Ontogeny of α1andα2-adrenoceptors in rat brain

Morris, Margaret J.; Dausse, Jean‐Pierre; Devynck, Marie‐Aude; Meyer, Philippe

doi:10.1016/0006-8993(80)91178-6

Cited by 109 publications

(49 citation statements)

References 7 publications

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“…An excess of neurotransmitter receptors followed by elimination has been reported for selected cortical areas in rodents and cats (27)(28)(29)(30)(31)(32)(33)(34), but synchronous overproduction of several neurotransmitter receptors in anatomically and functionally diverse areas of the neocortex is unexpected. We attribute the observed changes in the density of neurotransmitter receptors to an initial overproduction followed by a decrease of binding sites during infancy and adolescence.…”

Section: Methodsmentioning

confidence: 98%

Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.

Lidow

Goldman‐Rakic

Rakić

1991

Proc. Natl. Acad. Sci. U.S.A.

199

116

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A remarkable diversity of neurotrausmitter receptors develops concurrently in disparate areas of the primate cerebral cortex. The density of dopaminergic, adrenergic, serotonergic, cholinergic, and GABAergic receptors (where GABA is r-aminobutyric acid) in rhesus monkey reaches a maximum level between 2 and 4 months of age and then declines gradually to adult levels in all layers of sensory, motor, and association regions. The synchronized development of neurotransmitter receptors in diverse layers and regions of the neocortex occurs parn passu with synaptogenesis, demonstrating unusual coordination of biochemical and structural maturation and supporting the hypothesis that the entire cerebral cortex matures as an integrated network, rather than as a system-by-system cascade.

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Section: Methodsmentioning

confidence: 98%

Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.

Lidow

Goldman‐Rakic

Rakić

1991

Proc. Natl. Acad. Sci. U.S.A.

199

116

View full text Add to dashboard Cite

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“…Experimental work has focused on the cellular mechanisms involved with the accumulation and localization of neuroreceptors (Zukin et al, 1975;Enna et al, 1976;Bevan and Steinbath, 1977;Burden, 1977a;Harden et al, 1977;Pardo et al, 1977;Goodman and Spitzer, 1980;Morris et al, 1980;Hays et al, 1981;Kent et al, 1982;Weiss et al, 1984), the determination of transmitter and receptor type from an initially large array (Potter et al, 198 1;Bixby and Spitzer, 1982;Black et al, 1984;Doupe et al, 1985) the maturation of receptor form and function (Papanno, 1972;Burden, 1977b;Obata et al, 1978;Sakmann and Brenner, 1978;Ziskind and Dennis, 1978;Hall et al, 1983;Mueller et al, 1983), and the ontogenetic roles they may potentially have in addition to synaptic transmission (Lauder and Krebs, 1978;Woolf et al, 1979;Lauder et al, 1981;Haydon et al, 1984). The present results highlight a unique phenomenon in transmitter system development: a progressive alteration in the distribution of the glycine receptor across one axis of a central auditory nucleus.…”

Section: Discussionmentioning

confidence: 99%

“…Given the aforementioned influence of volume increase, it is likely that the appearance of a receptor gradient derives from a selective loss of receptors ventrally. Several neuroreceptors demonstrate a supramaximal concentration followed by a decline during postnatal development (Harden et al, 1977;Morris et al, 1980;Hays et al, 1981;Kent et al, 1982). HEARING ONSET .8.5 kHz VOLUME-0.307mm3 VOLUME-0.592mm3…”

Section: Influence Of Nucleus Volume and Neuron Densitymentioning

confidence: 99%

Development of glycine receptor distribution in the lateral superior olive of the gerbil

Sanes

Wooten

1987

J. Neurosci.

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The concentration and relative distribution of glycine receptors were determined for the gerbil lateral superior olive at several postnatal ages. Quantitative autoradiographic techniques revealed significant 3H- strychnine binding to all regions of the nucleus from 4 to 90 d. However, during the first 20 d, a nonuniform distribution of binding emerged, such that the greatest concentration of receptor was found in the high-frequency region of the nucleus. An analysis of neuron packing density showed an approximate 2-fold distribution along the same axis at all ages. This evidence is consistent with an elimination of glycine receptors in the ventral region of the lateral superior olive as maturation progresses.

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“…Ontogeny of a-adrenoreceptors in the rat brain has been observed only in 8-day old rats but their density was lower than in the adult rats (9). The maturation of a-adrenergic mechanisms is reported only after puberty (10).…”

mentioning

confidence: 99%

The Possible Role of Androgenic Hormones in Maturation of Alpha₂‐Adrenergic Mechanisms in the Rat

Kiem¹,

Bartha²,

Makara³

1990

J Neuroendocrinology

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In order to get better characterization of androgenic hormones on the functionality of the a,-adrenergic system and widen our previous studies, we investigated the effect of clonidine on the growth hormone (GH) secretion in male Wistar rats of various ages: 7-, 14-and 30-day old and adult, adult male castrated rats with and without testosterone treatment.Two different patterns of the GH response to clonidine have been observed in the control and testosterone-treated young animals: clonidine at the dose 15 pg/kg intraperitoneally had no effect on the GH secretion in 7-to 14-day old rat pups. In contrast, its effect appeared following the increase in the plasma testosterone concentration induced by pretreatment with testosterone (5 mglkg subcutaneously for 4 days) in these animals. In 30-day old rats clonidine affected GH secretion and this influence was more pronounced in the testosterone-treated animals than in the controls.The decrease in the circulating testosterone levels caused by castration in adult male rats caused a decreased GH response to clonidine. Moreover, there was a tendency for the GH response to return in 4-week old animals. The effect of clonidine has been restored by testosterone replacement of castrates.Testosterone administration decreased basal plasma GH levels in the pups. However, it triggered the ultradian surges of GH secretion which were absent in the young animals.Clonidine had no effect on the corticosterone secretion in 7-day old animals. Testosterone treatment induced a response in the 7-day old rat and markedly potentiated its effect on the secretion of this hormone in 14-and 30-day old animals, respectively.Neither progesterone nor hydrocortisone influenced the GH-releasing effect of clonidine. Hydrocortisone markedly inhibited the basal-and clonidine-induced corticosterone secretion.The results of the present study indicate an important role of androgenic hormones in inducing and/or maintaining the effectiveness/sensitivity of the a,-adrenergic receptor system and suggest a possible role for the androgenic hormones in the maturation of a-adrenergic mechanisms in the rat.The a,-adrenergic receptor agonist clonidine is a potent stimulus of growth hormone (GH) secretion. Studies using agonists and antagonists have shown that qadrenergic receptors mediate stimulatory action for G H release in the rat (1-4), probably via GH-releasing hormone (GHRH) (5, 6).In the rat, the development of catecholamine-containing fibres was observed at the early postnatal period of 5 days of age (7) and correlated with the development of the hypothalamo-hypophysial portal plexus (8). Ontogeny of a-adrenoreceptors in the rat brain has been observed only in 8-day old rats but their density was lower than in the adult rats (9). The maturation of a-adrenergic mechanisms is reported only after puberty (10).The new-born rat has fairly constant plasma G H levels and lacks the ultradian surges of G H secretion observed in adult animals (11-13). In the adult rat testosterone could modulate the phasic rele...

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Ontogeny of α1andα2-adrenoceptors in rat brain

Cited by 109 publications

References 7 publications

Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.

Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.

Development of glycine receptor distribution in the lateral superior olive of the gerbil

The Possible Role of Androgenic Hormones in Maturation of Alpha₂‐Adrenergic Mechanisms in the Rat

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Ontogeny of α1andα2-adrenoceptors in rat brain

Cited by 109 publications

References 7 publications

Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.

Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.

Development of glycine receptor distribution in the lateral superior olive of the gerbil

The Possible Role of Androgenic Hormones in Maturation of Alpha2‐Adrenergic Mechanisms in the Rat

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The Possible Role of Androgenic Hormones in Maturation of Alpha₂‐Adrenergic Mechanisms in the Rat