Ontogeny of the human fetal, neonatal, and infantile basioccipital bone: Traditional and extended eigenshape geometric morphometric analysis

Zdilla, Matthew J.; Pancake, Jacob; Russell, Mary Jo; Koons, Aaron W.

doi:10.1002/ar.24838

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…More promising results in terms of bone formation were expected for G4; however, the fact that in vitro cell expansion takes a long time must be considered [64], as well as the embryological origin of the mandible, which derives from intramembranous ossification, with bone repair thus being slower when compared to endochondral bones. Intramembranous ossification, vascularization and surrounding soft tissues must be considered [3,74] since these factors are determinants for the choice of membrane to be used as implant.…”

Section: Microscopic Results and Morphometric Analysis Of Newly Forme...mentioning

confidence: 99%

“…2023, 14, x FOR PEER REVIEW 12 of 20 embryological origin of the mandible, which derives from intramembranous ossification, with bone repair thus being slower when compared to endochondral bones. Intramembranous ossification, vascularization and surrounding soft tissues must be considered [3,74] since these factors are determinants for the choice of membrane to be used as implant.…”

Section: Microscopic Results and Morphometric Analysis Of Newly Forme...mentioning

confidence: 99%

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In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair

Cunha

Maia

Iatecola

et al. 2023

JFB

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Natural polymers are increasingly being used in tissue engineering due to their ability to mimic the extracellular matrix and to act as a scaffold for cell growth, as well as their possible combination with other osteogenic factors, such as mesenchymal stem cells (MSCs) derived from dental pulp, in an attempt to enhance bone regeneration during the healing of a bone defect. Therefore, the aim of this study was to analyze the repair of mandibular defects filled with a new collagen/chitosan scaffold, seeded or not with MSCs derived from dental pulp. Twenty-eight rats were submitted to surgery for creation of a defect in the right mandibular ramus and divided into the following groups: G1 (control group; mandibular defect with clot); G2 (defect filled with dental pulp mesenchymal stem cells—DPSCs); G3 (defect filled with collagen/chitosan scaffold); and G4 (collagen/chitosan scaffold seeded with DPSCs). The analysis of the scaffold microstructure showed a homogenous material with an adequate percentage of porosity. Macroscopic and radiological examination of the defect area after 6 weeks post-surgery revealed the absence of complete repair, as well as absence of signs of infection, which could indicate rejection of the implants. Histomorphometric analysis of the mandibular defect area showed that bone formation occurred in a centripetal fashion, starting from the borders and progressing towards the center of the defect in all groups. Lower bone formation was observed in G1 when compared to the other groups and G2 exhibited greater osteoregenerative capacity, followed by G4 and G3. In conclusion, the scaffold used showed osteoconductivity, no foreign body reaction, malleability and ease of manipulation, but did not obtain promising results for association with DPSCs.

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Section: Microscopic Results and Morphometric Analysis Of Newly Forme...mentioning

confidence: 99%

Section: Microscopic Results and Morphometric Analysis Of Newly Forme...mentioning

confidence: 99%

In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair

Cunha

Maia

Iatecola

et al. 2023

JFB

View full text Add to dashboard Cite

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“…Thus, the glenoid is likely more resistant to degradation in skeletal remains. This notion is similar, to the forensic value of the relatively robust basioccipital bone (which forms via endochondral ossification) when compared to the parietal bone (which forms via intramembranous ossification) in identifying the age-at-death from fetal cranial remains, for example (Zdilla et al, 2022).…”

Section: Discussionmentioning

confidence: 69%

Glenoid shape is sexually dimorphic

Zdilla

French

Sowinski

et al. 2023

Proc. W. Va. Acad. Sci.

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Uniform assessment of the glenoid anatomy is fundamental in establishing uniform standards of care. Subjectivity in classification inherent in the absence of quantification permits deficiency in glenoid assessment methods (e.g., Walch classifications). Therefore, this report aims to objectively quantify the variance of glenoid fossa contours in both sexes via geometric morphometric techniques. A total of 135 glenoid fossae from 135 adult Mexican individuals, who had undergone CT scanning for non-shoulder-related reasons, were randomly selected for this study. Geometric morphometric analysis, including principal component analysis, canonical variate analysis, and two-block partial least squares analysis, was performed on glenoid contours in coronal and axial planes among males and females of varied age groups. The canonical variate analysis of the glenoid revealed sexual dimorphism in both the coronal and axial glenoid contours. Males tend to have a move concave glenoid contour than females, especially in the axial plane. Partial least squares analysis revealed a shape-relationship between coronal and axial contours— when coronal contours are relatively concave, axial contours also exhibit concavity; conversely, when there is minimal concavity in one dimension, there tends to be minimal concavity in the other. This manuscript establishes a novel means of assessing the glenoid cavity through geometric morphometrics; in doing so, the objective and quantifiable methods can be an important supplement to evolving glenoid assessments such as the Walch classification system. The novel approach used in this research revealed sexual dimorphism in the shape of the glenoid cavity as well as a relationship between coronal and axial contours.

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Assessing the morphology and bone mineral density of the immature pars lateralis as an indicator of age

Thornton,

Mendelow,

Hutchinson

2023

Int J Legal Med

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Age estimation is crucial when the state of personhood is a mitigating factor in the identification of immature human remains. The maturation sequence of immature bones is a valuable alternative to dental development and eruption standards. Bordering the foramen magnum and pars basilaris, the pars lateralis is somewhat understudied. The aim of this study was to comprehensively describe the morphology of the immature human pars lateralis bone. Human pars laterali were sourced from the crania of 103 immature individuals of unknown provenance from the Johannesburg Forensic Paediatric Collection (JFPC), University of the Witwatersrand (HREC-Medical: M210855). The study sample was subdivided into early prenatal (younger than 30 gestational weeks; n = 32), prenatal (30–40 gestational weeks, n = 41) and postnatal (birth to 7.5 months, n = 30) age groups. The morphology of the pars laterali was studied using a combination of bone mineral density pattern assessments, geometric morphometrics and stereomicroscopy. Bone mineral density in postnatal individuals was lower when compared with the prenatal individuals. No statistically significant differences between density points were noted. The overall shape of the pars lateralis changed from a triangular shape in the early prenatal individuals to a fan-like quadrilateral bone in postnatal individuals. The angulation of the medial border for the foramen magnum highlighted a change in shape between straight in the early prenatal cohort to V-shaped in the postnatal individuals. The various technical approaches used in the current study provided detailed descriptions of the pars lateralis which establishes a valuable foundation for diagnostic criteria employing morphological predictors for biological profiling.

show abstract

Ontogeny of the human fetal, neonatal, and infantile basioccipital bone: Traditional and extended eigenshape geometric morphometric analysis

Cited by 4 publications

References 47 publications

In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair

In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair

Glenoid shape is sexually dimorphic

Assessing the morphology and bone mineral density of the immature pars lateralis as an indicator of age

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