Onychomycosis caused by Microsporum canis: Treatment with itraconazole

André, Josette; Doncker, P. De; Laporte, Marianne; Cutsem, J. Van; Wiame, Lucy; Hoof, F Stouffs-Van; Achten, G; Ledoux, Marguerite

doi:10.1016/0190-9622(95)91361-0

Cited by 13 publications

(6 citation statements)

References 8 publications

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“…Close contact with the animal and immunosuppression due to steroid therapy are probably the reasons why Microsporum canis attacked the nail in the present case. In agreement with recent studies on itraconazole therapy of onychomycosis [18], we found that intermittent therapy was just as effective as the daily treatment used by Andre Â [10].…”

Section: Discussionsupporting

confidence: 92%

“…Microsporum canis has also been isolated in apparently healthy nails of patients with acquired immunodeficiency syndrome [16]. All recent cases have been successfully treated, mainly with different protocols of terbinafine [9, 11] or itraconazole [10, 15]. In our case, the source of infection was traced to the patient's cat, confirming that cats with healthy carrier status are a major source of contagion of dermatophyte infections in the Siena area [17].…”

Section: Discussionsupporting

confidence: 63%

“…The clinical manifestations of the few cases of onychomycosis due to M. canis reported in the literature include distal subungual onychomycosis [5], onychodystrophy [9, 10] and proximal subungual onychomycosis [11]. They are therefore similar to the manifestations of onychomycoses due to Trichophyton rubrum , Trichophyton mentagrophytes and Epidermophyton floccosum , which are the usual agents of nail infections.…”

Section: Discussionmentioning

confidence: 99%

“…There have been few reports in the literature of onychomycosis due to Microsporum canis [1–12] and in some cases medical history has revealed previous infection of glabrous skin and of scalp by the same dermatophyte [9–12] and contact with cats [9, 10]. Here we report the first case observed in Siena, in which the principal agent of the dermatophytosis was M. canis , and cats, which are often healthy carriers, were the main source of infection [13].…”

Section: Introductionmentioning

confidence: 95%

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Case report. Onychomycosis due to Microsporum canis

Romano¹,

Paccagnini²,

Pelliccia³

2001

Mycoses

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Case report. Onychomycosis due to Microsporum canis

Romano¹,

Paccagnini²,

Pelliccia³

2001

Mycoses

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“…The patient also contracted tinea pedis and tinea corporis. M. canis predominantly infects the human hair, scalp, and trunk, but rarely infect nails [ 35 ],[ 36 ]. The infection of M. canis was presumably due to the altered immune status of the patient [ 37 ], who well responded to antifungal treatment (terbinafine) during a course of 7 weeks.…”

Section: Discussionmentioning

confidence: 99%

Rapid detection of dermatophytes and Candida albicansin onychomycosis specimens by an oligonucleotide array

Han

Hsu²,

Choi

et al. 2014

BMC Infect Dis

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BackgroundOnychomycosis is a fungal infection of nails, leading to the gradual destruction of the nail plate. Treatment of onychomycosis may need long-time oral antifungal therapy that can have potential side effects, thus accurate diagnosis of the disease before treatment is important. Culture for diagnosis of onychomycosis is time-consuming and has high false-negative rates. To expedite the diagnosis, an oligonucleotide array, based on hybridization between immobilized oligonucleotide probes and PCR products, for direct detection of dermatophytes and Candida albicans in clinical specimens was evaluated.MethodsSpecies-specific oligonucleotide probes designed from the internal transcribed spacer (ITS) regions of the rRNA gene were immobilized on a nylon membrane. The assay procedures consisted of PCR amplification of the ITS using universal primers, followed by hybridization of the digoxigenin-labeled amplicons to probes on the array. Thirty two nail samples (29 patients) were analyzed by the array, and the results were compared with those obtained by culture. Array-positive but culture-negative samples were confirmed by cloning and re-sequencing of the amplified ITS and by reviewing patient’s clinical data. The total recovery of culture and confirmed array-positive but culture-negative results was considered 100% and was used for performance evaluation of both methods.ResultsConcordant results were obtained in 21 samples (10 positives and 11 negatives) by both methods. Eleven samples were array-positive but culture-negative; among them, 9 samples were considered true positives after discrepant analysis. Comparing with culture, the array had significantly higher sensitivity [100% (95% CI 82.2% −100%) vs 52.6% (28.9% −75.5%), p <0.001] and negative predictive value [100% (71.3% −100%) vs 59.1% (36.4% −79.3%), p <0.05), while no significant differences were observed in specificity (84.6% vs 100%, p =0.48) and positive predictive value (90.5% vs 100%, p =1.0). The whole procedures of the array were about 24 h, whilst results from culture take 1 to 3 weeks.ConclusionsThe array offers an accurate and rapid alternative to culture. Rapid diagnosis can expedite appropriate antifungal treatment of onychomycosis. However, the single site nature of this study conducted at a referral hospital invites caution.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-014-0581-5) contains supplementary material, which is available to authorized users.

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