Op-135 Serum Pon1 and HDL Related Paf-Ah Enzyme Activities in Coronary Artery Disease Patients With High Circulating HDL Levels

Küçük, Hi̇lal Olgun; Kunak, Tolga; Küçük, Uğur; Ülgen, A.; Ünlü, Murat; Abacı, Adnan

doi:10.1016/s0167-5273(13)70136-0

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“…Experimental studies have shown that HDL inhibits the oxidative modification of LDL by detoxification of oxidized phospholipids produced during lipid peroxidation. This antioxidant effect is possible due to antioxidant properties of enzymes such as paraoxonase 1 (PON1) and/or platelet-activating factor acetylhydrolase (PAF-AH) [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Aronia melanocarpaTreatment and Antioxidant Status in Selected Tissues in Wistar Rats

Francik

Krośniak

Sanocka

et al. 2014

BioMed Research International

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Aronia juice is considered to be a source of compounds with high antioxidative potential. We conducted a study on the impact of compounds in the Aronia juice on oxidative stress in plasma and brain tissues. The influence of Aronia juice on oxidative stress parameters was tested with the use of a model with a high content of fructose and nonsaturated fats. Therefore, the activity of enzymatic (catalase, CAT, and paraoxonase, PON) and nonenzymatic (thiol groups, SH, and protein carbonyl groups, PCG) oxidative stress markers, which indicate changes in the carbohydrate and protein profiles, was marked in brain tissue homogenates. Adding Aronia caused statistically significant increase in the CAT activity in plasma in all tested diets, while the PON activity showed a statistically significant increase only in case of high fat diet. In animals fed with Aronia juice supplemented with carbohydrates or fat, statistically significant increase in the PON activity and the decrease in the CAT activity in brain tissue were observed. In case of the high fat diet, an increase in the number of SH groups and a decrease in the number of PCG groups in brain tissue were observed.

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Section: Resultsmentioning

confidence: 99%