Ontogeny of the corticotrophin-releasing hormone system in slow- and fast-growing chicks (Gallus gallus)

Khan, Md. Sakirul Islam; Shigeoka, Chisa; Takahara, Yuriko; Matsuda, Seiji; Tachibana, Tetsuya

doi:10.1016/j.physbeh.2015.06.033

Cited by 8 publications

(3 citation statements)

References 50 publications

(58 reference statements)

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“…Hirata et al (2016) and Lyons et al (1993), that suggests that social isolation can directly elevates physiological rates. This is a broadly based finding for schooling fishes (Nadler et al, 2016; Parker, 1973; Schleuter et al, 2007), birds (Khan et al, 2015; Soleimani et al, 2012) and mammals (Krause and Ruxton, 2002; Martin et al, 1980; Rushen et al, 1999). Generally, the hypothalamic-pituitary-adrenocortical (HPA) system is implicated in these responses (Hennessy et al, 2009; Hernandez et al, 2010; Herskin et al, 2007).…”

Section: Discussionmentioning

confidence: 53%

Metabolic rate and hypoxia tolerance are affected by group interactions and sex in the fruit fly (Drosophila melanogaster): new data and a literature survey

Burggren

Souder

2017

Biology Open

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Population density and associated behavioral adjustments are potentially important in regulating physiological performance in many animals. In r-selected species like the fruit fly (Drosophila), where population density rapidly shifts in unpredictable and unstable environments, density-dependent physiological adjustments may aid survival of individuals living in a social environment. Yet, how population density (and associated social behaviors) affects physiological functions like metabolism is poorly understood in insects. Additionally, insects often show marked sexual dimorphism (larger females). Thus, in this study on D. melanogaster, we characterized the effects of fly density and sex on both mass-specific routine oxygen consumption (V̇O2) and hypoxia tolerance (PCrit). Females had significantly lower routine V̇O2 (∼4 µl O2 mg−1 h−1) than males (∼6 µl O2 mg−1 h−1) at an average fly density of 28 flies·respirometer chamber−1. However, V̇O2 was inversely related to fly density in males, with V̇O2 ranging from 4 to 11 µl O2 mg−1 h−1 at a density of 10 and 40 flies·chamber−1, respectively (r2=0.58, P<0.001). Female flies showed a similar but less pronounced effect, with a V̇O2 of 4 and 7 µl O2 mg−1 h−1 at a density of 10 and 40 flies·chamber−1, respectively (r2=0.43, P<0.001). PCrit (∼5.5 to 7.5 kPa) varied significantly with density in male (r2=0.50, P<0.01) but not female (r2=0.02, P>0.5) flies, with higher fly densities having a lower PCrit. An extensive survey of the literature on metabolism in fruit flies indicates that not all studies control for, or even report on, fly density and gender, both of which may affect metabolic measurements.

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Section: Discussionmentioning

confidence: 53%

Metabolic rate and hypoxia tolerance are affected by group interactions and sex in the fruit fly (Drosophila melanogaster): new data and a literature survey

Burggren

Souder

2017

Biology Open

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“…The layer is slower-growing and developed for egg production, while the broiler is fast-growing and selected for meat production. It is known that layers and broilers have different physiological and behavioral responses to stressors ( Khan et al, 2015 ). Future studies need to analyze the mRNA expression of NPGL , NPGM , and HDC in broilers.…”

Section: Discussionmentioning

confidence: 99%

Effect of Stressors on the mRNA Expressions of Neurosecretory Protein GL and Neurosecretory Protein GM in Chicks

et al. 2022

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We recently discovered novel cDNAs encoding the precursors of two small secretory proteins, neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM), in the mediobasal hypothalamus (MBH) of chickens. In addition, we found colocalization of NPGL, NPGM, and histidine decarboxylase (HDC; histamine-producing enzyme) in same neurons of the medial mammillary nucleus of the hypothalamus. In this study, we elucidated the effect of several stresses, including food deprivation, environmental heat, inflammation, and social isolation, on the mRNA expression of NPGL, NPGM, and HDC in chicks using real-time PCR. Food deprivation for 24 h increased NPGM mRNA expression in the MBH. On the other hand, an environmental temperature of 37°C for 24 h did not affect their mRNA expression. Six hours after intraperitoneal injection of lipopolysaccharide, an inducer of inflammation, the mRNA expression of NPGM, but not that of NPGL and HDC increased. Social isolation for 3 h induced an increase in the mRNA expression of NPGL, NPGM, and HDC. These results indicate that NPGM, but not NPGL or HDC, may participate in several physiological responses to stress in chicks.

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“…It was reported that brain-derived neurotrophic factor ( BDNF ) activated cholesterol de novo synthesis in the brain ( Petrov et al., 2016b ). Although hypothalamic neuropeptide Y ( NPY ) and corticotropin-releasing hormone ( CRH ) were key regulatory factors in avian metabolism-related function such as feed intake ( Zhang et al., 2015 ), growth performance ( Kalra et al., 1991 , Blankenship et al., 2016 ), and stress response ( Khan et al., 2015 ). However, evidences linking hypothalamic cholesterol metabolism and the expression of these functional neuropeptides are scarce in avian species.…”

Section: Introductionmentioning

confidence: 99%

Fetal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in offspring cockerels with modification of promoter DNA methylation

Idriss

Sun

et al. 2020

Poultry Science

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In documents, maternal betaine modulates hypothalamic cholesterol metabolism in chicken posthatchings, but it remains unclear whether this effect can be passed on by generations. In present study, eggs were injected with saline or betaine at 2.5 mg/egg, and the hatchlings (F1) were raised under the same condition until sexual maturation. Both the control group and the betaine group used artificial insemination to collect sperm from their cockerels. Fertilized eggs were incubated, and the hatchlings of the following generation (F2) were raised up to 64 D of age. F2 cockerels in betaine group showed significantly ( P < 0.05) lower body weight, which was associated with significantly decreased ( P < 0.05) hypothalamic content of total cholesterol and cholesterol ester. Concordantly, hypothalamic expression of cholesterol biosynthetic genes, SREBP2 and HMGCR , were significantly downregulated ( P < 0.05), together with cholesterol conversion-related and excretion-related genes, CYP46A1 and ABCA1 . These changes coincided with a significant downregulation in mRNA expression of regulatory neuropeptides including brain-derived neurotrophic factor, neuropeptide Y, and corticotropin-releasing hormone. Moreover, genes involved in methyl transfer cycle were also modified. Betaine homocysteine methyltransferase ( P < 0.05) was downregulated, yet DNA methyltransferase1 tended to be upregulated ( P = 0.06). S-adenosyl methionine/S-adenosylhomocysteine ratio was higher in the hypothalamus of betaine-treated F2 cockerels, which was associated with significantly modified CpG methylation on the promoter of those affected genes. These results suggested that betaine might regulate central cholesterol metabolism and hypothalamic expression of genes related to brain function by altering promoter DNA methylation in F2 cockerels.

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Ontogeny of the corticotrophin-releasing hormone system in slow- and fast-growing chicks (Gallus gallus)

Cited by 8 publications

References 50 publications

Metabolic rate and hypoxia tolerance are affected by group interactions and sex in the fruit fly (Drosophila melanogaster): new data and a literature survey

Metabolic rate and hypoxia tolerance are affected by group interactions and sex in the fruit fly (Drosophila melanogaster): new data and a literature survey

Effect of Stressors on the mRNA Expressions of Neurosecretory Protein GL and Neurosecretory Protein GM in Chicks

Fetal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in offspring cockerels with modification of promoter DNA methylation

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