1982
DOI: 10.1203/00006450-198207000-00004
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Ontogenesis of Nerve Growth Factor and Epidermal Growth Factor in Submaxillary Glands and Nerve Growth Factor in Brains of Immature Male Mice: Correlation with Ontogenesis of Serum Levels of Thyroid Hormones

Abstract: Summarybetween 11 and 32 days of age. The known increase in mouse serum testosterone to adult male levels between 4-12 wk of age Using specific and sensitive radioimmunoassa~s for may be a factor in the late increase in NGF and EGF elevations growth factor (NGF) and epidermal growth factor (EGF), we after 32 days of age. studied the developmental profde of NGF and EGF concentrations in male mouse submaxillary gland (SMG) from 2-60 days of age. We measured NGF concentrations in mouse cerebellum, cerebral Nerve … Show more

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Cited by 44 publications
(18 citation statements)
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“…A further point of interest pertains to the observation of significant, albeit low concentrations of both NGF and EGF in the neonatal mouse SMG and is in agreement with previous observations (8,25), but not with those of other groups (9,13,26). The reason for this discrepancy is not clear, particularly since the sensitivities of the assay systems are similar.…”
Section: Discussionsupporting
confidence: 66%
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“…A further point of interest pertains to the observation of significant, albeit low concentrations of both NGF and EGF in the neonatal mouse SMG and is in agreement with previous observations (8,25), but not with those of other groups (9,13,26). The reason for this discrepancy is not clear, particularly since the sensitivities of the assay systems are similar.…”
Section: Discussionsupporting
confidence: 66%
“…SMG protease activity also is increased by T4 administration (7). Further, the ontogenetic profiles of SMG NGF and EGF concentrations correlate temporally with those of serum T4 and T3 (8).…”
Section: Discussionmentioning
confidence: 76%
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“…Since urine EGF increases in response to thyroxine (1 8) and endogenous thyroid hormone levels increase steeply between 5 and 15 days (20), the increasing endogenous thyroid hormone levels may be responsible for the massive increase in urine EGF between days 6 and 18. Exogenous growth hormone also increases urine EGF during the 1st wk of life (2 I), and since thyroid hormones are known to stimulate growth hormone secretion, growth hormone may contribute to this ontogenic urine EGF surge.…”
Section: Discussionmentioning
confidence: 99%