Onychomycosis Due to Aspergillus spp.: a Current Review

Frías-De-León, María Guadalupe; Espinosa-Hernández, Víctor Manuel; Bonifáz, Alexandro; Martínez‐Herrera, Erick

doi:10.1007/s12281-018-0319-8

Cited by 2 publications

(8 citation statements)

References 54 publications

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“…There are still inconsistent reports about the epidemiology of onychomycosis in different age groups 1 . However, the most affected group is the one between 30 and over 60 years 8 . In our study, the most affected age group was 15–64 years old, then the geriatric group, and the least affected were children <14 years old.…”

Section: Discussionmentioning

confidence: 44%

“…In our study, children were not affected (zero cases). Data suggest that the prevalence of onychomycosis may be ≥20% in subjects aged ≥60 years and ≥50% in those aged ≥70 years 8 . The altered metabolism, comorbidities, and less hygiene are causative factors of higher onychomycosis in geriatric patients 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Regarding Aspergillus spp., males were found to be more vulnerable. The differences in onychomycosis prevalence between females and males in different countries may be related to hygienic and cultural behaviors about occupation, esthetic interest, or participation in sports 8,10 …”

Section: Discussionmentioning

confidence: 99%

“…1 As for age, it can occur in any age group, including pediatric and geriatric patients. 8 There are still inconsistent reports about the epidemiology of onychomycosis in different age groups. 1 However, the most affected group is the one between 30 and over 60 years.…”

Section: Discussionmentioning

confidence: 99%

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A 5‐year single‐center study about onychomycosis with a focus on Aspergillus spp. in Albania

Fida,

Prendushi,

Gjylameti

et al. 2023

Int J Dermatology

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BackgroundOnychomycosis is a common nail infection caused by dermatophytes, nondermatophytes molds (NDM), and yeasts. The prevalence of Aspergillus spp. is increasing worldwide. This study aims to describe the epidemiological and microbiological features of onychomycosis, especially for Aspergillus spp.MethodsThis is a 5‐year retrospective study of clinically suspected onychomycosis in one microbiological clinic in Albania. The mycological examination, which included direct microscopic examination of nail scrapings with 20% KOH and culture, was performed on 411 patients. After incubation, we studied the macroscopic characteristics of the colonies, size, shape, and color, and their microscopic examination. We evaluated positive cases for Aspergillus, all cases where Aspergillus was grown in the culture, the microscopy was positive, and the culture was negative for dermatophyte.ResultsOnychomycosis resulted positive in 267 patients (52.9% females vs. 47.1% males). A total of 62.2% resulted infected by dermatophytes, 29.6% by yeasts, and 8.2% by NDM. Onychomycosis resulted more frequent in the age group 15–64 years old (63%). Aspergillus spp. were found in 19 patients from 22 patients with NDM onychomycosis. Males (11 patients) and the age group 15–64 years old (14 patients) were more vulnerable to Aspergillus spp. A. niger, A. flavus, and A. terreus isolated from the nail cultures in our study. The culture resulted more superior to KOH examinations.ConclusionsOur study indicates that NDM, including Aspergillus spp., are still rare findings from fungal examinations. However, dermatologist's clinical suspicion and microbiologist's skills are mandatory in diagnosing and properly managing patients with Aspergillus spp.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A 5‐year single‐center study about onychomycosis with a focus on Aspergillus spp. in Albania

Fida,

Prendushi,

Gjylameti

et al. 2023

Int J Dermatology

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“…in human pathologies. In this context, some Aspergillus section Circumdati species, including A. melleus, A. ochraceus, A. persii, and A. sclerotiorum, were described as causal agents of onychomycosis [40]. All of these species contain only a short fragment of the OTA cluster in their genomes, and adaptation to this unusual habitat might be related to the loss of their ability to produce the toxin because it does not have a useful function.…”

Section: Discussionmentioning

confidence: 99%

The Genomic Regions That Contain Ochratoxin A Biosynthetic Genes Widely Differ in Aspergillus Section Circumdati Species

Gil-Serna

Vázquez

Patiño

2020

Toxins

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Aspergillus section Circumdati includes 27 species, some of which are considered ochratoxin A (OTA) producers. However, there is considerable controversy about their potential OTA synthesis ability. In this work, the complete genomes of 13 species of Aspergillus section Circumdati were analyzed in order to study the cluster of OTA biosynthetic genes and the region was compared to those previously reported in A. steynii and A. westerdijkiae. The results obtained reveal that the genomes of some species in this section, including A. affinis, A. cretensis, A. elegans, A. muricatus, A. pulvericola, A. roseoglobulosus, and A. subramanianii, contain a potentially functional OTA biosynthetic cluster. Therefore, they might be able to synthesize the toxin. On the contrary, A. melleus, A. ochraceus, A. ostianus, A. persii, A. sclerotiorum, A. sesamicola, and A. westlandensis contain a truncated version of the cluster that lacks many of the genes involved in OTA biosynthesis, which might be related to their inability to produce OTA. The gain/loss pattern is different in all species, which suggests that the genetic evolution of this region might be due to independent events.

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Onychomycosis Due to Aspergillus spp.: a Current Review

Cited by 2 publications

References 54 publications

A 5‐year single‐center study about onychomycosis with a focus on Aspergillus spp. in Albania

A 5‐year single‐center study about onychomycosis with a focus on Aspergillus spp. in Albania

The Genomic Regions That Contain Ochratoxin A Biosynthetic Genes Widely Differ in Aspergillus Section Circumdati Species

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