Oocyte in vitro maturation: A sytematic review

Hatırnaz, Şafak; Ata, Barış; Hatırnaz, Ebru; Dahan, Michael H.; Tannus, Samer; Tan, Justin; Tan, Seang Lin

doi:10.4274/tjod.23911

Cited by 77 publications

(71 citation statements)

References 139 publications

(173 reference statements)

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“…In IVM procedures, oocytes are retrieved from small and intermediate sized follicles when the largest of the cohort has not yet surpassed 13 mm in diameter. These cumulus-enclosed oocytes are then matured in vitro prior to insemination by small dosage gonadotropin, with or without hCG [ 215 , 216 ].…”

Section: Non-male Factor Indications Of Icsimentioning

confidence: 99%

Thoughts on the popularity of ICSI

Haddad

Stewart

Xie

et al. 2020

J Assist Reprod Genet

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Purpose Intracytoplasmic sperm injection (ICSI) is the most widely utilized assisted reproductive technique (ART) worldwide. In this feature, we review the early assisted fertilization attempts that eventually led to the development of ICSI, and discuss its current utilization in cases of male and non-male factor infertility. Methods We researched the literature related to the development, indications, and current use of ICSI, such as sperm structural abnormalities, male genetic indications, surgically retrieved sperm, high sperm chromatin fragmentation, oocyte dysmorphism, and preimplantation genetic testing (PGT). We also describe the potential future applications of ICSI. Results This review summarizes the early micromanipulation techniques that led to the inception of ICSI. We also explore its current indications, including non-male factor infertility, where its use is more controversial. Finally, we consider the benefits of future advancements in reproductive biology that may incorporate ICSI, such as in vitro spermatogenesis, neogametogenesis, and heritable genome editing. Conclusion The versatility, consistency, and reliability of ICSI have made it the most prevalently utilized ART procedure worldwide.

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Section: Non-male Factor Indications Of Icsimentioning

confidence: 99%

Thoughts on the popularity of ICSI

Haddad

Stewart

Xie

et al. 2020

J Assist Reprod Genet

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“…To this end, immature germinal vesicle (GV; at the PI stage of first meiosis) oocytes are recovered from growing small follicles less than 14 mm in diameter following stimulated with rFSH or its analogs (Junk & Yeap, 2012). Then, GV oocytes undergo nuclear and cytoplasmic maturation to produce MII oocytes during routine IVM procedure (Hatirnaz et al, 2018). After obtaining MII oocytes from either conventional ARTs or IVM, the cumulus cells surrounding these oocytes can be removed by gentle pipetting to readily manipulate denuded oocytes during intracytoplasmic sperm injection (ICSI) application.…”

Section: Introductionmentioning

confidence: 99%

Selection of competent oocytes by morphological criteria for assisted reproductive technologies

Öztürk

2020

Molecular Reproduction Devel

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Invasive and noninvasive methods are commonly used to select developmentally competent oocytes that can improve the take-home baby rates in assisted reproductive technology (ART) centers. One of the noninvasive methods conventionally utilized to determine competent oocytes is the morphological analysis of cumulus complex, first polar body, zona pellucida, perivitelline space, meiotic spindle, and ooplasm. Successful fertilization, early embryo development, uterine implantation, and healthy pregnancy depend on the quality of oocytes, and morphological evaluation is one of the options used to predict quality levels. In this review, the morphological criteria being utilized in certain ART centers are comprehensively evaluated with special references to their predictive values and potential contributions to selecting high-quality oocytes.

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“…For example, this technique requires no or little gonadotropin supplementation in vivo , which can significantly reduce ovarian hyperstimulation syndrome risk, medical expenses and drug-related side effects [ 5 , 6 ]. Despite the great advances in oocyte IVM technique, there are still a lot of controversial issues that need to be addressed [ 7 ]. An in-depth understanding on cellular and molecular basis of oocyte IVM contributes to fertility protection, pregnancy rate improvement and the better management of ovarian hyperstimulation syndrome and infertility.…”

Section: Introductionmentioning

confidence: 99%

UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression

et al. 2020

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Oocyte maturation is a prerequisite for successful fertilization and embryo development. Incomplete oocyte maturation can result in infertility. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) has been found to be implicated in oocyte maturation and embryo development. However, the cellular and molecular mechanisms of UCH-L1 underlying oocyte maturation have not been fully elucidated. In the present study, we observed that the introduction of UCH-L1 inhibitor LDN-57444 suppressed first polar body extrusion during mouse oocyte maturation. The inhibition of UCH-L1 by LDN-57444 led to the notable increase of reactive oxygen species (ROS) level, conspicuous reduction of glutathione (GSH) content and mitochondrial membrane potential (MMP), and blockade of spindle body formation. As a conclusion, UCH-L1 inhibitor LDN-57444 suppressed mouse oocyte maturation by improving oxidative stress, attenuating mitochondrial function, curbing spindle body formation and down-regulating ERK1/2 expression, providing a deep insight into the cellular and molecular basis of UCH-L1 during mouse oocyte maturation.

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Oocyte in vitro maturation: A sytematic review

Cited by 77 publications

References 139 publications

Thoughts on the popularity of ICSI

Thoughts on the popularity of ICSI

Selection of competent oocytes by morphological criteria for assisted reproductive technologies

UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression

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