Oocyte donation recipients of very advanced age: perinatal complications for singletons and twins

Guesdon, Elodie; Vincent-Rohfritsch, A.; Bydlowski, Sarah; Santulli, Piétro; Goffinet, François; Ray, Camille Le

doi:10.1016/j.fertnstert.2016.09.021

Cited by 23 publications

(31 citation statements)

References 49 publications

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“…The authors recommended elective single ET in these women 68 69 70 . Therefore, in addition to age, there is a need for guidelines regarding the number of embryos to be transferred in these couples 70 . The complications of pregnancy increase many folds in case of multiple pregnancies.…”

Section: Higher Maternal Morbidity and Mortalitymentioning

confidence: 99%

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Mid-life fertility

Jindal¹

2018

Indian Journal of Medical Research

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This review highlights the challenges, priority areas of research and planning, strategies for regulation of services and the need to develop guidelines and laws for fertility treatments during mid-life. The success rate of all treatments is poor in advanced age women because of declining ovarian reserve and natural fertility. There is often a need of third-party involvement which has its own ethical, legal and medical issues. Welfare of children born to older women and early death of parents are important concerns. Most of the new techniques such as the pre-implantation genetic diagnosis, oocyte augmentation, use of stem cells or artificial gametes, ovarian tissue preservation and ovarian transplantation are directed to improve, preserve or replace the declining ovarian reserve. These techniques are costly and have limited availability, safety and efficacy data. Continued research and policies are required to keep pace with these techniques. The other important issues include the patients’ personal autonomy and right of self-determination, welfare of offspring, public vs. private funding for research and development of new technologies vs. indiscriminate use of unproven technology. It is important that mid-life fertility is recognized as a distinct area of human reproduction requiring special considerations.

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Section: Higher Maternal Morbidity and Mortalitymentioning

confidence: 99%

“…The complications of pregnancy increase many folds in case of multiple pregnancies. This guideline becomes very pertinent in relation to ovum donation cycles to protect these women against the additional burden of multiple pregnancy 67 70 .…”

Section: Higher Maternal Morbidity and Mortalitymentioning

confidence: 99%

Mid-life fertility

Jindal¹

2018

Indian Journal of Medical Research

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“…Guedson et al 4 also looked into twin gestations in particular, and found no statistically significant difference in the outcome of the 2age groups. But as accepted twin pregnancies had a much higher complication rate as compared to singleton pregnancies, having higher incidence of preterm premature rupture of membranes, babies having lower birth weight along with deliveries occurring at an earlier gestation age.…”

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confidence: 97%

“…Is the maternal and neonatal risk strong enough to warrant gestational surrogacy instead of oocyte donation pregnancy. Guesdon E et al 4 gave an experience from a single obstetric unit in France having deliveries over the age of 45-49 and over 50years .They examined 40 deliveries in women over 50 and 146 deliveries in women between 45-49 following oocyte donation. Since all deliveries took place in a single centre, chances of greater similarity in mode of obstetric treatment among all cases, which allows for a better differentiation of the effect of age in this elderly age group.…”

mentioning

confidence: 99%

“…No maternal deaths were reported. Post partum haeomorrhage incidence was high which lead to unusually high number of emergency hysterectomies, i.e 4 but it was thought by Guedson et al 4 that the advanced age of the patients might have resulted in this decision of performing a hysterectomy versus more conservative procedure. 2 Obstetric complications were relatively high in the group as a whole, although little differences were noted in the 2 age groups.…”

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confidence: 99%

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Maternal and fetal complications following oocyte donation to women over 50: is it safe

Kaur¹

2018

MOJCSR

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Maternal age and pregnancy outcomes in twin compared with singleton gestations

Hiersch

Berger

McDonald

et al. 2023

Intl J Gynecology & Obste

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Objective To estimate the association of advanced maternal age with pregnancy complications in twin pregnancies and compare it with that observed in singleton pregnancies. Methods A population‐based retrospective cohort study of all patients with a singleton or twin hospital birth in Ontario, Canada, between 2012 and 2019. The primary outcome was preterm birth (PTB) less than 34 weeks. Pregnancy outcomes were stratified by maternal age groups in twin pregnancies and, separately, in singleton pregnancies. Results A total of 935 378 patients met the study criteria: 920503 (98.4%) had a singleton pregnancy and 14 875 (1.6%) had twins. In singletons, the rate of PTB less than 34 weeks increased progressively with increasing maternal age and was highest for patients aged 45 years or more (3.4%; adjusted risk ratio [aRR] 1.56, 95% confidence interval [CI] 1.05–2.33). By contrast, in twins, although the rate of PTB less than 34 was highest patients under 20 years of age (25.3%) and was lowest among patients aged 35–39 years (11.7%), the associations between maternal age group and the risk of PTB were not statistically significant in the adjusted analysis. Conclusion Although the absolute rates of pregnancy complications are higher in twin pregnancies, there are considerable differences in the relationship between maternal age and the risk of certain complications between twin and singleton pregnancies.

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Oocyte donation recipients of very advanced age: perinatal complications for singletons and twins

Abstract: Complication rates were similar among women aged 50 years and older and those aged 45-49 years. Nonetheless, given the high rate of complication in both groups, especially among twin pregnancies, single embryo transfer needs to be encouraged for oocyte donations after age 45 years.

Cited by 23 publications

References 49 publications

Mid-life fertility

Mid-life fertility

Maternal and fetal complications following oocyte donation to women over 50: is it safe

Maternal age and pregnancy outcomes in twin compared with singleton gestations

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