Ontogeny of fetal movements in the guinea pig

Kan, Colette M van; Vries, J.I.P. de; Lüchinger, Annemarie B.; Mulder, E.J.H.; Taverne, M.A.M.

doi:10.1016/j.physbeh.2009.06.011

Cited by 20 publications

(23 citation statements)

References 18 publications

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“…Van Kan et al (2009) evaluated the integrity and development of the nervous system in young animals through the evaluation of fetal movement patterns and found a striking similarity in patterns of humans and guinea pigs, suggesting this animal as a promising model for evaluating the effects of physical, chemical and biological external agents in the nervous system during fetal development.…”

Section: Discussionmentioning

confidence: 99%

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

et al. 2016

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This study describes the development of the central nervous system in guinea pigs from 12th day post conception (dpc) until birth. Totally, 41 embryos and fetuses were analyzed macroscopically and by means of light and electron microscopy. The neural tube closure was observed at day 14 and the development of the spinal cord and differentiation of the primitive central nervous system vesicles was on 20th dpc. Histologically, undifferentiated brain tissue was observed as a mass of mesenchymal tissue between 18th and 20th dpc, and at 25th dpc the tissue within the medullary canal had higher density. On day 30 the brain tissue was differentiated on day 30 and the spinal cord filling throughout the spinal canal, period from which it was possible to observe cerebral and cerebellar stratums. At day 45 intumescences were visualized and cerebral hemispheres were divided, with a clear division between white and gray matter in brain and cerebellum. Median sulcus of the dorsal spinal cord and the cauda equina were only evident on day 50. There were no significant structural differences in fetuses of 50 and 60 dpc, and animals at term were all lissencephalic. In conclusion, morphological studies of the nervous system in guinea pig can provide important information for clinical studies in humans, due to its high degree of neurological maturity in relation to its short gestation period, what can provide a good tool for neurological studies.

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Section: Discussionmentioning

confidence: 99%

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

et al. 2016

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“…For example, the use of ultrasound technology as a non-invasive means to observe behavioral development longitudinally in the fetus often requires both restraint of the pregnant female, and removal of abdominal fur. [6, 7, 25] Restraint is a known stressor for rodents, and in fact is often used as a reliable method to induce stress. [26] Use of such methods with pregnant animals is doubly problematic, because elevated stress can significantly alter both behavior and hormonal development in the fetus.…”

Section: Introductionmentioning

confidence: 99%

An ecologically relevant guinea pig model of fetal behavior

Bellinger

Lucas

2015

Behavioural Brain Research

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The laboratory guinea pig, Cavia porcellus, shares with humans many similarities during pregnancy and prenatal development, including precocial offspring and social dependence. These similarities suggest the guinea pig as a promising model of fetal behavioral development as well. Using innovative methods of behavioral acclimation, fetal offspring of female IAF hairless guinea pigs time mated to NIH multi-colored Hartley males were observed longitudinally without restraint using noninvasive ultrasound at weekly intervals across the 10 week gestation. To insure that the ultrasound procedure did not cause significant stress, salivary cortisol was collected both before and after each observation. Measures of fetal spontaneous movement and behavioral state were quantified from video recordings from week 3 through the last week before birth. Results from prenatal quantification of Interlimb Movement Synchrony and state organization reveal guinea pig fetal development to be strikingly similar to that previously reported for other rodents and preterm human infants. Salivary cortisol readings taken before and after sonography did not differ at any observation time point. These results suggest this model holds translational promise for studying the prenatal mechanisms of neurobehavioral development, including those that may result from adverse events. Because the guinea pig is a highly social mammal with a wide range of socially oriented vocalizations, this model may also have utility for studying the prenatal origins and trajectories of developmental disabilities with social-emotional components, such as autism.

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“…Unlike other laboratorial rodents, guinea pigs have an extended estrous cycle of 16 to 18 d (Joshi et al, 1973;Trewin et al, 1998), cannot be superovulated by follicle-stimulating hormone (FSH) or equine chorionic gonadotropin (eCG) but rather with inhibin immunizations (Shi et al, 2000a), and have a full gestation of 68 d and a small litter size of 3.8 on average (van Kan et al, 2009). Owing to these special biological characteristics, the process of follicular atresia in guinea pigs also has unique features.…”

Section: Introductionmentioning

confidence: 99%

Morphologic observation and classification criteria of atretic follicles in guinea pigs

Wang

Liu

Tian

et al. 2010

J. Zhejiang Univ. Sci. B

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Abstract:There is a lack of appropriate classification criteria for the determination of atretic follicles in guinea pigs. In the present study, new criteria were established based on the latest morphologic criteria for cell death proposed by the Nomenclature Committee on Cell Death (NCCD) in 2009. Ovaries of guinea pigs were sampled on different stages of estrous cycle, and the morphologic observations of atretic follicles were investigated in serial sections. The results showed that the process of follicular atresia could be classified into four continuous stages: (1) the granulosa layer became loose, and some apoptotic bodies began to appear; (2) the granulosa cells were massively eliminated; (3) the theca interna cells differentiated; and (4) the residual follicular cells degenerated. In addition, the examination revealed that these morphologic criteria were accurate and feasible. In conclusion, this study provides new criteria for the classification of atretic follicles in guinea pigs, and this knowledge can inform future research in the area.

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Ontogeny of fetal movements in the guinea pig

Cited by 20 publications

References 18 publications

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

An ecologically relevant guinea pig model of fetal behavior

Morphologic observation and classification criteria of atretic follicles in guinea pigs

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