Onychomycosis in Children with Down Syndrome

Castellanos, Jade; Toledo-Bahena, Mirna; Mena-Cedillos, Carlos; Ramirez-Cortes, Erika; Valencia, Adriana

doi:10.1007/s12281-018-0331-z

Curr Fungal Infect Rep

2018

DOI: 10.1007/s12281-018-0331-z

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Onychomycosis in Children with Down Syndrome

Jade Castellanos

Mirna Toledo-Bahena

Carlos Mena-Cedillos

et al.

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2024

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Cited by 1 publication

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Pediatric dermatophyte onychomycosis: a review

Gupta,

Taylor

2024

Int J Dermatology

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Recent studies have reported an increase in pediatric onychomycosis prevalence worldwide, suggesting that this population may be increasingly affected by the infection. A summary of the epidemiological impact, antifungal treatment options, special considerations for at‐risk subpopulations, and methods to prevent infection and recurrence are discussed. A systematic review of available epidemiological studies found the worldwide prevalence of culture‐confirmed pediatric toenail onychomycosis to be 0.33%, with no significant increases in prevalence over time. A systematic review of studies investigating the efficacy of various antifungals in treating pediatric onychomycosis found high cure rates and low frequency of adverse events with systemic itraconazole and terbinafine; however, the studies are few, dated, and lack impact because of small sample sizes. Comparatively, clinical trials implementing FDA‐approved topical antifungal treatments report slightly reduced cure rates with larger sample sizes. Patients with immunity‐altering conditions, such as Down's syndrome, or those immunosuppressed because of chemotherapy or HIV/AIDS are at a greater risk of onychomycosis infection and require special consideration with treatment. Proper sanitization and hygiene practices are necessary to reduce the risk of acquiring infection. Early diagnosis and treatment of onychomycosis in children, as well as any affected close contacts, are crucial in reducing the impact of the disease.

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Pediatric dermatophyte onychomycosis: a review

Gupta,

Taylor

2024

Int J Dermatology

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Onychomycosis in Children with Down Syndrome

Cited by 1 publication

References 41 publications

Pediatric dermatophyte onychomycosis: a review

Pediatric dermatophyte onychomycosis: a review

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