Ontogeny of the (pro)renin receptor

Song, Renming; Preston, Graeme; Yosypiv, Ihor V.

doi:10.1038/pr.2013.63

Cited by 15 publications

(2 citation statements)

References 33 publications

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“…V-ATPases are associated with membranes of intracellular compartments in most cell types and as such contribute to vesicle trafficking, protein degradation and intracellular signaling. The (P)RR is found in the developing kidney with high protein levels during gestation, and declines in the postnatal period [30]. The ACE-2/Ang (1-7)/Mas receptor pathway, referred to as the 'protective arm' of RAAS, is present during development [6,[31][32][33].…”

Section: Developmental Changes In the Raasmentioning

confidence: 99%

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

et al. 2020

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Adverse events during fetal life such as insufficient protein intake or elevated transfer of glucocorticoid to the fetus may impact cardiovascular and metabolic health later in adult life and are associated with increased incidence of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin-angiotensin-aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation of RAAS in rodents at any step from angiotensinogen to angiotensin II (ANGII) type 1 receptor (AT 1 ) receptors or pharmacologic inhibition leads to complex developmental injury to the kidneys that has also been observed in human case reports. Deletion of the 'protective' arm of RAAS, angiotensin converting enzyme (ACE) 2 (ACE-2) and G-protein coupled receptor for Angiotensin 1-7 (Mas) receptor does not reproduce the AT 1 phenotype. The changes comprise fewer glomeruli, thinner cortex, dilated tubules, thicker arterioles and arteries, lack of vascular bundles, papillary atrophy, shorter capillary length and volume in cortex and medulla. Altered activity of systemic and local regulators of fetal-perinatal RAAS such as vitamin D and cyclooxygenase (COX)/prostaglandins are associated with similar injuries. ANGII-AT 1 interaction drives podocyte and epithelial cell formation of vascular growth factors, notably vascular endothelial growth factor (VEGF) and angiopoietins (Angpts), which support late stages of glomerular and cortical capillary growth and medullary vascular bundle formation and patterning. RAAS-induced injury is associated with lower glomerular filtration rate (GFR), lower renal plasma flow, kidney fibrosis, up-regulation of sodium transporters, impaired sodium excretion and salt-sensitive hypertension. The renal component and salt sensitivity of programmed hypertension may impact dietary counseling and choice of pharmacological intervention to treat hypertension.

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Section: Developmental Changes In the Raasmentioning

confidence: 99%

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

et al. 2020

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“…The Western blot with the antibody to the AT 4 receptor showed selective signal of expected size (ϳ165 kDa, 140 kDa in brain) (28). The (P)RR antibody selectively detected a protein of the expected size of about 42 kDa, with a doublet seen in brain samples, probably because of differences in (P)RR glycosylation (62). PC-12 cells, which originate from rat pheochomocytoma, also ex-pressed both types of receptors.…”

Section: Localization and Expression Of The Nonclassical Ras Receptormentioning

confidence: 93%

Regulation of nonclassical renin-angiotensin system receptor gene expression in the adrenal medulla by acute and repeated immobilization stress

Nostramo

Serova

Lauková

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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The involvement of the nonclassical renin-angiotensin system (RAS) in the adrenomedullary response to stress is unclear. Therefore, we examined basal and immobilization stress (IMO)-triggered changes in gene expression of the classical and nonclassical RAS receptors in the rat adrenal medulla, specifically the angiotensin II type 2 (AT2) and type 4 (AT4) receptors, (pro)renin receptor [(P)RR], and Mas receptor (MasR). All RAS receptors were identified, with AT2 receptor mRNA levels being the most abundant, followed by the (P)RR, AT1A receptor, AT4 receptor, and MasR. Following a single IMO, AT2 and AT4 receptor mRNA levels decreased by 90 and 50%, respectively. Their mRNA levels were also transiently decreased by repeated IMO. MasR mRNA levels displayed a 75% transient decrease as well. Conversely, (P)RR mRNA levels were increased by 50% following single or repeated IMO. Because of its abundance, the function of the (P)RR was explored in PC-12 cells. Prorenin activation of the (P)RR increased phosphorylation of extracellular signal-regulated kinase 1/2 and tyrosine hydroxylase at Ser(31), likely increasing its enzymatic activity and catecholamine biosynthesis. Together, the broad and dynamic changes in gene expression of the nonclassical RAS receptors implicate their role in the intricate response of the adrenomedullary catecholaminergic system to stress.

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Vasoactive Factors and Blood Pressure in Children

Yosypiv¹

2023

Pediatric Hypertension

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Ontogeny of the (pro)renin receptor

Cited by 15 publications

References 33 publications

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Regulation of nonclassical renin-angiotensin system receptor gene expression in the adrenal medulla by acute and repeated immobilization stress

Vasoactive Factors and Blood Pressure in Children

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