypothyroidism, and the year of periodontitis onset or matched-year for controls, to control for confounding factors between the periodontitis and non-periodontitis groups. The propensity score is a probability estimated through logistic regression (27)(28)(29)(30), with which the cases and controls were matched on a 1:1 basis. To ensure the selection of the matched periodontitis and non-periodontitis cases was not biased, standard mean difference (SMD) was derived for the comparison between the cases and the controls.…”

Section: Study Design and Data Sourcesmentioning

confidence: 99%

Bidirectional Relationship Between Osteoarthritis and Periodontitis: A Population-Based Cohort Study Over a 15-year Follow-Up

et al. 2022

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ObjectiveTo identify the relationship between osteoarthritis and periodontitis.Methods144,788 periodontitis patients and 144,788 propensity score-matched controls without history of periodontitis were enrolled in this cohort study. A Cox proportional hazard model was used to estimate the risk of osteoarthritis. Survival analysis was utilized to assess the time-dependent effect of periodontitis on osteoarthritis. Age and gender were stratified to identify subgroups at risk. A symmetrical case-control analysis was designed to determine the relationship between present periodontitis and history of osteoarthritis.ResultsPatients with periodontitis had higher risk of osteoarthritis (hazard ratio, HR =1.15, 95% CI =1.12–1.17, p < 0.001) and severe osteoarthritis that led to total knee replacement or total hip replacement (TKR/THR) (HR =1.12, 95% CI =1.03–1.21, p < 0.01) than controls, which was time-dependent (log-rank test p < 0.01). The effect of periodontitis on osteoarthritis was significant in both genders and age subgroups over 30 years-old (all p < 0.001). Among them, females (HR=1.27, 95% CI = 1.13–1.42, p < 0.001) and patients aged over 51 (HR= 1.21, 95% CI =1.10-1.33, p < 0.001) with periodontitis were predisposed to severe osteoarthritis. In addition, periodontitis patients were more likely to have a history of osteoarthritis (odds ratio = 1.11, 95% CI = 1.06 - 1.17, p < 0.001).ConclusionsThese findings suggest an association between periodontitis and a higher risk of osteoarthritis, including severe osteoarthritis that led to TKR/THR. Likewise, periodontitis is more likely to develop following osteoarthritis. A bidirectional relationship between osteoarthritis and periodontitis was observed.

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Onset of oral lichen planus following dental treatments: A nested case–control study

Abstract: Oral lichen planus (OLP) is a common mucocutaneous, inflammatory disease, as prevalent as up to 1-2% of the population. It is most prevalent among females older than 40 years old with a male: female

Cited by 13 publications

References 57 publications

Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Human Papillomavirus Infection and the Risk of Erectile Dysfunction: A Nationwide Population-Based Matched Cohort Study

Bidirectional Relationship Between Osteoarthritis and Periodontitis: A Population-Based Cohort Study Over a 15-year Follow-Up

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