Oocyte or embryo number needed to optimize live birth and cumulative live birth rates in mild stimulation IVF cycles

Datta, Adrija; Campbell, Stuart; Felix, Nirmal; Singh, Jasdev Singh Harbhajan; Nargund, Geeta

doi:10.1016/j.rbmo.2021.02.010

Cited by 20 publications

(16 citation statements)

References 46 publications

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“…Notably, however, oocyte quantity can also be used as an independent predictor of oocyte quality and live-birth rate. Some reports showed that women with higher numbers of retrieved oocytes have a higher pregnancy rate and live-birth rate [ 27 , 28 , 29 ]. It has also been shown that oocyte quantity and oocyte quality have a significant impact on the cumulative live-birth rate [ 30 ] and that oocyte number and number of top/good-quality embryos are positively correlated [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

Chen

Lin

et al. 2021

JCM

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Serum vascular endothelial growth factor (VEGF) is involved in follicular vascularization, oxygenation, and consequently in oocyte maturation and embryo development. Unanswered questions remain regarding the relationship of intrafollicular VEGF level in preovulatory leading follicles to oocyte maturation and ovarian reserve during ovarian stimulation. We conducted this study to investigate the relationship of intrafollicular VEGF level in the fluid of single preovulatory leading follicles to ovarian reserve and oocyte maturation in patients receiving GnRH antagonist in vitro fertilization (IVF) protocol treatment. One hundred and eighty-five patients receiving IVF treatment were recruited and assigned to low-, normal-, and high-ovarian-reserve groups according to their serum anti-Müllerian hormone (AMH) level. Follicular fluid (FF) in preovulatory leading follicles, serum profiles, and clinical variables were collected for analysis. The result disclosed a significant among-group difference in FF VEGF concentration. Moreover, the serum AMH level was also negatively correlated with FF VEGF level. The oocyte maturation rate tended to be increased at higher AMH levels. FF VEGF concentration was significantly positively correlated with basal FSH level. In conclusion, FF VEGF concentration has a negative association with ovarian reserve level and oocyte maturation rate in patients undergoing GnRH antagonist IVF protocols.

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Section: Introductionmentioning

confidence: 99%

VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

Chen

Lin

et al. 2021

JCM

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“…These predictors are well known to be able to impact ART success, in fact, they are commonly considered during clinical practice to estimate the couple's pregnancy chance. 29 However, this classical picture changes when fresh and frozen cycles were considered separately in our cohort. Indeed, although fresh cycle success remains TA B L E 1 Overall cohort characteristics.…”

Section: Discussionmentioning

confidence: 87%

Which sperm parameter limits could really guide the clinical decision in assisted reproduction?

et al. 2022

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Background The predictive role of sperm motility and morphology was recently detected in a large sample of more than 20000 assisted reproductive technology (ART) fresh cycles. However, the complete ART procedure consisted of both fresh and frozen‐embryos transfers and only a comprehensive evaluation of the entire process could really confirm if these parameters really predict the ART success. The aim of the study was to evaluate which sperm parameter could predict the success of ART. Methods A retrospective, real‐world data analysis was performed, enrolling all couples attending ART from 2008 to 2021, including both fresh and frozen cycles and both in vitro fertilization (IVF) and intra‐cytoplasmic sperm injection (ICSI) procedures. Results Fresh cycles success (considering live birth rate) was predicted by female age (1.04 [1.02–1.06]), injected oocytes (0.96 [0.93–0.99]), embryo number (0.79 [0.75–0.83]) and progressive sperm motility (0.98 [0.97‐0.99]). On the contrary, frozen cycle outcomes were predicted only by sperm motility (0.97 [0.95–0.99]). This prediction was confirmed in IVF but not in ICSI cycles. Conclusion Both female and male parameters predicted the ART success considering the entire path. However, frozen cycle success was predicted only by progressive sperm motility in IVF cycles, suggesting that the potential amelioration of this male parameter is relevant to improve ART success. Those couples expected to obtain the highest embryos after fertilization (low female age and better semen parameters) will have more attempts with frozen cycles and thus would benefit from a potential treatment focused to improve sperm parameters.

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“…Later, as the number of oocytes harvested increases, the live birth rate for the first transplant gradually decreases. A study showed that 9 oocytes could optimize the chance of live birth following fresh transfer in women with normal ovarian reserve ( 24 ). Retrieving at least 20 oocytes may be the optimal cutoff point for FET in order to maximize the likelihood of a successful pregnancy and live birth while minimizing complications ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

The Optimal Number of Oocytes Retrieved From PCOS Patients Receiving IVF to Obtain Associated With Maximum Cumulative Live Birth Rate and Live Birth After Fresh Embryo Transfer

et al. 2022

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AimsThis study aims to determine the optimal number of oocytes retrieved so that patients with polycystic ovary syndrome (PCOS) receiving in vitro fertilization (IVF) can obtain the best cumulative live birth rate (CLBR) and live birth after fresh embryo transfer.MethodsThis is a retrospective study of 1,419 patients with PCOS who underwent their first IVF cycle at the Second Hospital of Hebei Medical University from January 2014 to December 2021. Multivariable regression analysis was performed to adjust for factors known to independently affect cumulative live birth aspiration. The number of oocytes retrieved to obtain the best cumulative live birth rate was explored through curve fitting and threshold effect analysis. The decision tree method was used to explore the best number of oocytes retrieved to achieve live birth in the shortest time.Results(1) The number of oocytes retrieved was found to be an independent protective factor for the cumulative live birth rate (OR = 1.09 (95% CI: 1.06, 1.12)). When the number of oocytes retrieved was less than 15, CLBR increased by 16% with each increase in the number of oocytes retrieved (OR = 1.16 (95% CI: 1.11, 1.22)); and when more than 15, CLBR tended to be stable. (2) Live birth after the first fresh embryo transfer was analyzed through a classification decision tree. For patients younger than 35 years old, those with less than 6 oocytes and those with 7–16 oocytes had a similar proportion of live births with fresh embryo transfer but higher than 16 oocytes (53.7% vs. 53.8% vs. 18.4%). Patients older than 35 years old had a similar proportion of live births with fresh embryo transfer (35.7% vs. 39.0%) to those younger than 35 years old, but the proportion of no live births after using up all embryos was higher than those younger than 35 years old (39.3% vs. 19.2%).ConclusionsIn PCOS patients, high CLBR can be obtained when the number of oocytes retrieved was 15 or more. The number of oocytes retrieved from 7 to 16 could achieve more chance of live birth after fresh embryo transfer.

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Oocyte or embryo number needed to optimize live birth and cumulative live birth rates in mild stimulation IVF cycles

Cited by 20 publications

References 46 publications

VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

Which sperm parameter limits could really guide the clinical decision in assisted reproduction?

The Optimal Number of Oocytes Retrieved From PCOS Patients Receiving IVF to Obtain Associated With Maximum Cumulative Live Birth Rate and Live Birth After Fresh Embryo Transfer

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