OP-095 Association of Genetic Polymorphisms with Endothelial Dysfunction in Chronic Heart Failure

Köse, Murat; Akpınar, Timur Selçuk; Özkök, Abdullah; Açar, Göksel; Bakkaloğlu, Oğuz Kağan; Şumnu, Abdullah; Erk, Osman; Kayacan, M.S.; Oflaz, Hüseyin; Akkaya, Vakur; Demirel, Aslıhan

doi:10.1016/j.amjcard.2014.01.070

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was shown that endothelial dysfunction was present in chronic heart failure patients and that was partially predicted by ecNOS and AT1R genes' polymorphisms. Moreover, authors urged further investigations to better understand the molecular mechanisms and the clinical implications, particularly to assess whether patients with specific gene polymorphisms would benefit from a more aggressive medical and interventional management (Kose et al 2014). Individual differences in endothelial function and hence, susceptibility to atherosclerosis, might relate not only to different levels of exposure to risk factors but also to inter-individual differences in the carriage of risk alleles of genes expressed in the vascular endothelium.…”

Section: Discussionmentioning

confidence: 99%

The role of NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients

Sydorchuk¹,

Sydorchuk²,

Gutnitska³

et al. 2023

gpb

View full text Add to dashboard Cite

The mechanisms orchestrating the balance between nitric oxide and endothelium-derived contracting factors, and genetic predisposition to endothelial dysfunction in hypertensive patients remain to be determined. One-hundred hypertensive patients participated in the case-control study to clarify the risk of endothelial dysfunction and carotid "intima media" thickness (IMT) changes depending on NOS3 (rs2070744) and GNB3 (rs5443) genes' polymorphisms. It is found that presence of NOS3 gene's С-allele significantly elevates the risk of atherosclerotic plaques on carotid arteries (OR95%CI: 1.24-11.20; р = 0.019) and the probability of low NOS3 gene expression (OR95%CI: 17.72-520.0; р < 0.001). Homozygous carriage of С-allele of GNB3 gene is protective and corresponds to the lowest chances of the carotid IMT increase, atherosclerotic plaques formation and sVCAM-1 elevation (OR = 0.10-0.34; OR95%CI: 0.03-0.95; р ≤ 0.035-0.001). Vice versa, Т-allele of GNB3 gene significantly augments the risk of the carotid IMT increase (OR95%CI: 1.09-7.74; р = 0.027) including development of atherosclerotic plaques, associating GNB3 (rs5443) with cardiovascular pathology.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients

Sydorchuk¹,

Sydorchuk²,

Gutnitska³

et al. 2023

gpb

View full text Add to dashboard Cite

show abstract

“…In the study of Kose M. et al . 22 , endothelial dysfunction was present in congestive HF, and the presence of endothelial nitric oxide synthase promoter polymorphism (thymidine to cytosine transition [T(-786)C]) further impaired endothelium-dependent vasodilation. In addition to its well-recognized role in the regulation of vascular tone, nitric oxide modulates sympathetic and parasympathetic nervous system activities.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its well-recognized role in the regulation of vascular tone, nitric oxide modulates sympathetic and parasympathetic nervous system activities. Abnormalities of both autonomic control and nitric oxide synthase activity are known to occur in patients with congestive HF 22 . Recently, a polymorphism of the promoter of the endothelial nitric oxide synthase (eNOS) gene has been associated with a reduction of eNOS activity.…”

Section: Discussionmentioning

confidence: 99%

The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction

Bielecka‐Dąbrowa

Sakowicz

Pietrucha

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growth factor β (TGF β) rs1800471], endothelial function [-786 T/C nitric oxide synthase (NOS) rs2070744], glucose and lipid metabolism [Pro12Ala peroxisome proliferator activated receptor (PPAR)γ rs1801282], and vitamin D metabolism [cytochrome P450 27B1 (CYP27B1) C-1260A].110 patients with HF with preserved and mid-range ejection fraction (HFpEF and HFmrEF) were recruited. GG homozygotes in 174 G/C of IL6 polymorphism are characterized by higher values of estimated glomerular filtration rate based on the study Modification of Diet in Renal Disease (eGFR MDRD) and C allele in the NOS polymorphism and AA profile in C-1260A of CYP27B1 polymorphism correlated with a lower eGFR (MDRD). In multivariate analysis the CG genotype for 174 G/C of IL-6 and allele A in C-1260A of CYP27B1 are the only SNPs independently associated with worse course of HFpEF and HFmrEF. These data confirm the importance of the selected SNPs in aggravation and complications of hypertension.

show abstract

“…The recombinant of brain natriuretic peptide (rhBNP) was approved in 2001 by the US Food and Drug Administration (FDA) for the treatment of decompensates heart failure. The rhBNP could reduce cardiac stress, which were through vasodilatory properties, diuresis,and improvement inotropic arrhythmias [14].…”

Section: Discussionmentioning

confidence: 99%

Effects of rhBNP on Elderly Emergency Patients with Acute Heart Failure

Wang¹,

Y²,

Guo³

et al. 2018

Arch Med

View full text Add to dashboard Cite

Objective: To study the effect of re-combinant human brain natriuretic peptide (rhBNP) in older emergency patients with acute heart failure.Patients and Methods: A total of 130 patients were randomly divided into two groups as: rhBNP treatment group and sodium nitroprusside (SNP) treatment group, half by half. The rhBNP was taken once every three days for treatment. But dose was doubled at first time used. In the whole progress, it measured the concentration of rhBNP. Echocardiography examination and 6-minute walk testing (6MWT) were used to evaluate the improvement of heart function after rhBNP treatment, compared with SNP.Results: It taken vital symptoms assessment according to the clinical manifestations, once every four hours in the whole 48 hours emergency treatment procedure. Compared before and after treatment, there were significant improvement about LVEF (left ventricular ejection fraction), 6MWT and proBNP level changes in rhBNP group. Furthermore, it revealed that there were also significant differences in LVEF, 6MWT and proBNP level changes between rhBNP and SNP group. Conclusion:Recombinant human brain natriuretic peptide (rhBNP) could be used to treat old patients with acute heart failure in emergency with meaningful clinical value.

show abstract

OP-095 Association of Genetic Polymorphisms with Endothelial Dysfunction in Chronic Heart Failure

Cited by 4 publications

References 0 publications

The role of NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients

The role of NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients

The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction

Effects of rhBNP on Elderly Emergency Patients with Acute Heart Failure

Contact Info

Product

Resources

About