Onychomykose – ein Update

Nenoff, P.; Ginter‐Hanselmayer, Gabriele; Hj, Tietz

doi:10.1007/s00105-011-2251-5

Cited by 39 publications

(8 citation statements)

References 46 publications

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“…However, despite the high sensitivity of these techniques, false-positive or falsenegative results were observed. For this reason, other authors such as Nenoff et al (2012) have advocated a combination of conventional and molecular procedures to increase the sensitivity and specificity of the diagnosis of dermatophytosis. Direct examination of samples for fungal elements can be carried out by conventional microscopy with white light.…”

Section: Discussionmentioning

confidence: 98%

Diagnosis of dermatophytosis: an evaluation of direct examination using MycetColor® and MycetFluo®

Pihet

Clément

Kauffmann‐Lacroix

et al. 2015

Diagnostic Microbiology and Infectious Disease

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Dermatophytes are an important cause of superficial fungal infection. Direct examination of skin, nail, or hair samples remains essential in diagnosis, as it provides a quick response to the clinician. However, mycological analysis, including direct examination and culture, often lacks sensitivity. The use of stains or fluorochromes may enhance the performance of direct examination. We analyzed 102 samples from patients with suspected dermatophytosis in 4 different diagnostic mycology laboratories. Two reagents, MycetColor® and MycetFluo®, which use Congo red and calcofluor dye, respectively, were evaluated for the direct microscopic examination of skin, hair, and nail specimens. The results were compared to those of culture and conventional direct examination. Both reagents were able to clarify the specimens and also to specifically stain fungal elements. Microscopic examination of the specimens was greatly facilitated with MycetFluo®, which allowed a higher number of positive cases to be detected compared to the other methods.

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Section: Discussionmentioning

confidence: 98%

Diagnosis of dermatophytosis: an evaluation of direct examination using MycetColor® and MycetFluo®

Pihet

Clément

Kauffmann‐Lacroix

et al. 2015

Diagnostic Microbiology and Infectious Disease

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“…All these data are in accordance with the literature. 17,18 The most common clinical type in both hands and feet was distal subungual onychomycosis, followed by white superficial and total, respectively. Based on the extent of nail involvement, onychomycosis was defined as moderate/severe (>50% of lamina involvement and/ or matrix involvement) in 74.1% of the cases.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of onychomycosis in Italy: prevalence data and risk factor identification

Papini

Piraccini

Difonzo

et al. 2015

Mycoses

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The prevalence of onychomycosis differs according to geographic area and over time and is influenced by several factors. The epidemiology of onychomycosis in Italy is still unclear. To evaluate the prevalence of onychomycosis in a representative sample of the Italian population a group of Dermatologists and General Practitioners carried out an observational survey on the patients coming to their office during a 1-month period. Any patient with skin or systemic disease giving their consent was enrolled. Demographic characteristics, comorbidities, lifestyles, history of previous mycosis, clinical aspects of onychomycosis and mycological evaluation were studied. A total of 8331 patients (56.7% female and 43.3% male) were evaluated. More than half of them were aged ≥46 years. Onychomycosis was diagnosed in 14.2% of patients. Big toe and thumb were the most frequently affected nails. Onychomycosis was moderate-severe in 74.1% of the cases. Mycological tests were positive in 81.3% of the cases. Dermatophytes were found in 76.6% of the cases, yeasts in 17.2% and moulds in 6.3%. Risk factors and/or comorbidities were present in 68.2% of the cases. This survey showed a 14% prevalence of onychomycosis in the evaluated population. The main risk factors were previous onychomycosis, diabetes, hallux valgus and use of occlusive footwear.

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“…25,26 This may be explained by increasing use of swimming pools, growing involvement in sports, wearing of occlusive footwear both in professional settings and during leisure time, and increasing incidence of diabetes and vascular disease. 8,27,28 …”

Section: Discussionmentioning

confidence: 99%

Clinical, epidemiological, and therapeutic profile of dermatophytosis

Pires

Cruz

Lobato

et al. 2014

An. Bras. Dermatol.

104

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BACKGROUNDThe cutaneous mycoses, mainly caused by dermatophyte fungi, are among the most common fungal infections worldwide. It is estimated that 10% to 15% of the population will be infected by a dermatophyte at some point in their lives, thus making this a group of diseases with great public health importance.OBJECTIVETo analyze the clinical, epidemiological, and therapeutic profile of dermatophytosis in patients enrolled at the Dermatology service of Universidade do Estado do Pará, Brazil, from July 2010 to September 2012.METHODA total of 145 medical records of patients diagnosed with dermatophytosis were surveyed. Data were collected and subsequently recorded according to a protocol developed by the researchers. This protocol consisted of information regarding epidemiological and clinical aspects of the disease and the therapy employed.RESULTSThe main clinical form of dermatophyte infection was onychomycosis, followed by tinea corporis, tinea pedis, and tinea capitis. Furthermore, the female population and the age group of 51 to 60 years were the most affected. Regarding therapy, there was a preference for treatments that combine topical and systemic drugs, and the most widely used drugs were fluconazole (systemic) and ciclopirox olamine (topical).CONCLUSIONThis study showed the importance of recurrent analysis of the epidemiological profile of dermatophytosis to enable correct therapeutic and preventive management of these conditions, which have significant clinical consequences, with chronic, difficult-totreat lesions that can decrease patient quality of life and cause disfigurement.

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Onychomykose – ein Update

Cited by 39 publications

References 46 publications

Diagnosis of dermatophytosis: an evaluation of direct examination using MycetColor® and MycetFluo®

Diagnosis of dermatophytosis: an evaluation of direct examination using MycetColor® and MycetFluo®

Epidemiology of onychomycosis in Italy: prevalence data and risk factor identification

Clinical, epidemiological, and therapeutic profile of dermatophytosis

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