Op-014 Do Hypertension and Prehypertension Count as Cardiovascular Risk Factors Among Women in an Iranian Society?

Sadeghi, Mohammad Reza; Aghababaei, Esmaeil; Talaei, Mohammad; Sarrafzadegan, N.

doi:10.1016/s0167-5273(12)70008-6

Cited by 2 publications

(10 citation statements)

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“…Our final primary analysis included 19 articles [7-11,18-31], with a total of 468,561 participants, derived from 18 prospective cohort studies (two articles were from the Strong Heart Study and reported the risk factors for CHD [19] and stroke [24], respectively). Eighteen of the primary papers were published in full and one was in abstract form [10]. However, study data from this abstract were acquired by correspondence with the main author.…”

Section: Resultsmentioning

confidence: 99%

“…All prospective cohort studies were derived from the general population. Of the 18 studies 11 were from Asia (3 from China [7,25,29], 6 from Japan [18,23,26-28,31], and 2 from Iran [10,30]); 5 were from the United States [8,9,19-21,24]; and 1 each was from Turkey [22] and Germany [11]. The proportion of Asians was 79.6% (n = 372,927).…”

Section: Resultsmentioning

confidence: 99%

“…The follow-up duration ranged from 2.7 years [28] to 31 years [9]. Two studies enrolled women only [10,21], whereas all others enrolled both genders. All studies adjusted adequately for potential confounders (at least five of six factors: age, sex, DM, BMI or other measure of overweight/obesity, cholesterol and smoking) except for one study that adjusted for age, sex, heart rate, smoking and obesity [22].…”

Section: Resultsmentioning

confidence: 99%

“…In large populations, individuals with prehypertension are also more likely to have diabetes [5], impaired fasting glucose [4], metabolic syndrome [36], and dyslipidemia than normotensive individuals [4]. After controlling for these risk factors, some prospective studies have demonstrated prehypertension is still an independent risk factor for CVD [6-9], while others have not shown the same results [10,11]. In our meta-analysis, all of the included studies adequately adjusted for potential confounders (at least five of six factors: age, sex, DM, BMI or other measure of over-weight/obesity, cholesterol and smoking) except one study which adjusted for age, sex, heart rate, smoking and obesity [22].…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 90% of individuals with prehypertension have at least one other cardiovascular risk factor and 68% have at least one significant clinical risk factor for heart disease or stroke [5]. Some studies have demonstrated that prehypertension is an independent risk factor for cardiovascular disease (CVD) [6-9], while others have not shown the same results after data were adjusted for baseline cardiovascular risk factors [10,11]. It remains unclear whether mild BP elevation directly increases the risk of cardiovascular disease or whether other concurrent risk factors are responsible for the increase [12].…”

Section: Introductionmentioning

confidence: 99%

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Prehypertension and incidence of cardiovascular disease: a meta-analysis

Huang

Wang

Cai

et al. 2013

BMC Med

206

123

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BackgroundProspective cohort studies of prehypertension and the incidence of cardiovascular disease (CVD) are controversial after adjusting for other cardiovascular risk factors. This meta-analysis evaluated the association between prehypertension and CVD morbidity.MethodsDatabases (PubMed, EMBASE and the Cochrane Library) and conference proceedings were searched for prospective cohort studies with data on prehypertension and cardiovascular morbidity. Two independent reviewers assessed the reports and extracted data. The relative risks (RRs) of CVD, coronary heart disease (CHD) and stroke morbidity were calculated and reported with 95% confidence intervals (95% CIs). Subgroup analyses were conducted on blood pressure, age, gender, ethnicity, follow-up duration, number of participants and study quality.ResultsPooled data included the results from 468,561 participants from 18 prospective cohort studies. Prehypertension elevated the risks of CVD (RR = 1.55; 95% CI = 1.41 to 1.71); CHD (RR = 1.50; 95% CI = 1.30 to 1.74); and stroke (RR = 1.71; 95% CI = 1.55 to 1.89). In the subgroup analyses, even for low-range prehypertension, the risk of CVD was significantly higher than for optimal BP (RR = 1.46, 95% CI = 1.32 to 1.62), and further increased with high-range prehypertension (RR = 1.80, 95% CI = 1.41 to 2.31). The relative risk was significantly higher in the high-range prehypertensive populations than in the low-range populations (χ2= 5.69, P = 0.02). There were no significant differences among the other subgroup analyses (P>0.05).ConclusionsPrehypertension, even in the low range, elevates the risk of CVD after adjusting for multiple cardiovascular risk factors.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prehypertension and incidence of cardiovascular disease: a meta-analysis

Huang

Wang

Cai

et al. 2013

BMC Med

206

123

View full text Add to dashboard Cite

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Prehypertension and the Risk of Coronary Heart Disease in Asian and Western Populations: A Meta‐analysis

Huang

Cai

Liu

et al. 2015

JAHA

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BackgroundThe results of studies on the association between prehypertension (blood pressure 120 to 139/80 to 89 mm Hg) and coronary heart disease (CHD) remain controversial. Furthermore, it is unclear whether prehypertension affects the risk of CHD in Asian and Western populations differently. This meta‐analysis evaluated the risk of CHD associated with prehypertension and its different subgroups.Methods and ResultsThe PubMed and Embase databases were searched for prospective cohort studies with data on prehypertension and the risk of CHD. Studies were included if they reported multivariate‐adjusted relative risks (RRs) with 95% CIs of CHD from prehypertension. A total of 591 664 participants from 17 prospective cohort studies were included. Prehypertension increased the risk of CHD (RR 1.43, 95% CI 1.26 to 1.63, P<0.001) compared with optimal blood pressure (<120/80 mm Hg). The risk of CHD was higher in Western than in Asian participants (Western: RR 1.70, 95% CI 1.49 to 1.94; Asian: RR 1.25, 95% CI 1.12 to 1.38; ratio of RRs 1.36, 95% CI 1.15 to 1.61). The population‐attributable risk indicated that 8.4% of CHD in Asian participants was attributed to prehypertension, whereas this proportion was 24.1% in Western participants.ConclusionsPrehypertension, even at the low range, is associated with an increased risk of CHD. This risk is more pronounced in Western than in Asian populations. These results supported the heterogeneity of target‐organ damage caused by prehypertension and hypertension among different ethnicities and underscore the importance of prevention of CHD in Western patients with prehypertension.

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Op-014 Do Hypertension and Prehypertension Count as Cardiovascular Risk Factors Among Women in an Iranian Society?

Cited by 2 publications

References 0 publications

Prehypertension and incidence of cardiovascular disease: a meta-analysis

Prehypertension and incidence of cardiovascular disease: a meta-analysis

Prehypertension and the Risk of Coronary Heart Disease in Asian and Western Populations: A Meta‐analysis

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