Ontogeny of calretinin in chick dorsal root ganglion neurons

Király, Elisabeth; Celio, Marco R.

doi:10.1016/0165-3806(92)90114-c

Cited by 20 publications

(10 citation statements)

References 16 publications

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“…The radically different developmental pattern of CaR shown in this study compared to that of CaB and PV, however, suggests that each protein plays a different role in cortical development (Endo et a]., 1985;Enderlin et al, 1987;Stichel et al, 1987;Braun et al, 1988;Hendrickson et al, 1991). A possible linkage between the expression of CaR and functional maturation of neurons, or synaptogenesis of individual cell types in retina has been proposed (Ellis et al, 1991;Kiraly and Celio, 1992). Although the distribution of GABA cell bodies is stable by late gestation (Yan et al, 19921, that of cell bodies containing CaR, CaB, or PV continues to change well into infancy.…”

Section: What Is the Functional Role Of Calretinin During Development?mentioning

confidence: 71%

Developmental changes in calretinin expression in GABAergic and nonGABAergic neurons in monkey striate cortex

Yan

Brederode

Hendrickson

1995

J of Comparative Neurology

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The development of the calcium-binding protein calretinin (CaR) and its co-localization with GABA was studied in the striate cortex of Macaca monkeys from fetal day (Fd) 45 to adult. At Fd45, early neurons resembling Cajal-Retzius cells are stained in the marginal zone (MZ). At Fd55 the MZ is filled with CaR+ Cajal-Retzius cells and their processes, and scattered CaR+ cells are also found in deep cortical plate (CP), intermediate zone (IZ), and subventricular zone (SVZ). At Fd66, a band of CaR+ fibers appears in the IZ, corresponding to the location of the geniculocortical axons. This fiber band labels heavily until Fd130 but then ceases to be immunoreactive by postnatal (P) 16 weeks. At Fd85-101, the number of CaR+ cells in the CP, SVZ, and ventricular zone (VZ) reaches its highest cell density. After Fd130, CaR+ cells are concentrated in layer II and upper layer III, and this distribution changes little into adulthood. After mid-gestation, there is a progressive loss of CaR+ cell bodies and processes in the MZ, and these are rare in the adult cortex. Just before birth, a weakly stained CaR+ cell band appears in layer IVA at the border between layer IVA and IVB, but this band disappears immediately after birth. Another CaR+ cell band appears transiently in upper layer V just below the border with layers IV at P6 months. These results suggest that CaR is expressed early in fetal development in the cell populations that are immunoreactive for CaR in the adult. However, developmental events related to cortical maturation during late prenatal and early postnatal stages result in transient expression of CaR in neurons that are not immunoreactive for CaR in the adult. CaR-immunoreactivity is colocalized with GABA in almost all CaR+ cells with the exception of Cajal-Retzius cells in the MZ and some large cells observed at Fd70-101 in the VZ. The band of CaR+ fibers in the IZ is GABA-. At Fd90, almost all (> 96%) CaR+ cells are GABA+ in the CP and the first developed layers V/VI. This percentage declines later, so that on average 80% of CaR+ cells are GABA+ in adult cortex. At Fd135, 53% of GABA+ neurons located in layers II/III are CaR+; this percentage declines to 37% in the adult. These double-label patterns suggest that early in fetal development the majority of GABA+ cells stain for CaR and that expression of CaR may be related to the migration of these neurons into the cortical plate. Once they attain their final position in the cortex many GABA+ cells loose CaR-immunoreactivity, so that in postnatal life only a minority of GABA+ neurons contain this calcium-binding protein.

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Section: What Is the Functional Role Of Calretinin During Development?mentioning

confidence: 71%

Developmental changes in calretinin expression in GABAergic and nonGABAergic neurons in monkey striate cortex

Yan

Brederode

Hendrickson

1995

J of Comparative Neurology

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“…In contrast, CR immunoreactivity is restricted to a subpopulation of large-sized neurons (Kiraly and Celio, 1992), most of which coexpress CB immunoreactivity (Duc er a l . , 1993b).…”

Section: Introductionmentioning

confidence: 93%

Innervation of Putative Rapidly Adapting Mechanoreceptors by Calbindin‐ and Calretinin‐immunoreactive Primary Sensory Neurons in the Rat

Duc

Barakat‐Walter

Droz

1994

Eur J of Neuroscience

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Calbindin and calretinin are two homologous calcium-binding proteins that are expressed by subpopulations of primary sensory neurons. In the present work, we have studied the distribution of the neurons expressing calbindin and calretinin in dorsal root ganglia of the rat and their peripheral projections. Calbindin and calretinin immunoreactivities were expressed by subpopulations of large- and small-sized primary sensory neurons and colocalized in a majority of large-sized ones. The axons emerging from calbindin- or calretinin-immunoreactive neurons innervated muscle spindles, Pacini corpuscles and subepidermal lamellar corpuscles in the glabrous skin, formed palisades of lanceolate endings around hairs and vibrissae, and gave rise to intraepidermal nerve endings in the digital skin. Since most of these afferents are considered as rapidly adapting mechanoreceptors, it is concluded that calbindin- or calretinin-expressing neurons innervate particular mechanoreceptors that display physiological characteristics of rapid adaptation to stimuli.

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“…CR contains six potential calcium binding domains, five of which are thought to be active in binding calcium (Parmentier, 1989). This protein is expressed in a subpopulation of neurons of the CNS and the PNS (Rogers, 1989;Baimbridge et al, 1992;Kiraly and Celio, 1992;Resibois and Rogers, 1992;Andressen et al, 1993;Duc et al, 1993Duc et al, , 1994Ambrus et al, 1998) and is particularly abundant in neurons associated with the sensory pathway (Ren et al, 1993;Ren and Ruda, 1994). To date, the exact function of CR in the nervous system remains to be discovered.…”

Section: Indexing Terms: Hypothyroidism; Sensory Pathways; Calcium-bimentioning

confidence: 97%

Differential effect of thyroid hormone deficiency on the growth of calretinin-expressing neurons in rat spinal cord and dorsal root ganglia

et al. 2000

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The development of spinal cord or dorsal root ganglia neurons expressing calretinin (CR) was studied in thyroid hormone-deficient rats. Immunocytochemical and morphometric analyses showed that the hypothyroidism induced a significant decrease in the number and size of immunoreactive neurons in the spinal cord, as well as stunted growth and arborization of the axons and dendrites. These alterations were observed at different embryonic ages and persisted during the whole postnatal life. In adult hypothyroid rats, the mean number of CR-positive neurons per spinal cord section (31.2 +/- 2.3 in laminae I and II and 30.5 +/- 5.5 in laminae III-X) was significantly decreased (P < 0.001 and P = 0.024, respectively) compared with adult normal rats (68.7 +/- 8.9 and 50.0 +/- 11.0, respectively). In the peripheral nervous system, hypothyroidism altered the growth of sensory neurons expressing CR protein mainly during embryonic life. In comparison with normal rats, hypothyroid embryonic animals showed not only reduced cell size but also a significantly decreased percentage of CR-positive neurons (6.6 +/- 0. 9% in normal, 2.1 +/- 0.3% in hypothyroid rats, P < 0.001). In contrast, although the size of neurons was reduced in hypothyroid young and adult rats, there was no reduction in the percentage of CR-positive neurons. These results showed that thyroid hormone deficiency altered differentially the development of neurons expressing CR protein in the central and peripheral nervous systems. This suggests that central and peripheral neurons are heterogeneous in their sensitivity to thyroid hormone.

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Ontogeny of calretinin in chick dorsal root ganglion neurons

Cited by 20 publications

References 16 publications

Developmental changes in calretinin expression in GABAergic and nonGABAergic neurons in monkey striate cortex

Developmental changes in calretinin expression in GABAergic and nonGABAergic neurons in monkey striate cortex

Innervation of Putative Rapidly Adapting Mechanoreceptors by Calbindin‐ and Calretinin‐immunoreactive Primary Sensory Neurons in the Rat

Differential effect of thyroid hormone deficiency on the growth of calretinin-expressing neurons in rat spinal cord and dorsal root ganglia

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