Mucosal Immunology 2015
DOI: 10.1016/b978-0-12-415847-4.00011-2
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Ontogeny of Mucosal Immunity and Aging

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Cited by 10 publications
(8 citation statements)
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References 218 publications
(329 reference statements)
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“…African Blacks and African Americans are infected with EBV early in childhood, after the protective effect of maternal IgG anti-EBV antibodies acquired passively through placental transport has waned (49,50,(87)(88)(89). Naturally delayed maturation of the IgA system in early childhood manifests as absent or low levels of IgA in sera and secretions and low numbers of IgA-producing cells in tissues (54)(55)(56)(57)(58). In this setting, the possibility that EBV will infect such cells is greatly diminished.…”
Section: Discussionmentioning
confidence: 99%
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“…African Blacks and African Americans are infected with EBV early in childhood, after the protective effect of maternal IgG anti-EBV antibodies acquired passively through placental transport has waned (49,50,(87)(88)(89). Naturally delayed maturation of the IgA system in early childhood manifests as absent or low levels of IgA in sera and secretions and low numbers of IgA-producing cells in tissues (54)(55)(56)(57)(58). In this setting, the possibility that EBV will infect such cells is greatly diminished.…”
Section: Discussionmentioning
confidence: 99%
“…EBV infects most African Black and African American children by age 1-2 years (49)(50)(51)(52)(53). At this age, the entire IgA system is naturally deficient, as evidenced by the virtual absence or low levels of serum IgA and paucity of IgA-producing cells in various tissues (54)(55)(56)(57)(58). As a marker of IgA system maturation, serum IgA levels reach adult levels in puberty (54,57).…”
Section: Introductionmentioning
confidence: 99%
“…Possible causes could be related to minor modifications in the assay protocol, which included using lower antibody (1 mg/L versus 10 mg/L) and HRP (1:10,000 versus 1:2500 dilutions) concentrations, although the standard curve range was the same between studies. Climate and daylight hour differences between regions (Washington DC versus Chiang Mai) could have had an effect [40]. For example, Park and Tokura [41] found that brighter light conditions during the day resulted in higher concentrations of sIgA during nocturnal sleep in humans.…”
Section: Discussionmentioning
confidence: 99%
“…During exposure to acute stressors, secretory IgA (sIgA) levels usually increase (Bosch et al, 2002), probably in response to the short‐term stress‐induced enhancement of immune function (Dhabhar, 2014). In contrast, during chronic stress, sIgA levels typically decline (Gleeson & Cripps, 2015; Viena et al, 2012), presumably as a result of the immunosuppressive effect of long‐term elevations in GC concentrations (Sapolsky, 2000). Therefore, the modulation of sIgA production is associated with the duration as well as with the intensity of the stressor.…”
Section: Introductionmentioning
confidence: 99%