Ontogeny of ionotropic glutamate receptor subunit expression in the rat hippocampus

Ritter, L; Vázquez, Delia M.; Meador‐Woodruff, James H.

doi:10.1016/s0165-3806(02)00572-2

Cited by 120 publications

(97 citation statements)

References 32 publications

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“…Throughout postnatal development, expression of NR2A mRNA and protein increases to a peak in all brain areas at around the third postnatal week and then a slight reduction in the adult rodent brain , Sheng et al, 1994, Zhong et al, 1995, Guilarte and McGlothan, 1998, Ritter et al, 2002. There is a pronounced increase in NR2B expression, particularly protein levels, during the first week in most brain regions , Ritter et al, 2002.…”

Section: Nmda Receptors: Structure Function and Distributionmentioning

confidence: 99%

“…There is a pronounced increase in NR2B expression, particularly protein levels, during the first week in most brain regions , Ritter et al, 2002. However there appears to be conflicting results of NR2B expression from this point until adulthood with some studies showing cortical NR2B expression remains constant from early development to adulthood (Sheng et al, 1994, Zhong et al, 1995, Portera-Cailliau et al, 1996 while others have found a decrease in NR2B levels, between PN21 and adulthood ).…”

Section: Nmda Receptors: Structure Function and Distributionmentioning

confidence: 99%

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Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia

Geddes

Huang

Newell

2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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. (2011) Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin 1 and their role in schizophrenia, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 4, 1 June 2011 pp. 896-904. Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin 1 and their role in schizophrenia AbstractSchizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the N-methyl-D-aspartate receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and functional subunits of the NMDAR and are developmentally and spatially regulated. Altered NR2 gene and protein expression has been found in human post-mortem schizophrenia brain tissue together with changes in NRG1 and its receptor ErbB4. The NR2 subunits and ErbB4 share a common anchoring domain on the postsynaptic density and therefore a disruption to either of these molecules may influence the functioning of the other. It has been shown that NRG1 signalling can affect NMDAR levels and function, particularly phosphorylation of the NR2 subunits. However little is known about the possible effects of NMDAR dysfunction on NRG1 signalling, which is important with regards to schizophrenia aetiology as numerous risk factors for the disorder can alter NMDAR functioning during early brain development. This review focuses on the role of the NMDA receptor subunits and NRG1 signalling in schizophrenia and proposes a mechanism by which a disruption to the NMDAR, particularly via altering the balance of NR2 subunits during early development, could influence NRG1 signalling. Tables : 1 2 Abstract Schizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the Nmethyl-D-aspartate receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and functional subunits of the NMDAR and are developmentally and spatially regulated. Altered NR2 gene and protein expression has been found in human post-mortem schizophrenia brain tissue together with changes in NRG1 and its receptor ErbB4. The NR2 subunits and ErbB4 share a common anchoring domain on the postsynaptic density and therefore a disruption to either of these molecules may influence the functioning of the other. It has been shown that NRG1 signalling can affect NMDAR levels and function, particularly phosphorylation of the NR2 subunits. However not much is known about the possible effects of NMDAR dysfunction on NRG1 signalling, which is important with regards to schizophrenia aetiology as numerous risk factors for the disorder can alter NMDAR functioning during early brain development. This review focuses on the role of the NMDA receptor subunits and NRG1 signalling in schizophrenia and proposes a mechanism by which a disruption to the NMDAR, particularly via the altering...

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Section: Nmda Receptors: Structure Function and Distributionmentioning

confidence: 99%

Section: Nmda Receptors: Structure Function and Distributionmentioning

confidence: 99%

Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia

Geddes

Huang

Newell

2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…The rationale behind was that, during postnatal development, GluK1 receptors are highly expressed in the hippocampus (Bettler et al, 1990;Bahn et al, 1994;Ritter et al, 2002) and previous work from immature CA3 pyramidal cells demonstrated the involvement of GluK1 in modulation of spontaneous, network-driven giant depolarizing potentials (GDPs) , which are highly expressed in the CA3 area (Ben-Ari et al, 2007). Like DNQX, UBP 302 (10 M) caused a significant increase in amplitude of GPSCs (Fig.…”

Section: Resultsmentioning

confidence: 98%

In the Developing Rat Hippocampus, Endogenous Activation of Presynaptic Kainate Receptors Reduces GABA Release from Mossy Fiber Terminals

Caiati¹,

Sivakumaran²,

Cherubini³

2010

J. Neurosci.

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“…Levels of DA can become concentrated in the amniotic fluid and both fetuses exposed to DA in utero and pups exposed via breast milk are substantially more sensitive to this toxin than are rodents exposed in adulthood [28][29][30][31]. After crossing the blood-brain barrier [32], DA binds to glutamate receptors expressed in several regions of the developing brain, including the cortical and limbic areas that regulate social behavior [34,35].…”

Section: Toxicity Of Domoic Acidmentioning

confidence: 99%

What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine

Lahvis

2017

EPMA Journal

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Autism spectrum disorder (ASD) shares many biological and behavioral similarities with the deleterious effects of domoic acid (DA) exposure. DA is produced by marine algae and most commonly by species of Pseudo-nitzschia. Humans and marine mammals can be exposed to DA when they consume whole fish or shellfish. The mammalian fetus is highly sensitive to the deleterious effects of DA exposure. Both ASD and exposures to toxic levels of DA feature repetitive behaviors, challenges with social interaction, and seizures. They can also share a commonality in brain anatomy and function, particularly the balance between excitatory and inhibitory mechanisms. The current article is relevant to predictive, preventive, and personalized medicine for three reasons. First, shellfish consumption may be a risk factor for ASD and the regulatory limit for DA should be adjusted to prevent this possibility. Human contributions to increased algal production of DA in coastal waters should be identified and reduced. Second, evaluations of sentinel species wild and free-roaming in the environment, though typically outside the purview of biomedical research, should be much more fully employed to gain insights to risk factors for human disease. To better identify and prevent disease, biomedical researchers shouldstudy wildpopulations.Third, studies of DA exposure highlight the possibility that glutamate additives to processed foods may also have deleterious impacts on human brain development and behavior.Keywords Domoic acid . Autism spectrum disorder . Glutamate . Behavior . Anatomy . Brain . Development . Predictive diagnosis . Targeted prevention . Population screening Autism and its prevalenceAutism spectrum disorder (ASD) is often diagnosed early in childhood and features deficits in social interaction and communication and includes repetitive behaviors and circumscribed interests [1,2]. The prevalence of autism is more common among boys than girls [3] and has increased substantially over the past 20 years [3,4]. ASD is the most highly heritable developmental disability yet researchers have identified only a few genetic susceptibility factors [5][6][7][8][9][10] that can account for a small fraction of the diagnosed population [10].

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Ontogeny of ionotropic glutamate receptor subunit expression in the rat hippocampus

Cited by 120 publications

References 32 publications

Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia

Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia

In the Developing Rat Hippocampus, Endogenous Activation of Presynaptic Kainate Receptors Reduces GABA Release from Mossy Fiber Terminals

What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine

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