Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary

Haddad, Samuel P.; Du, Bowen; Scott, William C.; Saari, Gavin N.; Breed, Christopher S.; Kelly, Martin H.; Broach, Linda; Chambliss, C. Kevin; Brooks, Bryan W.

doi:10.1016/j.marenvres.2017.03.006

Cited by 11 publications

(4 citation statements)

References 45 publications

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“…Bioaccumulation of pharmaceuticals in aquatic and terrestrial wildlife has received increasing studies in urban regions, though compared to freshwater, field data for accumulation of therapeutics in estuarine and marine systems are limited, particularly for bivalves. ,− Information on bioaccumulation of pharmaceuticals in estuarine and marine systems in Hong Kong and other developing regions in Asia are decidedly lacking. − Most reports on accumulation of pharmaceuticals by marine bivalves in Asia focus on antibiotics, which have been detected in mollusks from the Bohai Sea in China (e.g., erythromycin (1.6 μg/kg dry weight, dw) and other invertebrate species in Laizhou Bay, North China. , Accumulation of pharmaceuticals was also observed in Mytilus spp. caged for one year along the Irish coast, where trimethoprim was measured up to 9.2 μg/kg dw and carbamazepine was consistently measured at part per billion levels (<4 μg/kg dw) as dry weight .…”

Section: Resultsmentioning

confidence: 99%

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

Burket

Sapozhnikova

Zheng

et al. 2018

J. Agric. Food Chem.

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Aquaculture, which is growing 3-5 times faster than terrestrial agriculture, will play an important role to meet future global food production needs. However, over 80% of global sewage production is returned to the environment untreated or poorly treated. In developing nations, these nontraditional waters of diverse quality are being recycled for aquaculture, yet chemical residues are differentially studied. Here, we examined pharmaceuticals, pesticides, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and flame retardants in marine bivalves using isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) and low-pressure gas chromatography-tandem mass spectrometry (LP GC-MS/MS). Green-lipped mussels from the field and oysters from aquaculture net pens, which are harvested as food products, were collected adjacent to point source municipal wastewater and landfill leachate effluent discharges, respectively, in Hong Kong, the fourth most densely populated country in the world. Multiple classes of pharmaceutical, pesticides, PAHs, and phosphorus-based flame retardants were detected at low μg/kg levels. Acceptable servings per week indicated minimal risk for a number of chemicals; however, such calculations could not be performed for other contaminants of emerging concern. Future efforts are needed to better understand contaminant influences on marine bivalve populations and aquaculture product safety, particularly in rapidly urbanizing regions of developing countries with limited wastewater infrastructure.

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Section: Resultsmentioning

confidence: 99%

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

Burket

Sapozhnikova

Zheng

et al. 2018

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

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“…Bioaccumulation resulting in maternal transfer and direct effects on offspring ontogeny appears to be a less common phenomenon for CECs than reported for many legacy contaminants. However, PFOS has been known to bioaccumulate in aquatic organisms (Du et al 2009;Haddad et al 2017) and may lead to adverse outcome for first filial generation offspring of exposed parental organisms (Du et al 2009). Similarly, some pharmaceuticals have been reported to bioaccumulate in tissues with little knowledge of the long-term consequences (Zhao et al (2017)).…”

Section: Challenge 3: Duration Of Cec Exposure Within and Across Gene...mentioning

confidence: 99%

“…Similarly, Zhao et al (2017) reported bioconcentration for several pharmaceuticals to be highest in the liver and the brain and lower in muscle tissues. An understanding of pharmaceutical bioaccumulation across size classes of organisms displaying ontogenetic feeding shifts is lacking (Haddad et al 2017). This may be of concern when CECs are incorporated into the gamete through maternal transfer and impact the developing embryo through its nutrient source.…”

Section: Challenge 3: Duration Of Cec Exposure Within and Across Gene...mentioning

confidence: 99%

Critical review: Grand challenges in assessing the adverse effects of contaminants of emerging concern on aquatic food webs

Nilsen

Smalling

Ahrens

et al. 2018

Environmental Toxicology and Chemistry

187

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Much progress has been made in the past few decades in understanding the sources, transport, fate, and biological effects of contaminants of emerging concern (CECs) in aquatic ecosystems. Despite these advancements, significant obstacles still prevent comprehensive assessments of the environmental risks associated with the presence of CECs. Many of these obstacles center around the extrapolation of effects of single chemicals observed in the laboratory or effects found in individual organisms or species in the field to impacts of multiple stressors on aquatic food webs. In the present review, we identify 5 challenges that must be addressed to promote studies of CECs from singular exposure events to multispecies aquatic food web interactions. There needs to be: 1) more detailed information on the complexity of mixtures of CECs in the aquatic environment, 2) a greater understanding of the sublethal effects of CECs on a wide range of aquatic organisms, 3) an ascertaining of the biological consequences of variable duration CEC exposures within and across generations in aquatic species, 4) a linkage of multiple stressors with CEC exposure in aquatic systems, and 5) a documenting of the trophic consequences of CEC exposure across aquatic food webs. We examine the current literature to show how these challenges can be addressed to fill knowledge gaps. Environ Toxicol Chem 2019;38:46–60. © 2018 SETAC

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“…Contamination with PFOS in soil and water sources has been well documented throughout the world (Giesy and Kannan 2001;Ahrens and Bundschuh 2014;Wang et al 2017;DeWitt et al 2019). Compounding the problem of persistent, widespread contamination is that PFOS can bioaccumulate in individual organisms and biomagnify within the food chain (Martin et al 2004;Haddad et al 2017;Liu et al 2019). Studies have shown that exposure to PFOS may cause a myriad of adverse effects in both aquatic and terrestrial organisms, including humans.…”

Section: Introductionmentioning

confidence: 99%

Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion

Mylroie

Wilbanks

Kimble

et al. 2020

Environmental Toxicology and Chemistry

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Perfluorooctanesulfonic acid (PFOS) is a perfluorinated compound used in many industrial and consumer products. It has been linked to a broad range of adverse effects in several species, including zebrafish (Danio rerio). The zebrafish embryo is a widely used vertebrate model to elucidate potential adverse effects of chemicals because it is amenable to medium and high throughput. However, there is limited research on the full extent of the impact the chorion has on those effects. Results from the present study indicate that the presence of the chorion affected the timing and incidence of mortality as well as morphometric endpoints such as spinal curvature and swim bladder inflation in zebrafish embryos exposed to PFOS. Furthermore, removal of the chorion prior to exposure resulted in a lower threshold of sensitivity to PFOS for effects on transcriptional expression within the peroxisome proliferator–activated receptor (PPAR) nuclear signaling pathway. Perturbation of PPAR pathway gene expression can result in disruption of metabolic signaling and regulation, which can adversely affect development, energy availability, and survival. It can be concluded that removal of the chorion has significant effects on the timing and incidence of impacts associated with PFOS exposure, and more research is warranted to fully elucidate the protective role of the chorion and the critical timing of these events. Environ Toxicol Chem 2021;40:780–791. Published 2020. This article is a US Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary

Cited by 11 publications

References 45 publications

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

Critical review: Grand challenges in assessing the adverse effects of contaminants of emerging concern on aquatic food webs

Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion

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