Ontogenesis of Circadian Pituitary-Adrenal Periodicity in Rats Affected by Neonatal Treatment wth ACTH

Lorenz, Robert J.; Branch, Berrilyn J.; Taylor, A.N.

doi:10.3181/00379727-145-37845

Cited by 9 publications

(2 citation statements)

References 4 publications

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“…The present data would imply that neonatal hydrocortisone administration delayed, but did not prevent, the appearance of the normal circadian periodicity of plasma corticosteroid levels. In contrast to these findings, Lorenz et al [1974] have very re cently reported a diminished (although not absent) circadian variation in plasma corticosteroid levels in adult male and female 120-day-old animals which had received 0.4 IU/g body weight ACTH gel on postnatal days 7-9, as well as in adult female animals receiving gel vehicle alone on days 17-19. Only two sampling points in the 24-h cycle were utilized in these periodicity studies.…”

Section: Discussionmentioning

confidence: 57%

Effect of Neonatal Hydrocortisone on Corticosteroid Circadian Periodicity, Responsiveness to ACTH and Stress in Prepuberal and Adult Rats

Krieger¹

1974

Neuroendocrinology

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500 µg hydrocortisone acetate was administered subcutaneously to 2-day-old male and female rats. Study of these animals at 30 days of age revealed virtual obliteration of the circadian periodicity of plasma corticosteroid levels, but preservation of normal adrenal responsiveness to ACTH and to the stresses of immobilization and etherization. Circadian periodicity was normal in both male and female animals studied at 80 days of age. The other cited parameters were tested only in male animals at this age, and again were found to be normal. These studies indicate (1) a dissociation between the effects of neonatal corticosteroid administration on corticosteroid periodicity and corticosteroid responsiveness to ACTH and stress; and (2) the lack of permanence of the effects on corticosteroid periodicity.

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Section: Discussionmentioning

confidence: 57%

Effect of Neonatal Hydrocortisone on Corticosteroid Circadian Periodicity, Responsiveness to ACTH and Stress in Prepuberal and Adult Rats

Krieger¹

1974

Neuroendocrinology

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“…Analogous organizational effects on the brain-pituitaryadrenal axis by glucocorticoids and ACTH administration have been reported (Krieger, 1972(Krieger, , 1974Lorenz, Branch & Taylor, 1974;Turner & Taylor, 1976). Corticosterone, the predominant glucocorticoid in the rat, differentially alters pituitary-adrenal function : transient and permanent lowering of plasma corticosterone levels were found in animals treated during the 1st week after birth and attenuation of diurnal fluctuations in plasma corticosterone was produced by treatment on Day 18 of age (Turner & Taylor, 1976).…”

Section: Introductionmentioning

confidence: 90%

Effects of postnatal corticosterone treatment on reproductive development in the rat

Turner¹,

Taylor²

1977

Reproduction

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Reproductive development was studied in rats in which corticosterone (25 mg/100 g body wt) mixed with an equal amount of cholesterol was implanted i.p. at Days 3, 6, 12 or 18 after birth. Vaginal perforation in rats treated on Days 12 or 18 was advanced by 10 days but reproductive function in the treated animals was generally disrupted. A variable incidence of persistent vaginal oestrus was observed in adult females given implants on Days 3 and 6, and of prolonged vaginal dioestrus in those treated on Days 12 or 18. All treated females had lordosis quotients lower than those of untreated controls, the effect being most pronounced at the earlier ages of treatment. The results are believed to indicate two periods in reproductive development which are differentially affected by corticosterone.

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Ontogeny of Circadian Rhythms

Davis

1981

Biological Rhythms

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Ontogenesis of Circadian Pituitary-Adrenal Periodicity in Rats Affected by Neonatal Treatment wth ACTH

Cited by 9 publications

References 4 publications

Effect of Neonatal Hydrocortisone on Corticosteroid Circadian Periodicity, Responsiveness to ACTH and Stress in Prepuberal and Adult Rats

Effect of Neonatal Hydrocortisone on Corticosteroid Circadian Periodicity, Responsiveness to ACTH and Stress in Prepuberal and Adult Rats

Effects of postnatal corticosterone treatment on reproductive development in the rat

Ontogeny of Circadian Rhythms

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