2001
DOI: 10.1016/s0165-3806(01)00126-2
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Ontogeny of ionotropic glutamate receptor expression in human fetal brain

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Cited by 73 publications
(43 citation statements)
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“…A similar pattern of NR2 mRNA and protein expression has been observed in a study of the human foetal brain, where NR2B is the predominant subunit expressed in all of the cortical layers as early as gestational week 8 with transient increases at week 11, 13 and 19 (Ritter et al, 2001). Moreover, there is a decline in NR2B mRNA in the human hippocampus from its peak expression during the neonatal stage of life to adulthood, whereas NR2A mRNA expression appears to remain consistent throughout the life stages .…”
Section: Nmda Receptors: Structure Function and Distributionsupporting
confidence: 79%
“…A similar pattern of NR2 mRNA and protein expression has been observed in a study of the human foetal brain, where NR2B is the predominant subunit expressed in all of the cortical layers as early as gestational week 8 with transient increases at week 11, 13 and 19 (Ritter et al, 2001). Moreover, there is a decline in NR2B mRNA in the human hippocampus from its peak expression during the neonatal stage of life to adulthood, whereas NR2A mRNA expression appears to remain consistent throughout the life stages .…”
Section: Nmda Receptors: Structure Function and Distributionsupporting
confidence: 79%
“…During the embryonic period, between E13 and E17, coinciding with the onset of an intense phase of neurogenesis in the cerebral cortex, relatively high levels of glutamate and aspartate were detected (table 1). Glutamate, considered as the most important excitatory neurotransmitter in the CNS, has a fundamental role in early cortical development through the activation of its receptors, both ionotropic as well as metabotropic [32,45,46]. In particular, N-methyl-D-aspartate receptors contribute to the modulation of calcium signals useful for a variety of developmental functions, such as neurogenesis progression, neuronal differentiation, dendritic arbor development and synaptogenesis [23,24,32,47].…”
Section: Discussionmentioning
confidence: 99%
“…To date, there are no studies using those techniques to examine AMPA or NMDA expression during postnatal development of human visual cortex. Both NMDA and AMPA receptors are expressed prenatally in the developing human cortex with high levels of both NR1 and NR2B (Ritter, Unis, & Meador-Woodruff, 2001); however, that study provided no quantification of laminar changes and did not analyze visual cortex. In animal models, there are postnatal changes in the laminar distributions of both AMPA and NMDA receptors.…”
Section: Consideration Of Laminar Developmentmentioning
confidence: 99%