Oocyte donation treats infertility in survivors of malignancies

Donor oocyte conception and pregnancy complications: a systematic review and meta‐analysis

“…Our meta‐analysis showed that the chances of caesarean delivery for singletons are significantly higher with DO pregnancy. Similar findings are reported by other authors …”

“…2 In addition to advanced maternal age there are various other indications for DO conception, which include primary or secondary ovarian failure, diminished ovarian reserve, multiple failures of in vitro fertilisation (IVF), and diagnoses of genetic conditions. 3 The treatment option of egg sharing, which involves a woman sharing her eggs with another in exchange for free or reduced-cost fertility treatment, has been regulated in the UK since 1998, and is viewed positively by the egg-sharing donors and recipients. 4 Advanced maternal age in itself is associated with pregnancy complications, including hypertensive disorders, gestational diabetes, preterm labour, and intrauterine growth restriction.…”

Endometrial receptivity after oocyte donation in recipients with a history of chemotherapy and/or radiotherapy

“…The largest available study on this subject evaluated the outcome of OD and pregnancy among 24 women (40 cycles) who had survived a malignancy and reported a clinical pregnancy rate of 42.5% with a spontaneous abortion rate of 11.8% (Kavic et al, 2001). No comparison was made with their general population of oocyte recipients and no details were available on the type of radiotherapy the patients were exposed to.…”

“…However, only very few data based on case reports are available in the literature on the outcome of OD cycles in this particular subgroup of oocyte recipients. Most published reports show that OD is feasible but is associated with a lower pregnancy rate than that expected in the general population of oocyte recipients (Pados et al, 1992;Sauer et al, 1994;Remohi et al, 1997;Anselmo et al, 2001;Kavic et al, 2001). However, two other reports, also based on a limited number of patients, showed no difference in pregnancy rate in cancer survivors (Paulson et al, 1997;Moomjy et al, 1999).…”

High risks of maternal and perinatal complications in singletons born after oocyte donation

“…The first successful pregnancy after oocyte donation (OD) was reported in 1984 and since then OD has given many women with ovarian failure or dysfunction the opportunity to experience biological parenthood. At first, OD was indicated for premature ovarian insufficiency but the indications were expanded to include cases of advanced maternal age, diminished ovarian reserve, infertility after treatment for malignancies and women with multiple experiences of failed in vitro fertilization (IVF) attempts . OD has now become well‐established, with thousands of children born totally worldwide as a result of OD.…”