Ontogenic aspects of cisplatin-induced nephrotoxicity in rats

Ali, Badreldin H.; Al-Moundhri, Mansour; Tageldin, Mohammed H.; Husseini, I.S. Al; Mansour, Mohmed A.; Nemmar, Abderrahim; Tanira, M. O. M.

doi:10.1016/j.fct.2008.07.030

Cited by 35 publications

(35 citation statements)

References 25 publications

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“…Dilation of tubules and various other necrotic changes characterized by karyorvhexis and karyolysis at the nuclei of affected cells of L.rohita exposed to hexachloro-cyclohexane have been reported 26 . Similar kind of tubular necrosis, desquamation and vacuolization of tubular epithelial cells in kidney of fish exposed to lindane have been noticed 27 . Fish exposed to arsenic showed similar results 28 .…”

Section: Histopathological Studiesmentioning

confidence: 64%

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2016

IJPSR

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The present study was aimed to assess the reno-protective impact of aqueous extract of root of Withania somnifera (WSR) commonly known as Ashwagandha against organochlorine induced renal toxicity in fish Clarias batrachus (Linn.).Fishes were exposed to 4ppb concentration of commercial brand Endocel, an organochlorine pesticide for one week and two week to prepare the toxic model. These toxic groups of fishes were further treated with aqueous root extract of Withania somnifera (WSR)@100 mg /kg body wt for four weeks. After schedule exposure, blood serum was extracted and analyzed for total protein (TP) content. Renal tissues were processed for light microscopy (LM) and transmission electron microscopy (TEM). Endocel lowered TP at almost every exposure level. At LM level WSR extract treatment showed restoration of normal luminal characteristics of PCT & DCT and renal corpuscles but it failed to minimize abortive glomerulus, necrotic renal tubules with hypertrophied area, haemorrhagical clots & chronic venous congestion. At TEM level, WSR extract showed maximum retrieval in the cytoarchitecture of cuboidal epithelial cells of renal tubules and renal corpuscles. Concomitant treatment of endocel and WSR showed a very little sign of anomalies in renal tissues. A non-significant change was marked in control group when treated only with WSR extract. The serum level of TP showed a significant decline in organochlorine treated fish when compared with control. They showed a significant recovery after WSR treatment for four weeks. Concomitant treatment of endocel and WSR to the experimental group showed non-significant (at P<0.05) changes in TP. The WSR treatment alone to control group didn"t show any significant correction in lowered TP. A perfect correlation between biochemical and histopathological finding signifies the excellent restorative power of WSR extract against organochlorine induced renal toxicity in fish.

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Section: Histopathological Studiesmentioning

confidence: 64%

Untitled

2016

IJPSR

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“…4, the body weight on day 7 significantly increased compared to that on day 0 in 4-and 6-week-old rats, whereas it signifi cantly decreased in 8-and 24-week-old rats. As discussed by Ali et al, 17 the reduction in body weight following cisplatin administration in older rats may be due to injured renal tubules and subsequent loss of the tubular cells to reabsorb water, leading to dehydration and loss of body weight.…”

Section: Discussionmentioning

confidence: 96%

Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography

et al. 2010

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“…Acute renal failure has been induced by ischemia followed by reperfusion technique as described in the method of Ali et al (2008). Briefly, single injection of cisplatin (6 mg/kg) was administered intraperitoneally (i.p.)…”

Section: Induction Of Arf By Cisplatinmentioning

confidence: 99%

Therapeutic potential of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion injury-induced acute renal failure in rats

Muthuraman

Sood

Ramesh³

et al. 2012

Naunyn-Schmiedeberg's Arch Pharmacol

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This study was designed to investigate the role of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion (I/R)-induced acute renal failure in rats. Acute renal failure was induced in rats by administration of a single dose of cisplatin (CP) (6 mg/kg, intraperitoneally on day 6) and occlusion of the left renal artery for 45 min (I) and opened for the next 24 h (R). The drug samples of 7,8-dimethoxycoumarin (DMC, 50, 75, and 100 mg/kg) and cyclosporin A (50 μM/kg) were administered orally for six consecutive days. Administration of a single dose of cisplatin and I/R event has significantly raised blood urea nitrogen and creatinine, N-acetyl beta-D: -glucosaminidase, and thiobarbituric acid reactive substances but decreased FrNa, creatinine clearance, reduced glutathione (GSH), mitochondrial cytochrome c oxidase, and adenosine triphosphate levels. Further, pretreatment of DMC (50, 75, and 100 mg/kg, p.o., for six consecutive days) has ameliorated the CP- and I/R-induced biochemical and histopathological changes in a dose-dependent manner. Furthermore, 75 and 100 mg/kg of 7,8-dimethoxycoumarin has shown to possess the significant renoprotective effect similar to that of the cyclosporin A-treated group which served as positive control. Based on the results of the present study, it has been concluded that 7,8-dimethoxycoumarin protects the kidney against the CP and I/R injury via antioxidant, anti-inflammatory, and inactivation of mitochondrial permeability transition pore opening.

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Ontogenic aspects of cisplatin-induced nephrotoxicity in rats

Cited by 35 publications

References 25 publications

Untitled

Untitled

Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography

Therapeutic potential of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion injury-induced acute renal failure in rats

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