Ontogenetic role of angiontensin-converting enzyme in rats: Thirst and sodium appetite evaluation

Mecawi, André Souza; Araujo, Iracema; Rocha, Fábio Fagundes da; Coimbra, Terezila Machado; Antunes‐Rodrigues, José; Reis, L. C.

doi:10.1016/j.physbeh.2009.10.018

Cited by 12 publications

(9 citation statements)

References 36 publications

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“…The effects of Ang II are mediated by the type 1 and 2 Ang receptors (AT 1 and AT 2 , respectively) (6). The AT 1 receptors are responsible for the main effects of Ang II in adults, such as aldosterone secretion and vascular contraction, as well as thirst and sodium appetite responses (6)(7)(8)(9)12). Our group has demonstrated the importance of brain AT 1 receptors in sodium appetite induced by i.c.v.…”

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confidence: 99%

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The Role of Angiotensin II on Sodium Appetite After a Low‐Sodium Diet

Mecawi

Vilhena‐Franco

Fonseca

et al. 2013

J Neuroendocrinology

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The present study aimed to investigate the role of angiotensin II (Ang II) on sodium appetite in rats subjected to a normal or a low-sodium diet (1% or > 0.1% NaCl) for 4 days. During sodium restriction, a reduction in water intake, urinary volume and sodium excretion was observed. After a low-sodium diet, we observed decreased plasma protein concentrations and haematocrit associated with a slight reduction in arterial pressure, without any significant changes in heart rate, natraemia, corticotrophin-releasing hormone mRNA expression in the paraventricular nucleus and corticosterone levels. After providing hypertonic saline, there was an increase in saline intake followed by a small increase in water intake, resulting in an enhanced saline intake ratio and the recovery of arterial pressure. Sodium deprivation increased plasma but not brain Ang I and II concentrations. A low-sodium diet increased kidney renin and liver angiotensinogen mRNA levels but not lung angiotensin-converting enzyme mRNA expression. Moreover, Ang II type 1a receptor mRNA expression was increased in the subfornical organ and the dorsal raphe nucleus and decreased in the medial preoptic nuclei, without changes in the paraventricular nucleus and the nucleus of solitary tract after a low-sodium diet. Blockade of AT(1) receptors or brain Ang II synthesis led to a reduction in sodium intake after a low-sodium diet. Intracerebroventricular injection of Ang II led to a similar increase in sodium and water intake in the control and low-sodium diet groups. In conclusion, the results of the present study suggest that Ang II is involved in the increased sodium appetite after a low-sodium diet.

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confidence: 99%

“…Angiotensin II (Ang II) is directly involved in the control of renal sodium excretion and in the neural control of sodium appetite, thus regulating the body's sodium balance (1)(2)(3)(4)(6)(7)(8)(9). The precursor molecule of the renin-angiotensin system (RAS) is a-globulin angiotensinogen (Agt).…”

mentioning

confidence: 99%

The Role of Angiotensin II on Sodium Appetite After a Low‐Sodium Diet

Mecawi

Vilhena‐Franco

Fonseca

et al. 2013

J Neuroendocrinology

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“…The baby rats of low-salt mothers conceivably have dysfunction of osmolality homeostasis. In fact, it is well known that angiotensin II (ATII) in the central nervous system enhances water appetite [11]- [13]. Moreover, we have reported that angiotensinogen gene polymorphism (rs 699) is associated with changes of food behavior in young, non-obese female subjects [14].…”

Section: Discussionmentioning

confidence: 99%

Low Salt Diet in Pregnant Mothers Is Associated with Enhanced Salt Appetite in Their Offspring of Dahl Salt-Sensitive Rats

Hara¹,

Chow²,

Du³

et al. 2014

FNS

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Objectives: We investigated an influence of salt intake during gestation or lactation in salt preference of weaning Dahl salt sensitive (Dahl S) strain. Material and Methods: Nine-week-old female Dahl S rats, after mated with the male, were divided into 1) high-salt group fed a 4% NaCl diet (high-salt mother) or 2) low-salt group fed a 0.3% NaCl diet (low-salt mother) during gestation or lactation periods. Using 0.4%, 0.6% and 0.8% (w/v) saline solutions, we assessed salt preference in their offspring after weaning. Systolic blood pressure (SBP) was determined by tail cuff method. Results: Both the male and female offspring from low-salt mothers during gestation consumed equal amounts of any saline solution. However, the amount of each saline solution was higher in the offspring of low-salt mothers than those of high-salt mothers. This resulted in a significant increase of salt intake in both the male and female offspring of low-salt mothers compared with those of high-salt mothers. In contrast, both the male and female offspring from low-mothers during lactation rather preferred the lower concentration of saline solution, and this resulted in less salt intake in the offspring of low-salt mothers than those of high-salt mothers. Conclusions: We demonstrated that low salt diet in pregnant mothers increased salt intake of their offspring. The offspring of mothers fed a low salt diet during lactation had less salt than those of high-salt mothers. The influence of salt intake of mothers in their offspring varies along with the growth stage of their babies.

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“…In very young, normal female subjects, the consumption of total lipids, cholesterol, and unsaturated free fatty acids is higher in those with the MM/MT genotype of AGTMet235 [ 48 ]. In this context, some studies have been performed to postulate the role of intracerebral angiotensin II in water and salt drinking, and it is found that angiotensin II infusion in the cerebral fluid enhances behavior of drinking water and salt-appetite [ 49 – 51 ]. Salt-restriction evokes activity of the renin angiotensin system, and its upregulation due to salt-restriction during fetal growth might be associated with an increased salt-appetite.…”

Section: Introductionmentioning

confidence: 99%

Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood

et al. 2016

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Recent studies reported the critical role of the intrauterine environment of a fetus in growth or the development of disease in adulthood. In this article we discussed the implications of salt restriction in growth of a fetus and the development of growth-related disease in adulthood. Salt restriction causes retardation of fatal growth or intrauterine death thereby leading to low birth weight or decreased birth rate. Such retardation of growth along with the upregulation of the renin angiotensin system due to salt restriction results in the underdevelopment of cardiovascular organs or decreases the number of the nephron in the kidney and is responsible for onset of hypertension in adulthood. In addition, gestational salt restriction is associated with salt craving after weaning. Moreover, salt restriction is associated with a decrease in insulin sensitivity. A series of alterations in metabolism due to salt restriction are probably mediated by the upregulation of the renin angiotensin system and an epigenetic mechanism including proinflammatory substances or histone methylation. Part of the metabolic disease in adulthood may be programmed through such epigenetic changes. The modification of gene in a fetus may be switched on through environment factors or life style after birth. The benefits of salt restriction have been assumed thus far; however, more precise investigation is required of its influence on the health of fetuses and the onset of various diseases in adulthood.

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Ontogenetic role of angiontensin-converting enzyme in rats: Thirst and sodium appetite evaluation

Cited by 12 publications

References 36 publications

The Role of Angiotensin II on Sodium Appetite After a Low‐Sodium Diet

The Role of Angiotensin II on Sodium Appetite After a Low‐Sodium Diet

Low Salt Diet in Pregnant Mothers Is Associated with Enhanced Salt Appetite in Their Offspring of Dahl Salt-Sensitive Rats

Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood

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