Ontogeny of the novel tachykinins neurokinin A, neurokinin B and neuropeptide K in the rat central nervous system

Díez‐Guerra, F. Javier; Veira, Jose Antonio Rodriguez; Augood, Sarah J.; Emson, Piers C.

doi:10.1016/0167-0115(89)90251-6

Cited by 24 publications

(9 citation statements)

References 25 publications

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“…and 5-HT systems in the brain has been obtained by using different methodological approaches such as fluorescence histochemistry, immunocytochemistry of enzymes, amine uptake, radioenzymatic assays, and HPLC (Pares-Herbute et al, 1989, and references cited therein). Similarly, isolated reports of the ontogenetic development of enkephalin and tachykinin neurons using immunocytochemistry or radioimmunoassay for the determination of peptide levels, ligand binding studies for receptors, and Northern blot analysis or in situ hybridization histochemistry for the determination of the abundance of peptide-encoding mRNAs are available (Bayon et al, 1979;Patey et al, 1980;Inagaki et al, 1982;Palmer et al, 1982;Pickel et al, 1982;Tsang et a]., 1982;McDowell and Kitchen, 1987;Schwartz and Simatov, 1988;Yoshikawa and Aizawa, 1988;Diez-Guerra et al, 1989;Tecott et al, 1989;Haverstick et al, 1990). The peptide measurements in the ontogenetic studies were by and large done with immunocytochemical methods, which have the advantage of demonstrating the topographical and structural distribution.…”

Section: General Considerationsmentioning

confidence: 99%

Dopamine‐Dependent Postnatal Development of Enkephalin and Tachykinin Neurons of Rat Basal Ganglia

Sivam

Krause

Breese

et al. 1991

Journal of Neurochemistry

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The influence of deprivation of the neurotransmitter dopamine (DA) on the development of [Met5]-enkephalin (ME) and substance P (SP) neuropeptide systems of the striatum was investigated in Sprague-Dawley rats. The neurotoxin 6-hydroxydopamine (6-OHDA) was used to induce DA deficiency on postnatal day 3 in rats, and the animals were killed at different postnatal time points until 35 days of age. The levels of ME and SP were determined by radioimmunoassay, and the abundance of preproenkephalin (PPE) and preprotachykinin (PPT) mRNA in the striatum was assessed by Northern blot hybridization analysis. The concentrations of DA, 5-hydroxytryptamine (5-HT), and their acid metabolites were determined by HPLC with electrochemical detection. The postnatal development of the PPE-derived peptide ME and the PPT-derived peptide SP closely paralleled the appearance of the respective mRNAs coding for these peptides. The dopaminergic lesion with 6-OHDA led to a marked depletion of DA and its metabolites but produced an increase in content of 5-HT and its metabolite in the striatum. The lesion did not affect the ME and PPE mRNA levels in the striatum up to 25 days but increased the levels at 35 days. In contrast, a decreased developmental expression in SP and PPT mRNA was observed throughout the observation period. The lesion failed to influence the development of the mRNA coding for the structural protein beta-actin. The results indicate that the normal development of enkephalin, tachykinin, and 5-HT systems of the striatum is dependent on the availability of DA, the integrity of dopaminergic neurons, or both. The studies provide evidence for an interrelationship and interdependence between the development of neurotransmitter and neuropeptide systems. It is suggested that an early developmental abnormality in the DA system could permanently alter the neuropeptide systems, which in turn could influence the progression and expression of the DA-deficiency state parkinsonism, Lesch-Nyhan disease, or both.

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Section: General Considerationsmentioning

confidence: 99%

Dopamine‐Dependent Postnatal Development of Enkephalin and Tachykinin Neurons of Rat Basal Ganglia

Sivam

Krause

Breese

et al. 1991

Journal of Neurochemistry

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“…Therefore these data suggest that unknown maturational factors selectively promote SP expression in growing neurons. Strikingly, tachykinins neurokinin A, neurokinin B, and neuropeptide K have the same ontogenic development as SP (Diez-Guerra et al, 1989). Two different genes encode for these tachykinins (Carter and Krause, 1990;Kotani et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Substance P immunoreactivity of rat brain stem neurons in primary culture

Jacquin¹,

Denizot²,

Denavit-Saubié³

1992

J of Neuroscience Research

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Substance P (SP)-ergic neurons from 16/17 day-embryonic rat brain stem in primary culture were identified by immunocytochemistry using biotinylated avidin and phosphatase alkaline methods with affinity-purified anti-SP antibodies. An average of 84% of neurons contained SP from day 9 to day 21 after plating. These in vitro data show that SP-containing neurons develop in our culture conditions. SP may act as a maturation factor as well as a neurotransmitter.

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“…The somatodendritic phenotypes of medium tachykinin neurons in feline neostriatum match tachykinin cells of unknown somatodendritic phenotypes commonly reported in mammals [1,2,3,6,7,8,9]. Principal and minor variants of medium spiny tachykinin neurons are identical to medium spiny neurons with unknown neuromodulator signatures shown by Golgi impregnation, which constitute approximately 95% of neurons in adult feline neostriatum [19].…”

Section: Discussionmentioning

confidence: 99%

“…In immature rats and cats, tachykinins show a pattern of early, progressive expression in numerous small to medium neurons in the neostriatum (caudate nucleus, putamen and, when separate, their intervening cell bridges) during middle and late fetal periods, prior to their perinatal establishment of significant synaptic connectivity via local axon collaterals or descending (i.e. striatonigral) axon projections [1,2]. The morphogenetic properties of these cells are largely uncharted, and their characterization is the first objective of the present study.…”

Section: Introductionmentioning

confidence: 99%

Tachykinin-Immunoreactive Neurons in Developing Feline Neostriatum: Somatodendritic Morphogenesis Demonstrated by Combined Immunohistochemistry/Golgi Impregnation-Gold Toning

Fisher

Boylan²

2011

Dev Neurosci

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This investigation was designed to survey and characterize the development of a key link between chemically mediated neurotransmission and neuronal cytoarchitecture in mammalian basal ganglia. Peroxidase immunohistochemical and Golgi impregnation/gold toning methods were combined to doubly label the tachykinin neuromodulator signature and somatodendritic structure of neostriatal neurons in late fetal, postnatal and adult cats. The results supported 3 conclusions of considerable significance. (1) Colocalization of immunohistochemical and Golgi impregnation/gold toning labels is a feasible, rational and productive means to identify and determine the somatodendritic morphogenesis of tachykinin neurons. (2) The application of this method to developing feline neostriatum demonstrates directly that the principal tachykinin cells are medium-sized spiny neurons, which undergo progressive growth and elaboration of cell bodies, dendritic arbors and dendritic spines during the late fetal and postnatal periods. (3) There is a strong but incomplete concordance between tachykinin and medium-sized spiny neuronal phenotypes, because a minor variant of medium-sized spiny neurons and rare subgroups of medium- and large-sized sparse spiny neurons also show the tachykinin neuromodulator signature. Taken together, these results suggest that neostriatal neurons show an early commitment to heterogeneous tachykinin phenotypes, although the full and final expression of their somatodendritic characteristics coincides with synaptogenesis.

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Ontogeny of the novel tachykinins neurokinin A, neurokinin B and neuropeptide K in the rat central nervous system

Cited by 24 publications

References 25 publications

Dopamine‐Dependent Postnatal Development of Enkephalin and Tachykinin Neurons of Rat Basal Ganglia

Dopamine‐Dependent Postnatal Development of Enkephalin and Tachykinin Neurons of Rat Basal Ganglia

Substance P immunoreactivity of rat brain stem neurons in primary culture

Tachykinin-Immunoreactive Neurons in Developing Feline Neostriatum: Somatodendritic Morphogenesis Demonstrated by Combined Immunohistochemistry/Golgi Impregnation-Gold Toning

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