Oocyte Cryopreservation for Fertility Preservation in Postpubertal Female Children at Risk for Premature Ovarian Failure Due to Accelerated Follicle Loss in Turner Syndrome or Cancer Treatments

Oktay, Kutluk; Bedoschi, Giuliano

doi:10.1016/j.jpag.2014.01.003

Cited by 80 publications

(72 citation statements)

References 26 publications

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“…Attempts have been made by the freezing of ovarian cortical tissue for young adolescent girls or by the collection of stimulated mature oocytes as part of an IVF cycle for older girls; however, due to the restricted oocyte number, these techniques are not routine and have had to date limited success (150) but may offer promise in the future (242). Furthermore, when a woman with Turner syndrome commences fertility treatment in view of the associated increased risk of cardiovascular-related mortality in pregnancy, they should be cared for under specialized care, and indeed, Turner syndrome should be considered a relative contraindication to pregnancy (266).…”

Section: Geneticmentioning

confidence: 99%

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Hart

2016

Physiological Reviews

174

119

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Across the Western World there is an increasing trend to postpone childbearing. Consequently, the negative influence of age on oocyte quality may lead to a difficulty in conceiving for many couples. Furthermore, lifestyle factors may exacerbate a couple's difficulty in conceiving due mainly to the metabolic influence of obesity; however, the negative impacts of low peripheral body fat, excessive exercise, the increasing prevalence of sexually transmitted diseases, and smoking all have significant negative effects on fertility. Other factors that impede conception are the perceived increasing prevalence of the polycystic ovary syndrome, which is further exacerbated by obesity, and the presence of uterine fibroids and endometriosis (a progressive pelvic inflammatory disorder) which are more prevalent in older women. A tendency for an earlier sexual debut and to have more sexual partners has led to an increase in sexually transmitted diseases. In addition, there are several genetic influences that may limit the number of oocytes within the ovary; consequently, by postponing attempts at childbearing, a limitation of oocyte number may become evident, whereas in previous generations with earlier conception this potentially reduced reproductive life span did not manifest in infertility. Environmental influences on reproduction are under increasing scrutiny. Although firm evidence is lacking however, dioxin exposure may be linked to endometriosis, phthalate exposure may influence ovarian reserve, and bisphenol A may interfere with oocyte development and maturation. However, chemotherapy or radiotherapy is recognized to lead to ovarian damage and predispose the woman to ovarian failure.

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Section: Geneticmentioning

confidence: 99%

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Hart

2016

Physiological Reviews

174

119

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“…В последние годы в медицинской литературе большое внимание уделяется медико-социаль-ным факторам формирования репродуктивно-го здоровья у девушек-подростков как будущих матерей [16,17,18,19,20].…”

Section: Discussionunclassified

Reproductive Health of Preterm-Born Adolescent Girls

Nikulina¹,

Елгина²,

Ушакова³

2017

FCM

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РезюмеЦель. Оценка состояния репродуктивной системы девушек-подростков, рожденных до-ношенными и недоношенными при сроке бере-менности 28-32 недели (физического развития, менструальной функции, размеров таза, основ-ных ультразвуковых параметров матки и при-датков).Материалы и методы. Девочки-подрост-ки 15-16 лет, рожденные доношенными и не-доношенными при сроке беременности 28-32 недели (соответственно 100 и 29), исследо-ваны общеклиническим, гинекологическим, инструментальным, ультразвуковым метода-ми.Результаты. Определены показатели ре-продуктивной системы девушек-подростков, рожденных доношенными и недоношенными (физического развития, менструальной функ-ции, размеров таза, основных ультразвуковых параметров матки и придатков). Установлены статистически значимые различия основных показателей, характеризующих репродуктив-ную системы у девушек-подростков, рожден-ных недоношенными, по отношению к рожден-ным доношенными, а именно, менструальной функции, размеров таза, ультразвуковых пара-метров матки и придатков.Заключение. Невынашивание беременно-сти вносит изменение в формирование станов-ления репродуктивной системы в постнаталь-ном периоде и способствует возникновению ее патологии.Ключевые слова: девушки-подростки, рожденные доношенными и недоношенными, показатели репродуктивной системы. AbstractAim. To assess the reproductive health of preterm-and full-term-born adolescent girls with a gestational age of 28-32 weeks.Materials and Methods. We recruited 100 consecutive full-term-born adolescent girls (15-16 years of age) and 29 preterm-born (gestational age of 28-32 weeks) and performed a clinical and gynecological examination. Results.We identified the parameters of physical development, menstrual function, pelvic size, and the main ultrasound parameters of the uterus and uterine appendages. Preterm-born adolescent girls more frequently had extended menstrual cycle, less pelvic, ovarian, and uterine size, less endometrial thickness, and longer cervix.Conclusion. Preterm birth affects the development of the reproductive system in English

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“…Oktay et al have reported on successful oocyte cryopreservation in post-pubertal children with mosaic TS 25,26 . In these reports, three girls aged 13–15 with mosaic TS were identified to have decreased ovarian reserve by serum AMH hormone measurements and antral follicle counts on ultrasound examinations.…”

Section: Fertility Preservation Strategiesmentioning

confidence: 99%

“…Because the ovarian reserve can be lost even during the very first few years of life in full TS cases, ovarian tissue cryopreservation may be the only, albeit experimental, option for this population. While ovarian reserve evaluation may be difficult in children under the age of 5 20 , a combination of serum FSH, Inhibin-B, AMH and antral follicle counts on ultrasound may provide useful information 23,25 .…”

Section: Fertility Preservation Strategiesmentioning

confidence: 99%

Fertility Preservation in Women with Turner Syndrome: A Comprehensive Review and Practical Guidelines

Oktay

Bedoschi

Berkowitz

et al. 2016

Journal of Pediatric and Adolescent Gynecology

162

129

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This article reviews the existing fertility preservation options for females diagnosed with Turner syndrome and provides practical guidelines for the practitioner. Turner syndrome is the most common sex chromosome abnormality in females, occurring in approximately one in 2500 live births. Women with Turner syndrome are at extremely high risk for primary ovarian insufficiency (POI) and infertility. Although about 70–80% have no spontaneous pubertal development and 90% experience primary amenorrhea, the remainder may possess a small residual of ovarian follicles at birth or early childhood. The present challenge is to identify these women as early in life as is possible, so as to allow them to benefit from a variety of existing fertility preservation options. To maximize the benefits of fertility preservation, all women with Turner syndrome should be evaluated by an expert as soon as possible in childhood as the vast majority will have their ovarian reserve depleted before adulthood. Cryopreservation of mature oocytes and embryos is a proven fertility preservation approach, while cryopreservation of ovarian tissue is a promising technique with a growing number of live births, but remain investigational. Oocyte cryopreservation has been performed in children with Turner syndrome as young as 13 and ovarian tissue cryopreservation in prepubertal children affected. However, current efficacy of these approaches is unknown in this cohort.. For those who have already lost their ovarian reserve, oocyte or embryo donation and adoption are strategies that allow fulfillment of desire for parenting. For those with Turner syndrome related cardiac contraindications to pregnancy, utilization of gestational surrogacy allows the possibility of biological parenting by using their own oocytes. Alternatively, gestational surrogacy can serve to carry pregnancy resulting from the use of donor oocytes or embryos, if needed.

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Oocyte Cryopreservation for Fertility Preservation in Postpubertal Female Children at Risk for Premature Ovarian Failure Due to Accelerated Follicle Loss in Turner Syndrome or Cancer Treatments

Cited by 80 publications

References 26 publications

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Reproductive Health of Preterm-Born Adolescent Girls

Fertility Preservation in Women with Turner Syndrome: A Comprehensive Review and Practical Guidelines

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