Ontogenetic changes in phenolic contents and volatile composition of Hypericum androsaemum and Hypericum xylosteifolium

Çırak, Cüneyt; Seyis, Fatih; Özcan, Aysel; Yurteri, Emine

doi:10.1016/j.bse.2022.104429

Cited by 7 publications

(9 citation statements)

References 79 publications

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“…For instance, shikimic acid is the precursor of aromatic amino acids and phenolic compounds, being more abundant in the early stages. The main sites of chlorogenic acid accumulation were found to be the leaves, and the amount was found to decrease linearly with the progression of phenological stages, with the top level being attained at the vegetative stage [17,18] . H. androsaemum is devoid of the black nodules that are the typical secretory structures where naphtodiantrones such as hypericin and pseudohypericin are produced in other Hypericum species [1,19] .…”

Section: Resultsmentioning

confidence: 96%

“…H. androsaemum contains several types of phenolic compounds, namely phenolic acids, lignans, quinones, xanthones and polycyclic polyprenylated acylphloroglucinols (PPAPs) [1,14,17,20,21] .…”

Section: Resultsmentioning

confidence: 99%

“…They include several esters of caffeic acid and quinic acid, like 5-O-caffeoylquinic acid (chlorogenic acid), 3-O-caffeoylquinic acid (neochlorogenic acid) and 3,5dicaffeoylquinic acid [1,5,9,17,24] . These compounds have been reported to exhibit antidepressant, antioxidant and antiinflammatory effects and to have high potential in the treatment of depression, and improvement of learning and memory [17,25] . H. androsaemum also contains ferulic, fumaric, gallic and rosmarinic acids [5,9,11] .…”

Section: Phenolic Acidsmentioning

confidence: 99%

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Active compounds and biological activities of Hypericum androsaemum L.: A review

Aguiar,

Costa

2023

J Pharmacogn Phytochem

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Hypericum androsaemum L. is a plant renowned in the Mediterranean basin for diuretic, hepatoprotective, anti-hypertensive, anti-hemorrhoidal, anti-depressant and skin-protective effects. This review makes a critical summary of published pharmacognostical data. H. androasemum contains significant amounts of phenolic compounds, namely chlorogenic acids, flavonoids, triterpenoids, polycyclic polyprenylated acylphloroglucinols (PPAPs) and xanthones. Extracts of the plant have shown radical scavenging activity. The fruits' extracts have shown cytotoxic activity against some cancer cell lines. The plant has some immunomodulatory, DNA-protective, anti-glycation, antidepressant and antiinflammatory effects. Given its effect on fibroblasts proliferation and migration, collagenase and tyrosinase inhibitory action, immunomodulatory effect, UV-protective and lack of phototoxicity, it has potential in skin formulas. It has shown biocidal activity against some bacteria, fungi, nematodes, mollusks and insects. At low concentrations, the extracts were nontoxic on normal cells. However, safety issues may arise with oral administration of high hyperforin H. androasemum preparations.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Phenolic Acidsmentioning

confidence: 99%

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Active compounds and biological activities of Hypericum androsaemum L.: A review

Aguiar,

Costa

2023

J Pharmacogn Phytochem

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“…γ-Himachalene is a sesquiterpene known to be immune system supportive in terms of acting as an antioxidant and anti-inflammatory agent and aiding in cellular repair (Taleb et al, 2016). Himachalene isomers were reported in the Hypericum species (Cirak et al, 2022;Jaimand et al, 2012). Therefore, the effective anti-inflammatory activity of the PH could be attributed to the presence of a high concentration of specific compounds with anti-inflammatory activity.…”

Section: Gc-ms Analysismentioning

confidence: 99%

HPLC fingerprinting/GC-MS analysis, and efficacy of Hypericum perforatum against cisplatin-induced hepato-renal toxicity in mice with insights into the TXNIP/NLRP3 pathway

Salem,

Morsi,

El-Wakil

et al. 2023

J Appl Pharm Sci

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Hypericum perforatum (HP) has antioxidant and anti-inflammatory characteristics. Nevertheless, its antiinflammatory effects against hepato-renal injury have not been investigated. Therefore, this survey is designed to evaluate the prophylactic effect of HP extract against cisplatin-(CDDP-) induced hepato-renal toxicity in mice. Also, the active ingredients of HP were recognized. Hepato-renal toxicity was prompted by a single dose of CDDP (13 mg/kg, intraperitoneally). HP was tested at 50, 100, and 200 mg/kg/day for 10 days. Liver and kidney enzymes, oxidative stress, and inflammatory markers were examined, and histopathological examinations were performed. Total phenolic and flavonoid contents, besides 2,2-diphenyl-l-picrylhydrazyl radical scavenging activity, were assessed by identifying HP chemical compounds through high-performance liquid chromatography (HPLC) fingerprinting and gas chromatography-mass spectrometry. HP at 200 mg/kg improved hepatic and renal biochemical markers, reduced oxidative stress, and restored normal liver and kidney histology. Moreover, HP reduced inflammation by inhibiting TXNIP and NLRP3 tissue contents and cleaved caspase-1, interleukin-1β, and nuclear factor kappa-β expressions. The HPLC fingerprinting revealed high concentrations of ellagic acids, cinnamic acids, quercetin, and hesperidin, which may be responsible for alleviating hepato-renal damage. HP is an effective therapeutic agent against CDDP-induced hepato-renal toxicity and could be a realistic adjuvant therapy with CDDP for cancer treatment.

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“…Moreover, the species have been utilized as tea and dietary supplements (as an oil). The members of the genus Hypericum contain biologically active compounds, including hypericin, hyperforin and flavonoids [ 16 , 17 , 18 , 19 , 20 ]. Although many articles have been published on the biopharmaceutical properties of the Hypericum species [ 21 , 22 , 23 , 24 , 25 , 26 ], information on the chemical and biological properties is still lacking for most of them.…”

Section: Introductionmentioning

confidence: 99%

Novel Signposts on the Road from Natural Sources to Pharmaceutical Applications: A Combinative Approach between LC-DAD-MS and Offline LC-NMR for the Biochemical Characterization of Two Hypericum Species (H. montbretii and H. origanifolium)

Sut

Dall’Acqua

Zengin

et al. 2023

Plants

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The members of the genus Hypericum have great potential to develop functional uses in nutraceutical and pharmaceutical applications. With this in mind, we aimed to determine the chemical profiling and biological properties of different extracts (ethyl acetate, methanol and water) from two Hypericum species (H. montbretii and H. origanifolium). We combined two approaches (LC-DAD-MS and LC-NMR) to identify and quantify chemical compounds of the extracts. Antioxidant properties (free radical quenching, reducing power and metal chelating) and enzyme inhibitory effects (cholinesterase, tyrosinase, amylase and glucosidase) were determined as biological properties. The tested extracts were rich in caffeic acid derivatives and flavonoids, and among them, 3-caffeoyl quinic acid and myricetin-3-O-rhamnoside were found to be the main compounds. The total phenolic and flavonoid levels were determined to be 50.97–134.99 mg GAE/g and 9.87–82.63 mg RE/g, respectively. With the exception of metal chelating, the methanol and water extracts showed stronger antioxidant properties than the ethyl acetate extracts. However, different results were obtained for each enzyme inhibition assay, and in general, the ethyl acetate extracts present more enzyme-inhibiting properties than the water or methanol extracts. Results from chemical and biological analyses were combined using multivariate analysis, which allowed establishing relationships between composition and observed effects of the Hypericum extracts based on the extraction solvents. To gain more insights between chemical compounds and enzyme-inhibiting effects, we performed molecular docking analysis. We observed favorable interactions between certain compounds and the tested enzymes during our analysis, confirming the data obtained from the multivariate approach. In conclusion, the obtained results may shed light on the road from natural sources to functional applications, and the tested Hypericum species may be considered potential raw materials, with promising chemical constituents and biological activities.

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Ontogenetic changes in phenolic contents and volatile composition of Hypericum androsaemum and Hypericum xylosteifolium

Cited by 7 publications

References 79 publications

Active compounds and biological activities of Hypericum androsaemum L.: A review

Active compounds and biological activities of Hypericum androsaemum L.: A review

HPLC fingerprinting/GC-MS analysis, and efficacy of Hypericum perforatum against cisplatin-induced hepato-renal toxicity in mice with insights into the TXNIP/NLRP3 pathway

Novel Signposts on the Road from Natural Sources to Pharmaceutical Applications: A Combinative Approach between LC-DAD-MS and Offline LC-NMR for the Biochemical Characterization of Two Hypericum Species (H. montbretii and H. origanifolium)

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