Oogenesis and ovarian development in the prenatal pig

Black, J. L.; Erickson, B. H.

doi:10.1002/ar.1091610105

Cited by 87 publications

(55 citation statements)

References 14 publications

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“…Deanesly (1975,1977) found that, in the horse, the first groups of oocytes degenerate and disappear and that, much later, peripheral oogonia develop into oocytes and eventually normal primordial follicles. Black & Erickson (1968) and Mauleon (1969) suggested a similar pattern in other eutherians. In the tammar there is no such disruption of germ cell development although some degeneration was noted early in each wave of successive stages.…”

Section: Discussionmentioning

confidence: 60%

“…Detailed descriptions of the early pattern of development of female germ cells have been published for several species of eutherian mammals, including the rat (Beaumont & Mandi, 1962), man (Baker, 1963), guinea-pig (Ioannou, 1964), rhesus monkey (Baker, 1966), pig (Black & Erickson, 1968), sheep (Mauléon, 1969(Mauléon, , 1975, horse (Deanesly, 1975(Deanesly, , 1977 and calf (Prépin, Jost & Vigier, 1977). By contrast, accounts of germ cell development in female marsupials are very restricted.…”

Section: Introductionmentioning

confidence: 99%

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Germ cell development in female pouch young of the tammar wallaby (Macropus eugenii)

Alcorn¹,

Robinson²

1983

Reproduction

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Germ cell development in female pouch young of the tammar wallaby (Macropus eugenii)

Alcorn¹,

Robinson²

1983

Reproduction

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“…How the FOXO3 level increases in prepubertal porcine ovaries is not well understood. Prepubertal porcine ovaries contain a large number of developing follicles (Black & Erickson 1965). Developing follicles are found in well-vascularized cortical-medullary borders, whereas primordial follicles are located in a relatively avascular region in the cortex (Gougeon 2004).…”

Section: Discussionmentioning

confidence: 99%

“…The ovaries of infant pigs contain a large number of primordial follicles and also a small population of developing follicles that contain growing oocytes. Primordial follicles represent more than 95% of the total follicular proportion in porcine ovaries at 2 weeks after birth (Black & Erickson 1965, Oxender et al 1979. The ovaries of prepubertal and adult animals possess numerous growing and fully grown oocytes in the developing and mature follicles respectively, as well as a number of nongrowing primordial oocytes as the future stock.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of FOXO3 induces primordial oocyte activation in pigs

Moniruzzaman¹,

Lee²,

Zengyo³

et al. 2010

Reproduction

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Mammalian ovaries are endowed with a large number of primordial follicles, each containing a nongrowing oocyte. Only a small population of primordial oocytes (oocytes in primordial follicles) is activated to enter the growth phase throughout a female's reproductive life. Little is known about the mechanism regulating the activation of primordial oocytes. Here, we found that the primordial oocytes from infant pigs (10-to 20-day-old) grew to full size at 2 months after xenografting to immunodeficient mice, whereas those from prepubertal pigs (6-month-old) survived without initiation of their growth even after 4 months; thereafter, they started to grow and reached full size after 6 months. These results suggest that the mechanism regulating the activation of primordial oocytes in prepubertal pigs is different from that in infant pigs. In this regard, the involvement of FOXO3, a forkhead transcription factor, was studied. In prepubertal pigs, FOXO3 was detected in almost all (94G2%) primordial oocyte nuclei, and in infant pigs, 42G7% primordial oocytes were FOXO3 positive. At 4 months after xenografting, the percentage of FOXO3-positive primordial oocytes from prepubertal pigs had decreased to the infant level. Further, siRNA was designed to knock down porcine FOXO3. FOXO3-knockdown primordial follicles from prepubertal pigs developed to the antral stage accompanied by oocyte growth at 2 months after xenografting. These results suggest that primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

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“…The oocytes of large animals are relatively large in size and have a long growth phase. For example, the period from initiation of the primordial follicle development to the final preovulatory stage takes several months in pigs [2]. Therefore, in vitro growth of oocytes in the primordial follicles of large animals is still challenging.…”

mentioning

confidence: 99%

KIT-KIT Ligand in the Growth of Porcine Oocytes in Primordial Follicles

Moniruzzaman

Miyano

2007

Journal of Reproduction and Development

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Abstract. Mammalian ovaries are endowed with a huge number of small oocytes in primordial follicles (primordial oocytes). The mechanism regulating initiation of oocyte growth and follicular development is not well understood. Several growth factors and cytokines are known to be involved in oocyte growth and follicular development. Herein, the involvement of KIT, a receptor tyrosine kinase, and its ligand, KIT ligand (KL), in the initiation of porcine oocyte growth was examined. At first, KIT expression was examined immunohistochemically in primordial oocytes from neonatal (10-20 days) and prepubertal (about 6 months) pigs. Similar expression of KIT was detected in all oocytes from both the neonatal and prepubertal pigs. Next, to examine the growth of primordial oocytes, ovarian tissues containing primordial oocytes were xenotransplanted into immunodeficient SCID mice. Primordial oocytes from the neonatal pigs grew with follicular development as described previously, whereas those from the prepubertal pigs did not initiate growth in the xenografts after 2 months. To stimulate the growth of primordial oocytes from the prepubertal pigs, they were cultured in a medium supplemented with KL (50 and 100 ng/ml) for 1 or 3 days before xenografting. After 2 months, however, the oocytes did not grow, and the primordial follicles did not develop, although a higher number of primordial oocytes survived in the KL-treated tissues. These results suggest that KIT-KL might not be associated with the growth initiation of porcine primordial oocytes, although they do enhance the survival of the oocytes.

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Oogenesis and ovarian development in the prenatal pig

Cited by 87 publications

References 14 publications

Germ cell development in female pouch young of the tammar wallaby (Macropus eugenii)

Germ cell development in female pouch young of the tammar wallaby (Macropus eugenii)

Knockdown of FOXO3 induces primordial oocyte activation in pigs

KIT-KIT Ligand in the Growth of Porcine Oocytes in Primordial Follicles

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