Oocyte quality in women with thalassaemia major: insights from IVF cycles

Mensi, Laura; Borroni, Raffaella; Reschini, Marco; Cassinerio, Elena; Vegetti, Walter; Baldini, Marina; Cappellini, Maria Domenica; Somigliana, Edgardo

doi:10.1016/j.eurox.2019.100048

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…OI is the preferred ART for use in women with HH as exogenous gonadotropins can overcome central hypothalamic deficiency to stimulate functional oocytes. 13 OI has a published success rate of 80% and was successful in two women with HH. 7 OI accounted for only a third of ART utilised by our cohort.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy and assisted reproductive technology use in Australian female transfusion‐dependent haemoglobinopathy patients: a 20‐year retrospective analysis

Anderson

Perram

Nelson

et al. 2023

Internal Medicine Journal

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BackgroundIn the last few decades, the life expectancy of patients with transfusion‐dependent thalassaemia (TDT) and sickle cell disease (SCD) has improved significantly, in part because of improved iron chelation. Fertility challenges and pregnancy complications have historically limited reproductive options in this group; however, improved multi‐disciplinary care has made infertility a chronic disease complication requiring attention. Despite this, there are very few reports and no Australian data describing fertility and pregnancy outcomes in this population.AimsTo identify the rate of assisted reproductive technologies (ART) utilisation in our female transfusion‐dependent haemoglobinopathy patients and to establish the nature of maternal and neonatal complications in this cohort.MethodsA 20‐year retrospective analysis (1997–2017) at an Australian centre captured data on conception rates, use of assisted reproductive techniques (ART), and pregnancy and neonatal outcomes in female transfusion‐dependent haemoglobinopathy patients.ResultsConception was attempted in 14 women (11 TDT and three SCD) during the study period. A total of 28 pregnancies resulting in 25 live births were recorded. ART supported 13 conceptions. A positive association was not identified between elevated mean serum ferritin and ART use; however, all patients with an established diagnosis of hypogonadotropic hypogonadism (HH) required ART. Maternal complications included gestational diabetes mellitus and post‐partum haemorrhage. There were no cardiac complications. Two‐thirds of women underwent lower segment caesarean section, with prematurity complicating 20% of births. There were no neonatal or maternal deaths.ConclusionPregnancy is an achievable goal for women with transfusion‐dependent haemoglobinopathies, although the support of ART may be required in a subset of patients.

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Section: Discussionmentioning

confidence: 99%

Pregnancy and assisted reproductive technology use in Australian female transfusion‐dependent haemoglobinopathy patients: a 20‐year retrospective analysis

Anderson

Perram

Nelson

et al. 2023

Internal Medicine Journal

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“…One limitation to consider, however, is that this specific study targeted a small population without measuring the pregnancy rate [59].…”

Section: Thalassemia Affecting Oocyte Qualitymentioning

confidence: 99%

The Major Factors Affecting Oocyte Quality in IVF Cycles: A Narrative Review

Boueri,

Saliba,

Haydamous

et al. 2023

Int J Clin Res

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Background: The role of assisted reproductive technologies, including in-vitro fertilization [IVF], is increasing daily because of the significant rise in subfertility cases. Among women, the most observed causes of infertility are primary ovarian insufficiency and premature ovarian failure, accounting for 25% of cases, followed by tubal damage (20%) and uterine abnormalities (10%), all contributing to the increase in IVF cases among couples. The success of IVF depends on various factors; however, the role of oocyte quality and maturation level is considered a pivotal cardinal factor for the success rates of IVF. Methods: A thorough literature analysis was performed using the following search terms: “Oocyte Quality” and “IVF cycle.” The databases searched included PubMed, Google Scholar, MEDLINE, Cochrane Library, and ResearchGate. Discussion: IVF success rates especially depend on oocyte quality and level of maturation. Several factors affecting these two factors include obesity, which increases O2 and H2O2 levels resulting in elevated endoplasmic reticulum [ER] stress; Polycystic Ovary Syndrome [PCOS]; age; endometriosis; cyclic nucleotides used in IVF; thalassemia major which is associated with lower ovarian reserve and increased redox activity malignancies, and anti-neoplastic drugs, which may contribute to premature ovarian insufficiency. Various treatment options were proposed to improve oocyte quality and maturation level, including growth hormone [GH] supplementation alongside ovarian supplementation, autologous mitochondrial transfer, luteal phase ovarian stimulation, administration of MI-Melatonin-Vitamin D3, Duphaston, and putrescine supplementation. Conclusion: With the rising number of subfertility cases, the importance of Assisted Reproductive Technologies [ART] is growing. The success rate of IVF on oocyte quality and level of maturation level, and few with several factors affecting these. Though numerous treatment options have been proposed to enhance oocyte quality and maturation, not all have been deemed beneficial.

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“…Thalassemia is one of the most common genetic hemoglobinopathies that can result in severe anemia. 1 , 2 It is highly prevalent in Southeast Asia, the Indian subcontinent and Mediterranean and Middle Eastern countries, collectively known as the ‘World Thalassemia Belt’. In Bangladesh, 6 to 12% of the population are carriers of a gene causing thalassemia.…”

Section: Introductionmentioning

confidence: 99%