[OP.1A.08] Prognostic Relevance of Resting Heart Rate in Obesity

Trevano, Fosca Quarti; Bombelli, Michele; Facchetti, Rita; Boggioni, I.; Nicoli, Francesco; Peronio, M.; Re, Alifanova; Mancia, Giuseppe

doi:10.1097/01.hjh.0000522982.93190.68

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“…A few prospective cohort studies have found that accelerated HR might predict the development of T2DM in different populations 9,10 . The rise of HR reflected the disorder of the autonomic nerve system, 11,12 which led to the excitation of sympathetic nerves, 13 which could result in obesity, decreased insulin sensitivity, inflammation, and the increasing risk of T2DM 14,15 . Nevertheless, although the aforementioned studies have shown that fast HR could be associated with the prevalence of T2DM, there was no clear risk threshold for HR to be a common accompaniment to T2DM.…”

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confidence: 99%

Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population‐based study

Zhu,

Chen,

Chen

et al. 2024

Journal of Diabetes

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BackgroundAlthough obesity and heart rate (HR) were closely related to the prevalence and development of type 2 diabetes mllitus (T2DM), few studies have shown a co‐association effect of them on T2DM. We aimed at assessing the interactive effects of HR and obesity with prevalence of T2DM in Chinese population, providing the exact cutpoint of the risk threshold for blood glucose with high HR.Materials and MethodsIn the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (REACTION) cohorts (N = 8398), the relationship between HR and T2DM was explored by linear regression, logistic regression, and restricted cubic spline, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Interaction terms between HR and body mass index (BMI) and HR and waist circumference (WC) were introduced into the logistic regression model.ResultsIn those with HR > 88.0 beats/min, fasting plasma glucose and oral glucose tolerance tests were significantly correlated with HR, and the prevalence of T2DM was highly correlated with HR (all p < .05). There were interactive associations of HR and obesity in patients with T2DM with HR < 74 beats/min.ConclusionHigh HR was in interaction with obesity, associating with prevalence of T2DM. The newly subdivided risk threshold for HR with T2DM might be HR > 88 beats/minute.image

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