Onychomycosis caused by <i>Onychocola canadensis</i>: the first report in Estonia and lessons to learn

Järv, H.

doi:10.1111/myc.12281

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…The genus Arachnomyces (family Arachnomycetaceae , order Arachnomycetales; Malloch and Cain 1970 , Guarro et al 1993 ), characterized by the production of brightly coloured cleistothecial ascomata bearing setae, and by the production of an onychocola-like (Sigler et al 1994 ) or a malbranchea-like (Udagawa and Uchiyama 1999 ) asexual morph, have been also implicated in animal and human infections. Specifically, Arachnomyces nodosetosus and Arachnomyces kanei have been reported as causing nail and skin infections in humans (Sigler and Congly 1990 ; Sigler et al 1994 ; Campbell et al 1997 ; Contet-Audonneau et al 1997 ; Kane et al 1997 ; Koenig et al 1997 ; Gupta et al 1998 ; Erbagci et al 2002 ; Gibas et al 2002 ; Llovo et al 2002 ; O’Donoghue et al 2003 ; Gibas et al 2004 ; Stuchlík et al 2011 ; Järv 2015 ; Gupta et al 2016 ). More recently, Arachnomyces peruvianus has been reported to cause cutaneous infection (Brasch et al 2017 ) and A. glareosus was isolated from nail and skin samples (Gibas et al 2004 ; Sun et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty

et al. 2021

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The fungi of the order Onygenales can cause important human infections; however, their taxonomy and worldwide occurrence is still little known. We have studied and identified a representative number of clinical fungi belonging to that order from a reference laboratory in the USA. A total of 22 strains isolated from respiratory tract (40%) and human skin and nails (27.2%) showed a malbranchea-like morphology. Six genera were phenotypically and molecularly identified, i.e. Auxarthron/Malbranchea (68.2%), Arachnomyces (9.1%), Spiromastigoides (9.1%), and Currahmyces (4.5%), and two newly proposed genera (4.5% each). Based on the results of the phylogenetic study, we synonymized Auxarthron with Malbranchea, and erected two new genera: Pseudoarthropsis and Pseudomalbranchea. New species proposed are: Arachnomyces bostrychodes, A. graciliformis, Currahmyces sparsispora, Malbranchea gymnoascoides, M. multiseptata, M. stricta, Pseudoarthropsis crassispora, Pseudomalbranchea gemmata, and Spiromastigoides geomycoides, along with a new combination for Malbranchea gypsea. The echinocandins showed the highest in vitro antifungal activity against the studied isolates, followed by terbinafine and posaconazole; in contrast, amphotericin B, fluconazole, itraconazole and 5-fluorocytosine were less active or lacked in vitro activity against these fungi.

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Section: Introductionmentioning

confidence: 99%

A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty

et al. 2021

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“…The genus Arachnomyces (family Arachnomycetaceae, order Arachnomycetales; Malloch & Cain 1970, Guarro et al 1993, characterized by the production of brightly coloured cleistothecial ascomata bearing setae, and by the production of an onychocola-like (Sigler et al 1994) or a malbranchea-like (Udagawa & Uchiyama 1999) asexual morph, have been also implicated in animal and human infections. Speci cally, Arachnomyces nodosetosus and Arachnomyces kanei have been reported as causing nail and skin infections in humans (Sigler & Congly 1990, Campbell et al 1997, Contet-Audonneau et al 1997, Kane et al 1997, Koenig et al 1997, Gupta et al 1998, Erbagci et al 2002, Gibas et al 2002, Llovo et al 2002, O'Donoghue et al 2003, Gibas et al 2004, Stuchlík et al 2011, Järv 2015, Gupta et al 2016. More recently, Arachnomyces peruvianus has been reported to cause cutaneous infection (Brasch et al 2017) and Arachnomyces glareosus was isolated from nail and skin samples (Gibas et al 2004;Sun et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Rare malbranchea-like fungal isolates from clinical specimens in United States of America.

Rodríguez-Andrade

Cano-Lira

Wiederhold

et al. 2021

Preprint

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The fungi of the order Onygenales can cause important human infections; however, their taxonomy and worldwide occurrence is still little known. We have studied and identified a representative number of clinical fungi belonging to that order from a reference laboratory in the USA. A total of twenty-two strains isolated from respiratory tract (40 %) and human skin and nails (27.2 %) showed a malbranchea-like morphology. Six genera were phenotypically and molecularly identified, i.e. Auxarthron/Malbranchea (68.2 %), Arachnomyces (9.1 %), Spiromastigoides (9.1 %), and Currahmyces (4.5 %), and two newly proposed genera (4.5 % each). Based on the results of the phylogenetic study, we synonymysed Auxarthron to Malbranchea, and erected two new genera: Pseudoarthropsis and Pseudomalbranchea. New species are proposed: Arachnomyces bostrychodes, A. graciliformis, Currahmyces sparsispora, Malbranchea gymnoascoidea, M. multiseptata, M. stricta, Pseudoarthropsis crassispora, Pseudomalbranchea gemmata and Spiromastigoides geomyces, along with a new combination for Malbranchea gypsea. The echinocandins showed the highest in vitro antifungal activity against the studied isolates, followed by terbinafine and posaconazole; in contrast, amphotericin B, fluconazole, itraconazole and 5-fluorocytosine were less active or lacked in vitro activity against these fungi.

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Onychocola canadensis Sigler bei Onychomykose

et al. 2016

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Moulds or non-dermatophyte moulds (NDM) are being increasingly isolated as causative agent of onychomycoses. Known causes of a NDM-OM are Scopulariopsis brevicaulis, Fusarium, Aspergillus, Acremonium, Neoscytalidium dimidiatum, Arthrographis kalrae, and Chaetomium. In this article, 5 patients with suspected nail infection due to Onychocola canadensis are reported for the first time in Germany. Systemic antifungal agents are not considered to be effective in NDM onychomycosis. In individual cases, however, terbinafine seems to be effective in Onychocola canadensis infection of the nails. Treatment of choice represents, however, nontraumatic nail avulsion using 40 % urea ointment followed by antifungal nail lacquer with ciclopirox olamine or amorolfine.

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Onychomycosis caused by Onychocola canadensis: the first report in Estonia and lessons to learn

Cited by 3 publications

References 30 publications

A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty

A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty

Rare malbranchea-like fungal isolates from clinical specimens in United States of America.

Onychocola canadensis Sigler bei Onychomykose

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