Ontogenesis of circadian sleep-wakefulness rhythms and developmental changes of sleep in the altricial rat and in the precocial guinea pig

Ibuka, Nobuo

doi:10.1016/0166-4328(84)90210-9

Cited by 45 publications

(26 citation statements)

References 20 publications

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“…The pattern was reversed by P29, with higher REM sleep amounts during the light vs. the dark phase. These results are in agreement with two previous studies of diurnal distribution of sleep-wake states in rats at similar postnatal ages (1,26).…”

Section: Discussionsupporting

confidence: 83%

“…The animals were first housed by pairs in small acrylic cages containing bedding from their home cage and transferred to the recording room. The cages were placed in environmental chambers (Fisher Scientific, Pittsburgh, PA) at an age-appropriate temperature (P18: 25°C; P19: 24°C; P20 -P30: 22°C) (1,13,26). The light-dark cycle was kept the same as in the animal house (6:00 A.M.-6:00 P.M., with lights on at 6:00 A.M.).…”

Section: Animals and Experimental Environmentmentioning

confidence: 99%

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Maturation of sleep homeostasis in developing rats: a role for preoptic area neurons

Gvilia

Suntsova

Angara

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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Gvilia I, Suntsova N, Angara B, McGinty D, Szymusiak R. Maturation of sleep homeostasis in developing rats: a role for preoptic area neurons. Am J Physiol Regul Integr Comp Physiol 300: R885-R894, 2011. First published February 16, 2011 doi:10.1152/ajpregu.00727.2010.-The present study evaluated the hypothesis that developmental changes in hypothalamic sleepregulatory neuronal circuits contribute to the maturation of sleep homeostasis in rats during the fourth postnatal week. In a longitudinal study, we quantified electrographic measures of sleep during baseline and in response to sleep deprivation (SD) on postnatal days 21/29 (P21/29) and P22/30 (experiment 1). During 24-h baseline recordings on P21, total sleep time (TST) during the light and dark phases did not differ significantly. On P29, TST during the light phase was significantly higher than during the dark phase. Mean duration of non-rapideye-movement (NREM) sleep bouts was significantly longer on P29 vs. P21, indicating improved sleep consolidation. On both P22 and P30, rats exhibited increased NREM sleep amounts and NREM electroencephalogram delta power during recovery sleep (RS) compared with baseline. Increased NREM sleep bout length during RS was observed only on P30. In experiment 2, we quantified activity of GABAergic neurons in median preoptic nucleus (MnPN) and ventrolateral preoptic area (VLPO) during SD and RS in separate groups of P22 and P30 rats using c-Fos and glutamic acid decarboxylase (GAD) immunohistochemistry. In P22 rats, numbers of Fos ϩ GAD ϩ neurons in VLPO did not differ among experimental conditions. In P30 rats, Fos ϩ GAD ϩ counts in VLPO were elevated during RS. MnPN neuronal activity was state-dependent in P22 rats, but Fos ϩ GAD ϩ cell counts were higher in P30 rats. These findings support the hypothesis that functional emergence of preoptic sleep-regulatory neurons contributes to the maturation of sleep homeostasis in the developing rat brain. postnatal development; sleep-promoting systems; sleep homeostasis; preoptic hypothalamus SLEEP IN ADULT MAMMALS is homeostatically regulated. Rats exhibit a gradual emergence of different components of sleep homeostasis during postnatal development (5,14,40,47). Some aspects of sleep homeostasis are present in rats on postnatal day (P) 2, when sleep deprivation (SD) increases sleep time during postdeprivation recovery sleep (47). Postdeprivation increases in non-rapid-eye-movement (NREM) sleep delta (␦) power, a measure of the intensity of homeostatic response in adults (7), are observed in P24 rats but not in P20 rats (14). In developing rats, electroencephalogram (EEG) spectral power in the ␦ frequency (0.5-4.0 Hz) in NREM sleep progressively increases across P10 -P20 (13,22). However, the normal decline in NREM sleep ␦-wave activity during the rest phase, typical of adult rats and reflective of adult sleep homeostasis, is absent in rats younger than P24 (13). The above findings suggest that sleep homeostasis in rats undergoes significant maturation between the third and fourth po...

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Section: Discussionsupporting

confidence: 83%

Section: Animals and Experimental Environmentmentioning

confidence: 99%

Maturation of sleep homeostasis in developing rats: a role for preoptic area neurons

Gvilia

Suntsova

Angara

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Although in the Djungarian hamster NREM sleep is more prominent than in the rat, the amount of REM sleep is similar in these two rodents (Borb+ly and Neuhaus 1979;Friedman et al 1979;Trachsel et al 1988). This contrasts the markedly lower amounts of both NREM sleep and REM sleep in the guinea pig (Ibuka 1984;Tobler et al 1993). NREM sleep episode duration did not differ between the light and the dark period in the Djungarian hamster, which is in contrast with the rat (Franken et al 1992a) and the guinea pig (Tobler et al 1993), where NREM sleep episodes were shorter in the dark period compared with the light period.…”

Section: Discussionmentioning

confidence: 51%

Sleep and cortical temperature in the Djungarian hamster under baseline conditions and after sleep deprivation

1994

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The Djungarian hamster (Phodopus sungorus) is a markedly photoperiodic rodent which exhibits daily torpor under short photoperiod. Normative data were obtained on vigilance states, electroencephalogram (EEG) power spectra (0.25-25.0 Hz), and cortical temperature (TCRT) under a 16:8 h light-dark schedule, in 7 Djungarian hamsters for 2 baseline days, 4 h sleep deprivation (SD) and 20 h recovery. During the baseline days total sleep time amounted to 59% of recording time, 67% in the light period and 43% in the dark period. The 4 h SD induced a small increase in the amount of non-rapid eye movement (NREM) sleep and a marked increase in EEG slow-wave activity (SWA; mean power density 0.75-4.0 Hz) within NREM sleep in the first hours of recovery. TCRT was lower in the light period than in the dark period. It decreased at transitions from either waking or rapid eye movement (REM) sleep to NREM sleep, and increased at the transition from NREM sleep to waking or REM sleep. After SD, TCRT was lower in all vigilance states. In conclusion, the sleep-wake pattern, EEG spectrum, and time course of TCRT in the Djungarian hamster are similar to other nocturnal rodents. Also in the Djungarian hamster the time course of SWA seems to reflect a homeostatically regulated process as was formulated in the two-process model of sleep regulation.

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“…The pattern of circadian activity is not usually 98 present in altricial species at birth (Ibuka, 1984, Kowalska et al, 2010. Rhythms typically 99 appear days or weeks after birth, once the cubs leave the den and are exposed to local 100 environmental factors such as the daylight cycle and temperature.…”

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confidence: 98%

Ontogeny of daily activity and circadian rhythm in the Iberian lynx (Lynx pardinus)

Yerga

Calzada

Manteca

et al. 2015

Applied Animal Behaviour Science

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34The aim of this paper is to describe the ontogeny of the circadian activity rhythms in captive-35 born Iberian lynx (Lynx pardinus) from birth to subadult age and to verify if they develop a 36 bimodal circadian pattern similar to the one they show in the wild. The amount of daily activity 37 and the circadian rhythmicity of 61 Iberian lynx (48 mother-raised and 13 hand-reared) cubs 38 were studied in two breeding centers. During the first month of life, the cubs were active 30% of 39 the day. Activity increased up to 50% during the following two weeks, and then it remained 40 constant until the end of the lynx physical development. The location of the breeding center 41 affected the amount of daily activity of the cubs probably as result of different climatic 42 conditions. Once the lynx cubs had completed their development, there was no difference in the 43 time spent active between wild and captive lynx. Newborns had a constant level of activity 44 throughout the day (24 hours) during the first month of life. During the second month, once they 45 had developed sufficiently to leave the den, a crepuscular bimodal circadian rhythm started to 46 emerge. This pattern was completely defined by the third month of life. The overlap in circadian 47 activity was over 0.88 when comparing the sexes, breeding centers and rearing methods. 48However, there was a significant difference between mother-raised and hand-reared cubs -the 49 latter being more active in the morning-, as well as between breeding centers -again due to 50 climate differences-. Finally, an overlap of 0.85 in circadian activity pattern was observed 51 between wild and captive lynx, although the wild animals were more active at night. 52 53 54

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Ontogenesis of circadian sleep-wakefulness rhythms and developmental changes of sleep in the altricial rat and in the precocial guinea pig

Cited by 45 publications

References 20 publications

Maturation of sleep homeostasis in developing rats: a role for preoptic area neurons

Maturation of sleep homeostasis in developing rats: a role for preoptic area neurons

Sleep and cortical temperature in the Djungarian hamster under baseline conditions and after sleep deprivation

Ontogeny of daily activity and circadian rhythm in the Iberian lynx (Lynx pardinus)

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