Onychomycosis caused by <i>Fusarium</i> sp in Sri Lanka: Prevalence, clinical features and response to itraconazole pulse therapy in six cases

Ranawaka, Ranthilaka R.; Silva, Nelun de; Ragunathan, Ramya W

doi:10.1080/09546630801974912

Cited by 20 publications

(24 citation statements)

References 23 publications

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“…in our region is higher than in other countries. Colombia, the United States, and Sri Lanka have reported rates of 6, 6.9, and 6.25 %, respectively [1,14,15]. Moreover, all patients who were diagnosed with onychomycosis caused by Fusarium spp.…”

Section: Resultsmentioning

confidence: 99%

Fusarium spp. is able to grow and invade healthy human nails as a single source of nutrients

Galletti

Negri

Grassi

et al. 2015

Eur J Clin Microbiol Infect Dis

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Onychomycosis caused by Fusarium spp. is emerging, but some factors associated with its development remain unclear, such as whether this genus is keratinolytic. The main aim of the present study was to evaluate the ability of Fusarium to use the human nail as a single source of nutrients. We also performed an epidemiological study and antifungal susceptibility testing of Fusarium spp. that were isolated from patients with onychomycosis. The epidemiological study showed that Fusarium species accounted for 12.4 % of onychomycosis cases, and it was the most common among nondermatophyte molds. The most frequent species identified were F. oxysporum (36.5 %), F. solani (31.8 %), and F. subglutinans (8.3 %). Fluconazole was not active against Fusarium spp., and the response to terbinafine varied according to species. Fusarium was able to grow in vitro without the addition of nutrients and invade healthy nails. Thus, we found that Fusarium uses keratin as a single source of nutrients, and the model proposed herein may be useful for future studies on the pathogenesis of onychomycosis.

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Section: Resultsmentioning

confidence: 99%

Fusarium spp. is able to grow and invade healthy human nails as a single source of nutrients

Galletti

Negri

Grassi

et al. 2015

Eur J Clin Microbiol Infect Dis

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“…Several studies have shown that itraconazole pulse therapy is effective on Fusarium onychomycosis, showing clinical cure in 40–88% of cases . In the study conducted by Ranawaka et al . on six cases of Fusarium onychomycosis, oral itraconazole pulse therapy showed 60% clinical cure at 12 months follow‐up, and the mycological cure was 100%.…”

Section: Discussionmentioning

confidence: 99%

Fusarium onychomycosis: prevalence, clinical presentations, response to itraconazole and terbinafine pulse therapy, and 1‐year follow‐up in nine cases

2015

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“…[13,14] Reports from different parts of the world including India, Sri Lanka, Brazil and Argentina have also described nondermatophytes filamentous fungi as an important cause of onychomycosis. [15][16][17][18] Among non dermatophytes Alternaria alternata, Aspergillus glaucus, Aspergillus tereus and Fusarium species were the predominant isolates in our setup. Ulocladium chartarum, Scedosporium apiospermum, Scedosporium prolificans and Cladophialophora carrionii were also isolated from a few cases highlighting the role in superficial infections.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Superficial and Deep Fungal Isolates in Northern Pakistan

Shujat¹

2014

Virology & Mycology

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Fungi are an important cause of superficial and deep infections in our population. Lack of expertise in proper identification and inadequate diagnostic facilities often lead to underreporting of these infections and thus underestimation of true disease burden. This study was conducted at Department of Microbiology, Armed Forces Institute of Pathology Rawalpindi, Pakistan, from January 2011 through December 2013. Samples included specimen collected from superficial and deep tissues, respiratory tract specimen, blood, bone marrow and other body fluids. Skin (35.1%) and nail (10.2%) samples were the most common specimens from superficial body sites. Tissue specimens from various body organs and bronchoalveolar lavage fluid were the predominant specimens received for investigation of deep seated fungal infections, contributing 34.9% and 5.9% of the total specimens respectively. Yeasts were isolated from 75(22.6%) samples; different species of Candida accounted for majority of the isolates. Growth of molds was detected in 257(77.4%) samples with Aspergillus spp. accounting for 149 (44.9%) of the isolates. Among dermatophytes, Trichophyton interdigitale 13(3.9%) was the most common isolate. Moulds other than dermatophytes were also isolated from skin, hair and nail samples and Alternaria alternata (4.8%) was the most common non-dermatophyte isolated from these sites. Fungal infections and their spectrum varies considerably in different geographical locations and in all cases not responding to antibiotics and high risk groups, a possibility of fungal cause should be sought.

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Onychomycosis caused by Fusarium sp in Sri Lanka: Prevalence, clinical features and response to itraconazole pulse therapy in six cases

Abstract: Our data reconfirmed that Fusarium nail infections are difficult to eradicate. Since the therapeutic reservoir in toenails is 11 months, these patients should be followed up for a total of 12 months before coming to the final conclusion.

Cited by 20 publications

References 23 publications

Fusarium spp. is able to grow and invade healthy human nails as a single source of nutrients

Fusarium spp. is able to grow and invade healthy human nails as a single source of nutrients

Fusarium onychomycosis: prevalence, clinical presentations, response to itraconazole and terbinafine pulse therapy, and 1‐year follow‐up in nine cases

Spectrum of Superficial and Deep Fungal Isolates in Northern Pakistan

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