Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility

Ahmed, Toka A.; Ahmed, Sara Atito Ali; El-Gammal, Zaynab; Shouman, Shaimaa; Ahmed, Ashrakat; Mansour, Ragaa; El‐Badri, Nagwa

doi:10.1007/5584_2019_456

Cited by 66 publications

(51 citation statements)

References 132 publications

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“…In the light of these study findings, some environmental factors associated with female fertility should be considered, as they can potentially influence cognitive abilities and, as a result, impair women’s reproductive systems. Of the utmost importance are those that affect human oocyte quality and function, and contribute to accelerated oocyte aging and female infertility [ 5 ]. These include a high-fat diet, as obesity can lead to anovulation, polycystic ovarian syndrome, or pregnancy complications [ 110 ].…”

Section: Discussionmentioning

confidence: 99%

“…These include a high-fat diet, as obesity can lead to anovulation, polycystic ovarian syndrome, or pregnancy complications [ 110 ]. Poor diet can also lead to insulin resistance and the resulting hyperinsulinemia, which can facilitate ovulatory dysfunction and infertility [ 5 , 111 ]. Environmental pollution factors are of no less importance.…”

Section: Discussionmentioning

confidence: 99%

“…The probability of conception occurring outside the fertile window is virtually zero [ 4 ]. Female fertility is highly dependent on age, and the decrease in fertility accelerates after the age of 35 due to reductions in the ovarian reserve and oocyte quality [ 5 ]. Human oocyte aging is also affected by various behavioral factors, such as dietary habits and lifestyle [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Female fertility is highly dependent on age, and the decrease in fertility accelerates after the age of 35 due to reductions in the ovarian reserve and oocyte quality [ 5 ]. Human oocyte aging is also affected by various behavioral factors, such as dietary habits and lifestyle [ 5 ]. Also of importance are environmental factors such as air pollution [ 6 ] or pesticides (e.g., Mancozeb), which have been shown to interfere with female sex hormones and cause disruption of the ovarian cycle [ 3 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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The More Fertile, the More Creative: Changes in Women’s Creative Potential across the Ovulatory Cycle

Galasinska

Szymków

2021

IJERPH

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Creative thinking is a defining human feature. It provides novel solutions and as such undoubtedly has contributed to our survival. However, according to signaling theory, creativity could also have evolved through sexual selection as a potential fitness indicator. In our study, we tested one implication of this theory. Specifically, we hypothesized that if creativity can serve as a signal of women’s fitness, then we should observe an increase in creative thinking in the fertile phase of the ovulatory cycle compared to other non-fertile phases. In our study (N = 751), we tested creative potential throughout the ovulatory cycle. We found a positive correlation between the probability of conception and both creative originality and flexibility. Importantly, we also tested the mediating role of arousal in the relationship between the probability of conception and creative thinking. The results of our study are discussed in terms of signaling theory, through which women advertise their fitness with their creativity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The More Fertile, the More Creative: Changes in Women’s Creative Potential across the Ovulatory Cycle

Galasinska

Szymków

2021

IJERPH

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“…The decline in fertility in women aged 30-35 years is slow and steady; however, the decline accelerates after the age of 35 years due to decreases in the ovarian reserve and oocyte quality. 41 The subgroup analysis will assess the impact of COVID-19 on the fertility of women aged <35 years and >35 years.…”

Section: Ethics and Disseminationmentioning

confidence: 99%

Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol

Zhang

et al. 2021

BMJ Open

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IntroductionThe increased social and economic burden caused by the novel COVID-19 outbreak is gradually becoming a worrisome issue for the health sector. The novel coronavirus invades the target cell by binding to ACE2, which is widely expressed in the ovaries, uterus, vagina and placenta. Significantly, the SARS-CoV-2 is said to interrupt female fertility through regulating ACE2. Thus, it is essential to investigate if the novel COVID-19 hampers female fertility, given that there is no systematic and comprehensive evidence on the association of COVID-19 with female fertility.Methods and analysisWe will systematically search cohort studies, cross-sectional studies, case–control studies and self-controlled case series designs in the following databases: Web of Science, PubMed, EMBASE, Cochrane Library, Ovid, EBSCO, WHO COVID-19 Database, Chinese Biomedical Databases, China National Knowledge Internet, VIP and WanFang Database. Medical Subject Headings and free-text terms for “COVID-19” AND “female” AND “fertility” will be performed. Eligibility criteria are as follows: population (female patients aged 13–49 years); exposure (infection with SARS-CoV-2); comparison (population without SARS-CoV-2 infections or latent SARS-CoV-2 infections); and outcome (female fertility, such as ovarian reserve function, uterine receptivity, oviducts status and menstruation status). Article screening and data extraction will be undertaken independently by two reviewers, and discrepancies will be resolved through discussion. We will use the I2 statistics to assess the heterogeneity and perform a meta-analysis when sufficiently homogeneous studies are provided. Otherwise, a narrative synthesis will be performed. We will explore the potential sources of heterogeneity using subgroup analyses and meta-regression.Ethics and disseminationFormal ethical approval is not required, and findings will be published in a peer-reviewed journal.PROSPERO registration numberCRD42020189856.

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Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis ofGC‐1 spg cells induced byH₂O₂

Dong

Yang

et al. 2022

Environmental Toxicology

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C-phycocyanin (C-PC) is an effective antioxidant and has an important value in medical research. Oxidative stress is considered to be one of the main underlying mechanisms of cell death, and reducing oxidative stress is one of the strategies to enhance germ cell viability. Herein, we investigated the protective effect and the mechanism of C-PC and apo-phycocyanin subunit on oxidative stress damage induced by H 2 O 2 in GC-1 spg cells. C-PC genes were cloned into the pGEX-4T-1 vectorand transformed into Escherichia coli BL21 to achieve the efficient expression of C-PC subunit.GC-1 spg cells were treated with 600 μM H 2 O 2 for 24 h to establish the oxidative stress damage model. Cell viability was detected by CCK-8. The degree of oxidative stress was detected by testing Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and glutathione (GSH) and Malondialdehyde (MDA) levels. Reactive oxygen species (ROS) was evaluated utilizingby 2', 7'-dichlorofluorescentdiacetate (DCFH-DA). Mitochondrial membrane potential was determined by JC-1.Cell necrosis rate was detected by Annexin V-FITC/PI. Expression of protein was detected by western blot. We found that C-PC and GST-CPC β significantly inhibited H 2 O 2 -induced oxidative damage of GC-1 spg cells, improved the ability of antioxidation, reduced ROS overproduction, and mitochondrial membrane potential loss, and inhibited the RIP-1/RIP-3/ p-MLKL signaling pathway to reduce the necrosis rate. The results demonstrated that C-PC played a protective role against H 2 O 2induced cell damage, especially its β subunit. This study provides a theoretical basis for C-PC as a potential protective agent of reproductive system.

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Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility

Cited by 66 publications

References 132 publications

The More Fertile, the More Creative: Changes in Women’s Creative Potential across the Ovulatory Cycle

The More Fertile, the More Creative: Changes in Women’s Creative Potential across the Ovulatory Cycle

Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol

Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis ofGC‐1 spg cells induced byH₂O₂

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Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility

Cited by 66 publications

References 132 publications

The More Fertile, the More Creative: Changes in Women’s Creative Potential across the Ovulatory Cycle

The More Fertile, the More Creative: Changes in Women’s Creative Potential across the Ovulatory Cycle

Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol

Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis ofGC‐1 spg cells induced byH2O2

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Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis ofGC‐1 spg cells induced byH₂O₂