Onycholemmal carcinoma: A morphologic comparison of 6 reported cases

Onycholemmal carcinoma with prominent dystrophic calcification and review of the literature

“…The presence of dystrophic calcification has been reported previously in one onycholemmal carcinoma . This Case expands the differential diagnosis of calcified nail unit lesions; subungual calcified epidermoid inclusions, subungual chondroblastoma, and epidermoid cyst of the distal phalanx (an intraosseous lesion) are also diagnostic considerations.…”

“…Recognition of this entity is important to ensure that appropriate, but not excessively aggressive, management is pursued. Among Cases with reported treatments, nine of thirteen (69%) lesions were treated by amputation or distal interphalangeal joint disarticulation . One lesion was managed with radiation, one with Mohs surgery, and two with more conservative re‐excisions .…”

“…Onycholemmal carcinoma is a rare but distinctive variant of squamous cell carcinoma arising from the nail isthmus of the proximal nail bed . Clinically, it is characterized by its indolent, slow‐growing nature and additional nonspecific findings such as onycholysis, pain, periungual erythema, and edema.…”

“…Since its initial description in 2004, approximately thirteen cases have been reported in the English‐language literature . These cases are summarized in Table .…”

“…Onycholemmal carcinoma is a rare but distinctive variant of squamous cell carcinoma arising from the nail isthmus of the proximal nail bed. 1 Clinically, it is characterized by its indolent, slow-growing nature and additional nonspecific findings such as onycholysis, pain, periungual erythema, and edema. Histopathologically, it is distinguished by invasive and infiltrative islands of atypical squamous epithelium demonstrating abrupt keratinization without a granular layer.…”